Results 21 to 30 of about 1,556 (197)

A clinical evaluation of gelastic and dacrystic seizures: a multicenter study

Arquivos de Neuro-Psiquiatria, 2022
Background Gelastic seizures are extremely rare, short-lasting, unprovoked, and uncontrollable laughing attacks. We conducted this retrospective evaluation to determine whether these symptoms, manifesting in different forms, such as cheerful laughter ...
Aylin Bican Demir, Başak Yılmaz Öz, Mustafa Onur Yıldız, Bengi Gül Türk, Taner Tanrıverdi, Ahmet Bekar, Naz Yeni, İbrahim Bora   +7 more
doaj   +1 more source

Epilepsy: Molecular Pathogenesis and Emerging Therapies. [PDF]

MedComm (2020)
Progress has been made in the molecular pathogenesis of epilepsy, revealing multiple therapeutic targets. Recent advances in pharmacology, materials science, and surgical technique, coupled with progress in targeted therapy and disruptive epilepsy network technology, have led to the emergence of innovative strategies for epilepsy treatment.
Huang W, Zong J, Zhang Y, Li M, Pan S, Xiao Z.   +5 more
europepmc   +2 more sources

Optimized Stereo-Electroencephalography-Guided Three-Dimensional Radiofrequency Thermocoagulation for Hypothalamic Hamartomas-Related Epilepsy: A Single-Center Experience in 69 Patients. [PDF]

CNS Neurosci Ther
This study presents the largest cohort to date of SEEG‐3D RFTC treatment for HH‐related epilepsy, demonstrating it as a safe and effective option. Among 69 patients, 69.57% achieved overall seizure freedom, with GS‐free and nGS‐free rates of 80.65% and 75.93%, respectively (mean follow‐up: 41.0 ± 18.2 months).
Dai Y, Wang Y, Li Z, Fan X, Ren L, Sander JW, Wei P, Shan Y, Zhao G.   +8 more
europepmc   +2 more sources

Semiology in spontaneous versus cortical stimulation-induced seizures during SEEG: A within-patient comparison study. [PDF]

Epilepsia Open
Abstract Objective We aimed to study the concordance of seizure semiology in direct electrical stimulation‐induced seizures (SIS) compared to spontaneous seizures during stereoelectroencephalography (SEEG) and to report on patient‐level variables associated with habitual and atypical SIS.
Mahizhnan M, Dufau S, Phamnguyen J, Kahrom A, Craig D, McGonigal A.   +5 more
europepmc   +2 more sources

Cryptogenic Gelastic Epilepsy: A Pediatric Case Vignette [PDF]

Journal of Clinical and Diagnostic Research, 2014
Gelastic seizures, characterized by epileptic laughter, are rare and the majority is associated with hypothalamic hamartomas. We report a case with cryptogenic Gelastic seizure (without hypothalamic hamartoma), as the MRI was normal and, EEG and ...
Devendra Mishra, Monica Juneja, Taruna Chutani, Debashish Chowdhury   +3 more
doaj   +1 more source

Developmental and epileptic encephalopathy in patients with epilepsy due to hypothalamic hamartomas. [PDF]

Epilepsia
Abstract Objective What factors influence cognition and behavior in patients with epilepsy caused by hypothalamic hamartoma (HH)? Methods We conducted a retrospective study of 103 patients referred to the Epilepsy Center in Freiburg, Germany, over the past 24 years.
Wagner K, Demerath T, Metzger S, Niedermoser F, Metternich B, Putzar L, Urbach H, San Antonio-Arce V, Klotz KA, Schulze-Bonhage A.   +9 more
europepmc   +2 more sources

A Case of Gelastic Epilepsy Associated with Tuberosclerosis: Where is the Lesion Corresponding to Electroencephalography?

Archives of Epilepsy, 2020
Summary Gelastic seizures are typically associated with hypothalamic hamartoma. Given the rarity of gelastic seizures, pathways for the motor and emotional aspects of laughter have been hypothesized but remain unclear.
Nur Türkmen, Bülent Oğuz Genç
doaj   +1 more source

Optogenetically-induced sustained hypothalamic hyperexcitability impairs memory via thalamic spread. [PDF]

Epilepsia
Abstract Objective Clinical investigators have hypothesized that interictal epileptiform discharges (IEDs) generated by hypothalamic hamartoma (HH) lead to cognitive dysfunction in patients with drug‐resistant gelastic seizures. Herein we provide causal evidence supporting this hypothesis by demonstrating that excitatory neural bursts, when propagating
Sonoda M, Aimi H, Kawasaki K, Toda H, Hirai S, Horie M, Meguro R, Asano E, Okado H, Kameyama S, Yamamoto T, Hasegawa I.   +11 more
europepmc   +2 more sources

Interictal Spike EEG Source Analysis in Hypothalamic Hamartoma Epilepsy [PDF]

, 2002
Objective: The epilepsy associated with the hypothalamic hamartomas constitutes a syndrome with peculiar seizures, usually refractory to medical therapy, mild cognitive delay, behavioural problems and multifocal spike activity in the scalp ...
Calado, E, Cunha, JP, Leal, A, Passão, V, Vieira, JP   +4 more
core   +3 more sources

Clinical and anatomical characteristics of basal temporal seizures: A systematic review. [PDF]

Epileptic Disord
Abstract This review aimed to characterize the clinical semiology and anatomical correlates of seizures originating in the basal temporal region, an underrecognized epilepsy subtype, and to identify features that distinguish it from other forms of temporal lobe epilepsies (TLE).
Bartolomei F, Pizzo F, Lagarde S.
europepmc   +2 more sources