Results 61 to 70 of about 633,557 (183)

Kaempferol Attenuates Spaceflight‐Associated Knee Cartilage Degradation by Targeting NOX4‐Mediated Mitochondrial Dysfunction

Advanced Science, Volume 13, Issue 48, 28 August 2026.
We have shown that both simulated and actual spaceflight contribute to cartilage degradation in the knees of mice. Using RNA sequencing and bioenergetic profiling, we identified NADPH oxidase 4 (NOX4) as a key factor driving these changes. Additionally, we found that kaempferol, a naturally occurring flavonoid that binds directly to NOX4, reduces ...
Yuesong Yin, Ruiling Xu, Meagan J. Makarczyk, Jia‐Jun Liu, Silvia Liu, Matthew Z. Shi, Roberta Di Carlo, Michael F. Almeida, Alex Garris, Sarah Day, Rebekah Sanchez‐Hodge, Jonathan C. Schisler, Aleeza H. Zilberman, Noah G. Allen, Angela J. Kubik, Elizabeth A. Blaber, Arnold Z. Olali, Wanqing Xie, Douglas C. Wallace, Christopher E. Mason, Peter G. Alexander, Giuseppe Intini, Afshin Beheshti, Hang Lin   +23 more
wiley   +1 more source

Value of Global Catastrophic Risk (GCR) Information: Cost-Effectiveness-Based Approach for GCR Reduction

, 2017
In this paper, we develop and illustrate a framework for determining the potential value of global catastrophic risk (GCR) research in reducing uncertainties in the assessment of GCR levels and the effectiveness of risk-reduction options.
Anthony Michael Barrett
core   +1 more source

Structure–Property Relationship of Supported Organochromium Catalysts Using Combined Computational XANES Analysis and Mechanistic Simulation

ChemCatChem, Volume 18, Issue 15, 14 August 2026.
Combined computational XANES analysis and mechanistic simulations reveal how lithiation of oxide supports tunes the structure and selectivity of single‐site organochromium catalysts, providing molecular‐level insights and a generalizable strategy for designing selective ethylene oligomerization catalysts.
Yu Lim Kim, Jacklyn N. Hall, Jiayi Xu, David M. Kaphan, Massimiliano Delferro, Arthur Jeremy Kropf, Cong Liu   +6 more
wiley   +1 more source

Simulation of subsurface particle radiation and leakage flux on the moon from solar energetic particles and galactic cosmic rays

European Physical Journal C: Particles and Fields
The moon is continuously bombarded by cosmic rays, primarily Galactic Cosmic Rays (GCR) and Solar Cosmic Rays, which generate complex secondary radiation in the lunar subsurface.
Zhengbao Wei, Yongbo Huang, Yaping Cheng
doaj   +1 more source

Genomic and Epidemiological Characterization of DENV‐1 and DENV‐2 Co‐Circulation During the 2023–2024 Dengue Epidemic in Espírito Santo, Brazil

Journal of Medical Virology, Volume 98, Issue 8, August 2026.
ABSTRACT In 2023 and 2024, Espírito Santo state, Brazil, experienced its largest dengue epidemic in 30 years, with record numbers of cases and deaths. This study aimed to characterize confirmed dengue cases and the dengue virus (DENV) during the epidemic and pre‐epidemic periods.
Nicolli Ribeiro de Jesus, Caio Santos de Souza, Mariene R. Amorim, João Paulo Cola, Raquel Gomes Catozo, Bruno Luiz M. Guedes, Bruna Caetano Pimenta, Julia Sthefany Nunes Zordan, Yasmim Barcellos Madeira Rosa, Henrique Tamanini Silva Moschen, Aline Souza Areias, Tatiane Comerio, Isabela Valim Sarmento, Julia Miranda Fardin, Daniel Claudio de Oliviera Gomes, Kiven Kumar, Eng Eong Ooi, Camila Malta Romano, Creuza Rachel Vicente   +18 more
wiley   +1 more source

The Constraint of Crewed Mars Missions Based on Current Radiation Dose Measurements

Space Weather
Crewed missions to Mars will be a milestone of future space exploration programs. However, the absence of Earth's magnetic field leaves astronauts directly exposed to unattenuated energetic particles in deep space, primarily galactic cosmic rays (GCRs ...
Chao Zhang, Weihao Liu, Jingnan Guo, Mikhail Dobynde, Robert F. Wimmer‐Schweingruber   +4 more
doaj   +1 more source

Endocrine modulation of glucocorticoid resistance in chronic asthma: A scoping review of the roles of thyroid hormone and adrenal axis pharmacology

Pakistan Journal of Pharmaceutical Sciences
Background: Chronic asthma affects 5%~10% of adults worldwide. Glucocorticoids (GCs) serve as first-line treatment, yet glucocorticoid resistance (GCR) in severe asthma complicates clinical management.
Haining Ning, Ruimin Qin, Xiaojun Cai
doaj   +1 more source

Diffusion Coefficients, Short-Term Cosmic Ray Modulation, and Convected Magnetic Structures

Advances in Astronomy, 2013
Three cases of large-amplitude, small spatial-scale interplanetary particle gradients observed by the anticoincidence shield (ACS) aboard the INTEGRAL spacecraft in 2006 are investigated.
John J. Quenby, Tamitha Mulligan, J. Bernard Blake, Diana N. A. Shaul   +3 more
doaj   +1 more source

Near‐Earth Cosmic Ray Modulation Index ϕ and Neutron Monitor Cutoff Rigidities at Hourly Cadence: Toward an Improved Monitoring of Solar‐Terrestrial Radiation Environment, Space Weather, and Space Climate

Journal of Geophysical Research: Space Physics, Volume 131, Issue 8, August 2026.
Abstract Cosmic rays (CRs) are energetic particles originating from galactic and extragalactic sources. When arriving into the solar system and the Sun's heliosphere, they are diverted and modulated by the magnetic activity of the Sun. This modulation can be quantified by the modulation parameter ϕ $\phi $ determined with the Force‐field approximation (
Pauli Väisänen, Nicholas Larsen, Sergey Koldobskiy, Markus Similä, David Pelosi, Miguel Orcinha   +5 more
wiley   +1 more source

Simulating Cosmic-Ray Diffusion Coefficients in the Presence of Synthetic Magnetic Turbulence with a Scalable Compressive Component: First Results for Heliosheath Parameters

The Astrophysical Journal Supplement Series
Galactic cosmic-ray (GCR) modulation studies have suggested that the ratio between the parallel and perpendicular mean free paths (MFPs) of these particles is a key parameter governing the observed, steep increase in high-energy GCR intensities within ...
J. S. Troskie, N. E. Engelbrecht
doaj   +1 more source