Results 111 to 120 of about 864,514 (341)

Analysis of cellular responses of macrophages to zinc ions and zinc oxide nanoparticles: a combined targeted and proteomic approach [PDF]

open access: yes, 2014
Two different zinc oxide nanoparticles, as well as zinc ions, are used to study the cellular responses of the RAW 264 macrophage cell line. A proteomic screen is used to provide a wide view of the molecular effects of zinc, and the most prominent results
Armand, Lucie   +13 more
core   +4 more sources

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Cellular and Secretory Proteins of the Salivary Glands of \u3cem\u3eSciara coprophila\u3c/em\u3e During the Larval-pupal Transformation [PDF]

open access: yes, 1972
The cellular and secretory proteins of the salivary gland of Sciara coprophila during the stages of the larval-pupal transformation were examined by electrophoresis in 0.6 mm sheets of polyacrylamide gel with both SDS-continuous and discontinuous buffer ...
Been, Anita Cavagnaro, Rasch, Ellen M.
core   +1 more source

Variably Protease‐Sensitive Prionopathy: Two New Cases With Motor Neuron‐Dementia Syndrome

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We describe two patients with variably protease‐sensitive prionopathy (VPSPr) who developed progressive upper motor neuron symptoms, insomnia, behavioral and cognitive decline, compatible with primary lateral sclerosis associated with frontotemporal dementia (FTD).
María Elena Erro   +10 more
wiley   +1 more source

Starch-Gel Electrophoresis of Peanut Protein

open access: yesEiyo To Shokuryo, 1971
落花生蛋白質をトリスークェン酸緩衝溶液 (pH8.60) で抽出し, トリス-クエン酸及びホウ酸-水酸化ナトリウム (pH8.60) の不連続緩衝液系を用いて澱粉ゲル電気泳動を行ない次の結果を得た。(1) 尿素及びメルカプトエタノールを含まない澱粉ゲルでは幅の広い2個のバンドと不明瞭な2個のバンドが得られたが, 尿素濃度の増加と共にバンドの数は増加しかつシャープになった。特に5M尿素及び0.02Mメルカプトエタノールを含むゲルを用いると10数個のバンドが検出された。(2) 5M尿素及び0.02Mメルカプトエタノールを含むゲルを用いて34品種の落花生について電気泳動を行なったところ, 同一系統に属する品種の泳動パターンはそれぞれ同じであったが, バージニアと ...
Yoshio Yoshino   +4 more
openaire   +2 more sources

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

open access: yesAdvanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley   +12 more
wiley   +1 more source

Development of methods for capillary isoelectric focusing of dairy proteins : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Chemistry at Massey University [PDF]

open access: yes, 2006
Capillary Isoelectric Focusing (CIEF) is a high-resolution technique which can be applied to the separation and characterisation of complex biological mixtures such as dairy proteins.
Gapper, Leyton William
core  

FeDSNP‐Pa Nanoassemblies: A Triple‐Action Therapeutic Strategy Targeting Oxidative Stress, Inflammation, and Pyroptosis for Retinal Ganglion Cell Protection in Glaucoma

open access: yesAdvanced Functional Materials, EarlyView.
FeDSNP‐Pa, a metallized nanoparticle loaded with sodium pyruvate (Pa), exerts triple therapeutic effects by scavenging reactive oxygen species (ROS), suppressing inflammatory responses, and inhibiting pyroptosis signaling pathways. This multifunctional neuroprotective strategy protecting retinal ganglion cells (RGCs) from elevated intraocular pressure ...
Yukun Wu   +5 more
wiley   +1 more source

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