Results 171 to 180 of about 15,451 (255)

Unveiling a New Link: Cholesterol Deficiency in Smith–Lemli–Opitz and Niemann–Pick C as a Driver of Ciliopathies

American Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1179-1191, June 2026.
ABSTRACT The ciliopathies are a group of genetic disorders caused by defective function of either the primary cilia (a large number) or the motile cilia (a much smaller number). These have been defined as diseases with mutations in genes encoding individual ciliary or cilia‐associated proteins.
Robert P. Erickson, Maria Teresa Fiorenza   +1 more
wiley   +1 more source

MAP4K1 and MAP4K2 regulate ABA-induced and Ca²⁺-mediated stomatal closure in <i>Arabidopsis</i>. [PDF]

Sci Adv
Yamashita K, Katagiri S, Takase H, Li Y, Oishi A, Otoguro A, Kamiyama Y, Yamauchi S, Wang YS, Takemiya A, Mori IC, Kollist H, Umezawa T.   +12 more
europepmc   +1 more source

A Novel Ultra‐Performance Liquid Chromatography‐Electrospray Ionisation‐Tandem Mass Spectrometry Method for Quantification of Imeglimin in Human Plasma: Application to a Bioequivalence Study

Analytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT The pharmaceutical market has recently witnessed the advent of a novel tetrahydrotriazene molecule belonging to the new pharmacological class “Glimins”, named Imeglimin (IMG). It has been approved in Japan as a safe and highly effective oral diabetic drug for type II diabetic patients.
Mina Wadie, Kamal A. Badr, Ahmed A. Hosny, Liliya Logoyda, Omnia M. El Sebai, Mamdouh R. Rezk   +5 more
wiley   +1 more source

Accuracy-Enhanced Calibration Method for Robot-Assisted Laser Scanning of Key Features on Large-Sized Components. [PDF]

Sensors (Basel)
Zhou Z, Zhang X, Sun X, Xia F, Zeng J.
europepmc   +1 more source

Multiple Primary Malignancies in Patients With Gastric Cancer: A Retrospective Study in National Cancer Center of China

Cancer Innovation, Volume 5, Issue 3, June 2026.
This study demonstrates multiple primary malignancies (MPMs) occur in 4.01% of gastric cancer patients and most commonly involve the esophagus, colorectum, and lung. Distinct differences are observed between synchronous and metachronous cases. These findings establish a clinical and epidemiological framework to inform future investigations into MPMs in
Guiling Zhu, Yutong Li, Bingzhi Wang, Liyan Xue, Yuchen Jiao, Xiaobing Wang, Chunxia Du   +6 more
wiley   +1 more source

Pain and Biopsychosocial Features in Patients With Myogenous Temporomandibular Disorders: A Retrospective Study According to the DC/TMD Axis II. [PDF]

Oral Dis
Ferrillo M, Marotta N, Demeco A, Gallelli L, Inzitari MT, Longo UG, Riccitiello F, Ammendolia A, Giudice A, de Sire A.   +9 more
europepmc   +1 more source

Targeting Cancer Cachexia: A Mechanistic Evaluation of Anti‐GDF‐15 Antibody‐Based Combination Therapies

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background In a recent Phase 2 trial in patients with cancer cachexia, the anti‐GDF‐15 antibody ponsegromab resulted in increased body weight, appetite, muscle mass and physical activity. This study provides compelling evidence that targeting the GDF‐15 pathway may offer a viable therapeutic strategy, while raising new mechanistic questions ...
Danna M. Breen, Stephanie Joaquim, Brianna LaCarubba Paulhus, Donald Bennett, Barbara Bernardo, Susie Collins, Ryan M. Esquejo, Ja Young Kim‐Muller, Laura Lin, Matthew Peloquin, Zhidan Wu, Shuxi Qiao, John C. Stansfield, Bei B. Zhang, Michelle I. Rossulek   +14 more
wiley   +1 more source

Clinical and cardiac magnetic resonance imaging features for differentiation between acute myocardial infarction with and without obstructive coronary arteries. [PDF]

Quant Imaging Med Surg
Shen LT, Yang ZG, Guo YK, Qian WL, Yan WF, Jiang YN, Shi K, Li Y.   +7 more
europepmc   +1 more source

Quantitative modelling of urban changes using multi-temporal Digital Elevation Models [PDF]

, 2014
De Maeyer, Philippe, De Wulf, Alain, Goossens, Rudi, Hendrickx, Marijn, Nuttens, Timothy, Stal, Cornelis, Tack, Frederik   +6 more
core   +2 more sources

From Concept to Clinic: Pre‐Clinical Testing and Regulatory Considerations in Spine Implant Development

JOR SPINE, Volume 9, Issue 2, June 2026.
Spine implant development follows a regulated, iterative pathway from clinical need and design through material selection, prototyping, preclinical validation, and regulatory approval to post‐market surveillance. Biomechanical evaluation and risk‐based frameworks integrate across all stages, ensuring safe, effective translation from concept to clinical
Amit Benady, Jerrin Thadathil Varghese, Ryan David Quarrington, Morsi Khashan, B. Gangadhara Prusty, Ashish Diwan   +5 more
wiley   +1 more source