Results 81 to 90 of about 861,769 (363)
Advanced Science, EarlyView.Targeting USP1 is identified as a strategy that significantly enhances type I IFN‐dependent innate immune response within the TME following radiotherapy. Mechanistically, USP1 inhibition facilitates STING trafficking from ER to Golgi by preserving K27‐linked oligo‐ubiquitination of SAR1A, thereby facilitating efficient activation of the dsDNA‐cGAS ...
Weilin Zhou +15 more
wiley +1 more source
Archiv der Pharmazie, Volume 356, Issue 1, January 2023., 2023 Based on a simplified version of the morphinan scaffold, 3‐[3‐(phenalkylamino)cyclohexyl]phenol analogues were designed, synthesized and evaluated for their µ‐opioid receptor (MOR) antagonist activity in vitro and in silico. Docking studies indicate a peculiar combination of C‐1 stereochemistry and N‐substitutions as feasibly essential for MOR‐ligand ...
Graziella Tocco +8 more
wiley +1 more source
CBO\u27s 2011 Long-Term Projections for Social Security: Infographic [PDF]
, 2011 [Excerpt] By 2035, the growing number of beneficiaries due to the aging of the baby-boom generation will cause scheduled spending to climb to 6.1 percent of GDP, CBO estimates. However, there is uncertainty inherent in CBO\u27s projections; in 10 percent
Congressional Budget Office
core +1 more source
Acta Polytechnica, 2011 This paper presents an analysis of GDP and finds chaos in GDP. I tried to find a nonlinear lower-dimensional discrete dynamic macroeconomic model that would characterize GDP. This model is represented by a set of differential equations. I have used the Mathematica and MS Excel programs for the analysis.
openaire +4 more sources
THE ECONOMIC POTENTIAL OF SMALL AND MEDIUM BUSINESSES IN KAZAKHSTAN
Хабаршысы. Экономика сериясы, 2019 This article presents an economic analysis of the potential of small and medium-sized businesses in Kazakhstan. The purpose of the study is to study the dynamics of development of small and medium-sized businesses, and to assess its real role in the ...
Turarov D.R., Olzhash Y.A.
doaj
Mitigation and adaptation to Climate Change in Hungary [PDF]
Journal of Central European Agriculture, 2012 This review paper is a brief summary of the climate change story, transforming of primary concept from a scientific idea to a threatened world, and the contribution of Hungary in solution of above mentioned problems.
Márta HUNKÁR Zemankovics
doaj +1 more source
Advanced Science, EarlyView.Arf1 defects activate the AKT‐mTORC1‐SREBP1‐FASN pathway to increase lipid synthesis and disrupt ER‐mitochondrial‐lysosomal homeostasis in neurons. Impaired mitochondria secrete damaged mtDNA via mitochondria‐derived extracellular vesicles, which is phagocytosed by the microglia and activated inflammation signaling.
Xu Li +10 more
wiley +1 more source
The energy representation of world GDP [PDF]
arXiv, 2020 The dependence of world GDP on current energy consumption and total energy produced over the previous period and materialized in the form of production infrastructure is studied. The dependence describes empirical data with high accuracy over the entire observation interval 1965-2018.
arxiv
The Biderectional Relationship Between Human Development Index and Economic Growth in Romania [PDF]
Ovidius University Annals: Economic Sciences Series, 2019 Human development aims at expanding freedoms so that all human beings can live according to the choices they value. These freedoms have two fundamental aspects: freedom of well-being, represented by functionalities and abilities and freedom of mandate ...
Adina Trandafir
doaj
MTCH2 Suppresses Thermogenesis by Regulating Autophagy in Adipose Tissue
Advanced Science, EarlyView.This study demonstrates that MTCH2 acts as an evolutionarily conserved regulator of energy homeostasis across Drosophila, rodents, and humans. Adipose‐specific MTCH2 ablation enhances brown/beige adipose thermogenesis through Bcl‐2‐dependent autophagy, promoting energy expenditure and counteracting obesity‐associated metabolic disorders. These findings
Xin‐Yuan Zhao +17 more
wiley +1 more source