Results 141 to 150 of about 3,125,328 (279)

SUSD2 Promotes Metastasis and Primary Tumor Growth in Pancreatic Cancer Cells via Integrin–FAK Signaling Activation

Cancer Science, EarlyView.
This study investigates the role of Sushi domain‐containing 2 (SUSD2) in pancreatic ductal adenocarcinoma (PDAC) and demonstrates that SUSD2 enhances both metastasis and primary tumor growth by promoting integrin β1–FAK signaling. SUSD2 interacts with integrin β1, enhancing adhesion to extracellular matrix (ECM) components such as collagen 1 and ...
Junjiro Yoshida, Tomokazu Ohishi, Isao Momose, Shun‐ichi Ohba, Kyohei Kurosawa, Akiko Harakawa, Hiroyuki Inoue, Minori Senoo, Daisuke Tatsuda, Hikaru Abe, Atsushi Masamune, Manabu Kawada   +11 more
wiley   +1 more source

Neoadjuvant Therapy‐Induced Remodeling in Pancreatic Ductal Adenocarcinoma: Multimodal Spatial Analysis and Prognosis

Cancer Science, EarlyView.
Using integrated spatial pathomics and transcriptomics, we show that neoadjuvant therapy (NAT) in pancreatic ductal adenocarcinoma (PDAC) induces substantial tumor microenvironment remodeling that is not captured by tumor regression grading (TRG) alone.
Xiaofei Zhang, Ruoxin Lan, Danting Li, Yongjun Liu, Sonu Kalyan, Momin Iqbal, Nancy Liu, Jerry Zhang, Iman Hanna, Mala Gupta, Chaohui L. Zhao, Weiguo Liu, Jonathan Melamed, Michael Shusterman, Jessica Widmer, John Allendorf, Yao‐Zhong Liu   +16 more
wiley   +1 more source

Integrated multi-omics elucidates PRNP knockdown-mediated chemosensitization to gemcitabine in pancreatic ductal adenocarcinoma

Frontiers in Immunology
IntroductionPancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with an extremely poor prognosis. Gemcitabine (GEM), the standard first-line chemotherapeutic agent for PDAC, often fails due to the development of drug resistance ...
Bing Qi, Yuwei Wu, Ning Wang, Liumeng Duan, Yangbo Wei, Xuanrui Zhang, Jing Chen   +6 more
doaj   +1 more source

Cascade‐Targeted Nanoparticles for Enhanced Gemcitabine Delivery and Adenosine Metabolism Modulation to Overcome Treatment Resistance in Pancreatic Cancer [PDF]

Hongrui Fan, Hongyi Chen, Haolin Song, Chufeng Li, Yu Wang, Zhenhao Zhao, Qin Guo, Xuwen Li, Mingxuan Liu, Tao Sun, Chen Jiang   +10 more
openalex   +1 more source

Additional file 9 of Circular RNA circ-MTHFD1L induces HR repair to promote gemcitabine resistance via the miR-615-3p/RPN6 axis in pancreatic ductal adenocarcinoma

, 2022
Zhi‐Wen Chen, Jianfei Hu, Zuwei Wang, Cheng‐Yu Liao, Feng‐Ping Kang, Cai‐Feng Lin, Yi Huang, Long Huang, Yifeng Tian, Shi Chen   +9 more
openalex   +1 more source

Brentuximab vedotin and radiotherapy for CD30‐positive cutaneous T‐cell lymphoma – a retrospective multicenter analysis

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives While brentuximab vedotin (BV) and radiotherapy (RTx) are established treatment options for CD30‐positive cutaneous T‐cell lymphoma (CTCL), data on their simultaneous or sequential use regarding efficacy and tolerability remain scarce.
Patrick Schummer, Caroline Glatzel, Philipp Schrüfer, Ingulf Lawrenz, Gabor Dobos, Ulrike Wehkamp, Svea Hüning, René Stranzenbach, Jan P. Nicolay, Matthias Goebeler, Marion Wobser   +10 more
wiley   +1 more source

Additional file 21 of m6A eraser FTO impairs gemcitabine resistance in pancreatic cancer through influencing NEDD4 mRNA stability by regulating the PTEN/PI3K/AKT pathway

, 2023
Kai Lin, Endi Zhou, Ting Shi, Siqing Zhang, Jinfan Zhang, Ziruo Zheng, Yuetian Pan, Wentao Gao, Yabin Yu   +8 more
openalex   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Inhibitory Effect of Oat Bran Ethanol Extract on Survival and Gemcitabine Resistance of Pancreatic Cancer Cells [PDF]

, 2019
Myoungjae Kim, Jeong‐Geon Mun, Hyun Jin Lee, So-Ri Son, Mi‐Ja Lee, Ji‐Ye Kee   +5 more
openalex   +1 more source

A Novel Gemcitabine-Resistant Gallbladder Cancer Model Provides Insights into Molecular Changes Occurring during Acquired Resistance [PDF]

, 2023
Luis Vergara-Gómez, Carolina Bizama, Jun Zhong, Kurt Buchegger, Felipe Suárez, Lorena Rosa, Carmen Ili, Helga Weber, Javiera Obreque, Karena Espinoza, Gabriela M. Repetto, Juan Carlos Roa, Pamela Leal, Patricia García   +13 more
openalex   +1 more source