Results 131 to 140 of about 15,451 (255)

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Petrelintide for Weight Management: Two Randomized, Controlled Phase 1 Trials

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Petrelintide is a long‐acting amylin analogue in development for weight management. The safety, tolerability, pharmacokinetics, and pharmacodynamics of petrelintide were evaluated in single ascending dose (SAD) and multiple ascending dose (MAD) trials. Materials and Methods Both trials were randomized, placebo‐controlled, and double‐blind.
Minna Brændholt Olsen, Jon Griffin, Ulrike Hövelmann, Stanislava Macura, Berith Fredsted Hagen, Dan Hesse, Tim Heise   +6 more
wiley   +1 more source

Phase IIB, Randomized, Double‐Blind, Placebo‐Controlled Clinical Trial of Intravenous Defibrotide for the Prevention and Treatment of Respiratory Distress and Cytokine Release Syndrome in COVID‐19

European Journal of Haematology, EarlyView.
ABSTRACT Introduction Endothelial dysfunction is key in COVID‐19 pathogenesis. This randomized, double‐blind phase IIb trial investigated continuous intravenous infusion of defibrotide in patients hospitalized with SARS‐CoV‐2 infection and respiratory failure.
Ruben Jara Rubio, Antonio José Martinez‐Mellado, Jonathan Kiwitt‐Cárdenas, José G. Clavel, Bartolomé García‐Perez, Pedro Castro, Maribel Diaz‐Ricart, Andrés Carrillo‐Alcaraz, Amparo López‐Bernús, Enrique Bernal Morell, Aychel Roura, Sonia Marín, Francisco‐José Ruiz‐López, Elena Solana‐Martinez, Domingo Martinez‐Baño, Carlos L. Albacete Moreno, Enriqueta Andreu Soler, Adrián Tellez Santoyo, Sara Fernández Méndez, Jose A. Noguera Velasco, Iria Cebreiros Lopez, Andrés Parrilla, Alberto Espuny‐Miró, David García‐Bernal, Miguel Blanquer, Andrés Sánchez‐Salinas, Francisca Iniesta, Cristina Hernandez Garcia, Manuel Muro, Alfredo Minguela Puras, Antonio Moreno‐Docón, Alberto M. Torres‐Cantero, Maria Munoz Garcia, Manuel Serrano, Massimo Iacobelli, Carmelo Carlo‐Stella, Lee‐Jen Wei, Paul G. Richardson, José M. Moraleda   +38 more
wiley   +1 more source

Exploring the microbiota–skin–brain axis: Chicory extract biotransformed into a postbiotic neurocosmetic enhancer of social and sensory experience

International Journal of Cosmetic Science, EarlyView.
Application of CHICORY EXTRACT by a consumer has the ability to evoke positive emotional responses in individuals who come into tactile contact with the treated skin. Abstract Objective Measuring the influence of cosmetic ingredients on the microbiota‐skin‐brain axis is a difficult challenge.
Stefan Hettwer, Emina Besic Gyenge, Loya Schoeffel, Brigit Suter, Barbara Obermayer   +4 more
wiley   +1 more source

Targeted keratin repair: A plant‐based approach to hair strength and surface restoration

International Journal of Cosmetic Science, EarlyView.
Application of Avena strigosa seed extract may reinforce keratin bonding, restoring hair fibre integrity by promoting intramolecular interactions at damaged sites of keratin proteins. Abstract Objective Chemical and thermal stress disrupts the intramolecular and intermolecular interactions that stabilize hair keratin, leading to structural degradation ...
Emina Besic Gyenge, Loya Schoeffel, Stefan Hettwer, Andreas Bosch, Cosimo Kropp, Brigit Suter, Barbara Obermayer   +6 more
wiley   +1 more source

An Evaluation of a New Ultrasonic Water Irrigator in the Management of Gingival Health: A Randomised Study

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Introduction This randomised, single‐blind, controlled study aimed to compare daily adjunctive use of an ultrasonic water irrigation device to dental floss in controlling plaque and gingival inflammation in patients with gingivitis. Methods Participants were randomly allocated to either daily use of an ultrasonic water irrigator or dental ...
Susan M. Bissett, Polina Gulakova, Katrin Unbereit, Robin A. Seymour, Philip M. Preshaw   +4 more
wiley   +1 more source

Computer Mapping of Water Quality in Saginaw Bay with LANDSAT Digital Data [PDF]

The author has identified the following significant results. LANDSAT digital data and ground truth measurements for Saginaw Bay (Lake Huron), Michigan, for 31 July 1975 were correlated by stepwise linear regression and the resulting equations used to ...
Mckeon, J. B., Rogers, R. H., Shah, N. J., Smith, V. E.   +3 more
core   +1 more source

Shedding light on the environmental efficiency of the public light service: minimising light pollution through the global Malmquist–Luenberger index

International Transactions in Operational Research, EarlyView.
Abstract The search for evidence in public management and the implementation of good management by public bodies is becoming increasingly important, and the principles of effectiveness and efficiency should be reinforced. Therefore, this paper aims to analyse the change in efficiency in the provision of public lighting services by local governments ...
Pablo Povedano‐Fernández, Gemma Pérez‐López, José Luis Zafra‐Gómez   +2 more
wiley   +1 more source

Frequency of islet autoantibody seropositivity among adults with newly diagnosed type 2 diabetes in the Kazakh population: A cross‐sectional study

Journal of Diabetes Investigation, EarlyView.
Among adults with newly diagnosed type 2 diabetes in Kazakhstan, 25.8% showed islet autoantibody positivity, indicating a substantial autoimmune component. ZnT8 and GADA were the most prevalent, supporting the importance of immunological assessment for accurate diabetes classification.
Khatimya Kudabayeva, Bibigul Tleumagambetova, Yerlan Bazargaliyev, Lorina Vudu   +3 more
wiley   +1 more source

Severity of pediatric pain in relation to school-related functioning and teacher support: an epidemiological study among school-aged children and adolescents [PDF]

, 2014
De Clercq, Bart, Goubert, Liesbet, Hublet, Anne, Logan, Deirdre E, Vervoort, Tine   +4 more
core   +1 more source

KOH 5% solution versus diclofenac 3% for the treatment of actinic keratosis – Results from a three‐armed RCT

Journal of the European Academy of Dermatology and Venereology, EarlyView.
In this RCT, KOH 5% demonstrated superior clinical success to diclofenac 3% and placebo at the end of treatment in patients with mild‐to‐moderate actinic keratosis and comparable long‐term efficacy to diclofenac. Its fast onset of efficacy and favourable tolerability make KOH a valuable treatment option in early‐stage actinic keratosis treatment ...
U. Reinhold, N. Leitz, R. Dominicus, E. L. Szabó, T. Dirschka, G. Popp, T. C. Fischer, N. Adamini, R. Ostendorf, M. Asefi, H. Durani, T. Hölting, U. Amann, F. Kreuziger, T. Assmann, H. Brüning, L. Freitag, K. Hoffmann, R. Gedschold   +18 more
wiley   +1 more source