Results 231 to 240 of about 3,125,328 (279)

Hydrogel-mediated mitochondrial reprogramming for inducing cell death: a novel approach to overcoming gemcitabine resistance in pancreatic ductal adenocarcinoma. [PDF]

Mater Today Bio
Zhao Q, Liu S, Bi T, Wang T, Chen L, Huang J, Yang X, Dai X, Liu Z, Sun Q.   +9 more
europepmc   +1 more source

Correction to: Natural compound Oblongifolin C confers gemcitabine resistance in pancreatic cancer by downregulating Src/MAPK/ERK pathways. [PDF]

Cell Death Dis
Li Y, Xi Z, Chen X, Cai S, Liang C, Wang Z, Li Y, Tan H, Lao Y, Xu H.   +9 more
europepmc   +1 more source

Bioinformatics-based screening of key genes associated with gemcitabine resistance in advanced pancreatic ductal adenocarcinoma. [PDF]

Transl Cancer Res
Hu K, Hasegawa K, Zhou G.
europepmc   +1 more source

SMARCA4‐Deficient Undifferentiated Thoracic Tumor: Clinical Features and Prognosis of a Case Series and Literature Review

The Clinical Respiratory Journal, Volume 20, Issue 1, January 2026.
Our manuscript presents detailed presentations of case series of thoracic SMARCA4‐UT, and we report a unique case of diaphragmatic metastases and, interestingly, the occurrence of brain metastasis in one patient, which is a rare phenomenon in SMARCA4‐UT.
Fangzhen Shan, Shuntao Liang, Youwen Zhang, Wei Wu, Guangxia Yang, Mei Yan, Xuemei Zhang, Yumao Miao, Linlin Liu, Jingjing Cai, Zhitao Shi, Bangdong Liu, Nannan Zhang   +12 more
wiley   +1 more source

Mirvetuximab Soravtansine: Mechanism of Action, Clinical and Translational Science

Clinical and Translational Science, Volume 19, Issue 1, January 2026.
ABSTRACT Mirvetuximab soravtansine (MIRV) is an antibody‐drug conjugate (ADC) composed of the DM4 payload conjugated to a folate receptor α (FRα)‐targeting antibody via the cleavable sulfo‐SPDB linker. MIRV targets and binds to FRα with high affinity and specificity, releasing the DM4 payload intracellularly following MIRV‐FRα complex internalization ...
Rajeev Menon, Emarjola Bako, Shuhan Liu, James Stec, Sheetal Thakur, Emily Deutschman, Olga Ab, Shweta Jain   +7 more
wiley   +1 more source

CDCA7 enhances STAT3 transcriptional activity to regulate aerobic glycolysis and promote pancreatic cancer progression and gemcitabine resistance. [PDF]

Cell Death Dis
Zheng D, Deng Y, Deng L, He Z, Sun X, Gong Y, Shi B, Lu D, Yu C.   +8 more
europepmc   +1 more source

Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications

Journal of Pineal Research, Volume 78, Issue 1, January 2026.
ABSTRACT Gastrointestinal (GI) cancers remain a leading cause of global morbidity and mortality, necessitating novel therapeutic strategies. Melatonin (MEL), an indoleamine with pleiotropic biological activities, has emerged as a promising adjuvant in oncology due to its antiproliferative, proapoptotic, and antioxidant properties.
Maciej Gonciarz, Benita Wiatrak, Iga Lombard, Łukasz Konecki, Joanna Sarbinowska   +4 more
wiley   +1 more source

Folliculotropic Mycosis Fungoides: Update on Diagnosis, Clinicopathological Stage, and Management

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
Folliculotropic mycosis fungoides (FMF) is a rare subtype of MF, characterized by prominent folliculotropism in histopathology. Clinically, FMF exhibits polymorphic presentations, mainly including follicular papules, plaques, alopecia, and other nonspecific lesions, with a predilection for the head and neck region, leading to frequent misdiagnosis ...
Xingyu Li, Jie Liu, Nicola Pimpinelli
wiley   +1 more source

Acyl-CoA thioesterase 8 induces gemcitabine resistance via regulation of lipid metabolism and antiferroptotic activity in pancreatic ductal adenocarcinoma. [PDF]

Acta Pharmacol Sin
Li BR, Wang T, Hu HF, Wu D, Zhou CJ, Ji SR, Zhuo QF, Li Z, Wang ZL, Fan GX, Jing DS, Yu CY, Qin Y, Chen XM, Xu JF, Xu XW.   +15 more
europepmc   +1 more source

Health Benefits and Therapeutic Potential of Quercetin

Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.
Quercetin, a polyphenolic compound prevalent in many fruits, vegetables, and other dietary sources, has attracted considerable interest due to its extensive health benefits. This review examines its diverse biological properties, particularly its antioxidant and anti‐inflammatory effects. The study integrates recent scientific findings to elucidate the
Mahendra Aryal, Kim Wei Chan
wiley   +1 more source