Results 131 to 140 of about 3,125,328 (279)

Interleukin-6-derived cancer-associated fibroblasts activate STAT3 pathway contributing to gemcitabine resistance in cholangiocarcinoma

, 2022
Yingpinyapat Kittirat, Manida Suksawat, Suyanee Thongchot, Sureerat Padthaisong, Jutarop Phetcharaburanin, Arporn Wangwiwatsin, Poramate Klanrit, Sakkarn Sangkhamanon, Attapol Titapun, Watcharin Loilome, Hideyuki Saya, Nisana Namwat   +11 more
openalex   +1 more source

NLRP3 augmented resistance to gemcitabine in triple-negative breast cancer cells via EMT/IL-1β/Wnt/β-catenin signaling pathway [PDF]

, 2020
Qiao Zheng, Dejiao Yao, Yi Cai, Tiecheng Zhou   +3 more
openalex   +1 more source

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, EarlyView.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source

Targeting Genome Maintenance Defects of Cancers Using Chain‐Terminating Nucleoside Analogs

Cancer Science, EarlyView.
Nucleoside analogs interfere with DNA replication either by their chain‐terminating properties or by serving as DNA damage on the template. The genome maintenance pathways required to maintain cellular tolerance to each nucleoside analog vary depending on the drug.
Ryotaro Kawasumi, Rubaiat E. Tabassum, Kouji Hirota   +2 more
wiley   +1 more source

Figure S2 from Deoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance [PDF]

, 2023
Simona Dalin, Mark R. Sullivan, Allison N. Lau, Beatrice Grauman-Boss, Helen S. Mueller, Emanuel Kreidl, Silvia Fenoglio, Alba Luengo, Jacqueline A. Lees, Matthew G. Vander Heiden, Douglas A. Lauffenburger, Michael T. Hemann   +11 more
openalex   +1 more source

Targeting SPP1‐CD44‐Hedgehog Axis Elicits Therapeutic Effects in Hepatocellular Carcinoma by Suppressing Intratumoral Fibrosis

Cancer Science, EarlyView.
SPP1 was identified as a key driver of intratumoral fibrosis and hepatocellular carcinoma (HCC) progression through transcriptomic, histological, and functional analyses. Mechanistically, SPP1 promotes HSC activation and fibrosis via the SPP1–CD44–GLI1 axis, and pharmacologic inhibition of Hedgehog signaling effectively reduces tumor growth and ...
Atsushi Nara, Shu Shimada, Yoshimitsu Akiyama, Megumi Hatano, Yusuke Chino, Suguru Miyazawa, Hanako Tamura, Daisuke Asano, Yoshiya Ishikawa, Hiroki Ueda, Shuichi Watanabe, Eriko Katsuta, Keiichi Akahoshi, Kenichi Ohashi, Minoru Tanabe, Daisuke Ban, Shinji Tanaka   +16 more
wiley   +1 more source

RGDV-modified gemcitabine: a nano-medicine capable of prolonging half-life, overcoming resistance and eliminating bone marrow toxicity of gemcitabine

International Journal of Nanomedicine, 2019
Wenchao Liu1,2, Yujia Mao1,2, Xiaoyi Zhang1,2, Yaonan Wang1,2, Jianhui Wu1,2, Shurui Zhao1,2, Shiqi Peng1,2, Ming Zhao1–3 1Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Department of Medicinal Chemistry, School of ...
Liu W, Mao Y, Zhang X, Wang Y, Wu J, Zhao S, Peng S, Zhao M   +7 more
doaj  

Targeting the sphingolipid metabolism to defeat pancreatic cancer cell resistance to the chemotherapeutic gemcitabine drug [PDF]

, 2009
Julie Guillermet‐Guibert, Lise Davenne, Dmitri Pchejetski, Nathalie Saint‐Laurent, Leyre Brizuela, Céline Guilbeau‐Frugier, Marie‐Bernadette Delisle, Olivier Cuvillier, Christiane Susini, Corinne Bousquet   +9 more
openalex   +1 more source

Hippo Pathway Drives Durable Non‐Cell‐Autonomous Ferroptosis Resistance in Lung Cancer

Cancer Science, EarlyView.
YAP/TAZ, key effectors in lung cancer progression, paradoxically sensitize tumor cells to ferroptosis. This study reveals that YAP/TAZ‐low cells confer non‐cell‐autonomous, GCH1‐mediated durable ferroptosis resistance to neighboring YAP/TAZ‐high cells via a soluble factor, highlighting a Hippo pathway‐linked mechanism of tumor adaptation and survival ...
Mohamed Fathi Saleh, Akihiro Nita, Yudai Ohta, Aya Kobayashi, Hao Li, Yasuhisa Sakamoto, Toshiro Moroishi   +6 more
wiley   +1 more source

Combined Blockade of Src Kinase and Epidermal Growth Factor Receptor with Gemcitabine Overcomes STAT3-Mediated Resistance of Inhibition of Pancreatic Tumor Growth [PDF]

, 2011
Nagathihalli S. Nagaraj, M. Kay Washington, Nipun B. Merchant   +2 more
openalex   +1 more source