Results 21 to 30 of about 1,011 (143)

Kaempferol Attenuates Spaceflight‐Associated Knee Cartilage Degradation by Targeting NOX4‐Mediated Mitochondrial Dysfunction

Advanced Science, EarlyView.
We have shown that both simulated and actual spaceflight contribute to cartilage degradation in the knees of mice. Using RNA sequencing and bioenergetic profiling, we identified NADPH oxidase 4 (NOX4) as a key factor driving these changes. Additionally, we found that kaempferol, a naturally occurring flavonoid that binds directly to NOX4, reduces ...
Yuesong Yin, Ruiling Xu, Meagan J. Makarczyk, Jia‐Jun Liu, Silvia Liu, Matthew Z. Shi, Roberta Di Carlo, Michael F. Almeida, Alex Garris, Sarah Day, Rebekah Sanchez‐Hodge, Jonathan C. Schisler, Aleeza H. Zilberman, Noah G. Allen, Angela J. Kubik, Elizabeth A. Blaber, Arnold Z. Olali, Wanqing Xie, Douglas C. Wallace, Christopher E. Mason, Peter G. Alexander, Giuseppe Intini, Afshin Beheshti, Hang Lin   +23 more
wiley   +1 more source

Solar Modulation of Galactic Cosmic Rays from Hydrogen to Nickel Based on a Modified Force-field Approach

The Astrophysical Journal
Galactic cosmic rays (GCRs), consisting predominantly of fully stripped nuclei, are significantly modulated by solar activity and represent a major radiation hazard for long-duration human space exploration.
Zhenning Shen, Caixia Li, Pingbing Zuo, Gang Qin, Xiaojun Xu   +4 more
doaj   +1 more source

Cosmic-Ray Transport in the Presence of a Fisk-type Heliospheric Magnetic Field: Investigating the Influence of Drift

The Astrophysical Journal
Drifts due to the gradients in, and curvatures of, the heliospheric magnetic field (HMF) play a significant role in the transport of galactic cosmic rays (GCRs) in the heliosphere.
J. S. Troskie, N. E. Engelbrecht, P. J. Steyn   +2 more
doaj   +1 more source

Relation between geomagnetic field and climate variability. Part 2: Probable mechanism

Геофизический журнал, 2015
In this study we show that correspondence of the main structures of geomagnetic field, near surface air temperature and surface pressure in the mid-latitudes, reported previously in the 1st part of the paper, has its physical foundation.
N. Kilifarska, V. Bakhmutov, G. Melnik
doaj   +1 more source

Time Dependence of 50–250 MeV Galactic Cosmic-Ray Protons between Solar Cycles 24 and 25, Measured by the High-energy Particle Detector on board the CSES-01 Satellite

The Astrophysical Journal Letters, 2023
Time-dependent energy spectra of galactic cosmic rays (GCRs) carry crucial information regarding their origin and propagation throughout the interstellar environment.
M. Martucci, R. Ammendola, D. Badoni, S. Bartocci, R. Battiston, S. Beolè, W. J. Burger, D. Campana, G. Castellini, P. Cipollone, S. Coli, L. Conti, A. Contin, M. Cristoforetti, G. D’Angelo, C. De Donato, C. De Santis, A. Di Luca, F. M. Follega, G. Gebbia, R. Iuppa, A. Lega, M. Lolli, N. Marcelli, G. Masciantonio, M. Mergè, M. Mese, C. Neubüser, F. Nozzoli, A. Oliva, G. Osteria, L. Pacini, F. Palma, F. Palmonari, B. Panico, A. Parmentier, S. Perciballi, F. Perfetto, P. Picozza, M. Pozzato, G. M. Rebustini, E. Ricci, M. Ricci, S. B. Ricciarini, U. Savino, Z. Sahnoun, V. Scotti, A. Sotgiu, R. Sparvoli, P. Ubertini, V. Vilona, V. Vitale, S. Zoffoli, P. Zuccon, O. P. M. Aslam, M. D. Ngobeni, M. S. Potgieter   +56 more
doaj   +1 more source

Responses of Soil Arthropod Communities to Varying Shading Levels in Agriphotovoltaic Systems

Integrative Zoology, EarlyView.
Soil fauna was primarily influenced by crop type and season rather than AgriPhotovoltaic (APV) panels. Elevated panels increased soil temperature and soil organic matter in early wheat stages, while shading enhanced soil moisture for tomatoes, benefiting moisture‐sensitive taxa.
Cristina Menta, Aldo Dal Prà, Jasmine Scartozzi, Federico Gavinelli, Giuseppe Concheri, Piergiorgio Stevanato, Gabriele Testa, Giancarlo Ghidesi, Sara Remelli   +8 more
wiley   +1 more source

Particle Transport from First Principles in the Early Heliosphere: κ1 Ceti as a Case Study for the Young Sun

The Astrophysical Journal
Several studies of Galactic cosmic-ray (GCR) modulation within the astrospheres of stars deemed to be proxies for the young Sun have concluded that the intensities of these particles would, at early stages of the Sun’s evolution, be negligible at 1 au ...
N. Eugene Engelbrecht, Konstantin Herbst, Klaus Scherer, Sean Oughton, Vladimir S. Airapetian   +4 more
doaj   +1 more source

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

British Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source

Raman analysis of organic refractory materials after energetic processing: Evidence for amorphous carbon on TNOs and comets

Meteoritics &Planetary Science, EarlyView.
Abstract Amorphous carbon (αC) is found in various extraterrestrial particles, including those thought to originate from the outer Solar System. αC can form through two main processes involving C‐rich materials: exposure to energetic charged particles and thermal processing.
M. Germanà, A. Vyjidak, G. A. Baratta, B. M. Giuliano, R. G. Urso, C. Scirè, D. Fulvio, T. Grassi, P. Jusko, P. Caselli, M. E. Palumbo   +10 more
wiley   +1 more source

On stellar activity cycle-related cosmic ray modulation effects in the astrosphere of Proxima Centauri

Journal of Space Weather and Space Climate
In the heliosphere, solar cycle-related changes in galactic cosmic ray (GCR) intensities have long been known to arise as a direct consequence of solar cyclic changes in, for example, the heliospheric magnetic field and the solar tilt angle.
Engelbrecht Nicholas Eugene, Herbst Konstantin   +1 more
doaj   +1 more source