Results 151 to 160 of about 7,195 (251)

Safety, Tolerability, Pharmacokinetics and Exploratory Pharmacodynamics of Melanin‐Concentrating Hormone Receptor‐1 Antagonist RGH‐706 in Healthy and Overweight or Obese Men

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim This Phase 1 program evaluated the safety, tolerability, pharmacokinetics and exploratory pharmacodynamics of the novel melanin‐concentrating hormone receptor‐1 antagonist RGH‐706. Methods Study A was a first‐in‐man, randomized trial comprising a double‐blind, placebo‐controlled single‐ascending‐dose part (0.1–162.5 mg) and a two‐way ...
Thomas Brevig   +10 more
wiley   +1 more source

Enhancement of Motor Skill Development in Dental Education Through an Art‐Based Course, Including the COVID‐19 Period

open access: yesEuropean Journal of Dental Education, EarlyView.
ABSTRACT Background Modern higher education requires a redefinition of pedagogical objectives to meet the evolving cognitive and perceptual demands of contemporary students. One such emerging objective is the cultivation of visual perceptions. Generational differences suggest that current students possess distinct cognitive profiles and learning ...
Adrienne Fazekas   +7 more
wiley   +1 more source

Conserved dimerization architecture in C‐type lectins from virus‐vector mosquitoes

open access: yesThe FEBS Journal, EarlyView.
C‐type lectins (CTLs) are involved in the detection of viral/microbial carbohydrates. We studied a family of soluble CTLs in the mosquito Aedes aegypti, which acts as a vector for viruses like dengue and Zika. Using crystallography, biophysics, and structure prediction approaches, we found that these proteins consistently pair together in the same ...
Mattia Bertinelli   +6 more
wiley   +1 more source

Targeted keratin repair: A plant‐based approach to hair strength and surface restoration

open access: yesInternational Journal of Cosmetic Science, EarlyView.
Application of Avena strigosa seed extract may reinforce keratin bonding, restoring hair fibre integrity by promoting intramolecular interactions at damaged sites of keratin proteins. Abstract Objective Chemical and thermal stress disrupts the intramolecular and intermolecular interactions that stabilize hair keratin, leading to structural degradation ...
Emina Besic Gyenge   +6 more
wiley   +1 more source

New insights from data analysis of 12 global clinical studies on hair shedding

open access: yesInternational Journal of Cosmetic Science, EarlyView.
Analysis of 12 clinical studies conducted across eight countries indicated that the majority of the hair loss (shedding) originates from the root and occurs throughout the hair care procedures (washing, drying and combing). In females, the ‘older’ group experienced more hair fall than the ‘younger’ group.
Yingjie Li   +9 more
wiley   +1 more source

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