PLoS ONEGemcitabine is commonly used in the standard first-line treatment of urothelial carcinoma (UC); however, the emergence of drug resistance significantly limits its clinical benefit.
Kun-Lin Hsieh +6 more
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EGR1 mediates MDR1 transcriptional activity regulating gemcitabine resistance in pancreatic cancer
BMC CancerBackground Gemcitabine is a cornerstone drug for the treatment of all stages of pancreatic cancer and can prolong the survival of patients with pancreatic cancer, but resistance to gemcitabine in pancreatic cancer patients hinders its efficacy.
Zhe Yang +5 more
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Epigenetic Activation of the CMTM6‐IGF2BP1‐EP300 Positive Feedback Loop Drives Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma [PDF]
Advanced SciencePancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with a dismal prognosis. Gemcitabine‐based chemotherapy has emerged as a first‐line treatment for PDAC.
Ying‐Qin Zhu +13 more
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TRIM59/RBPJ positive feedback circuit confers gemcitabine resistance in pancreatic cancer by activating the Notch signaling pathway [PDF]
Cell Death and DiseasePancreatic cancer (PC) is one of the most lethal malignant tumors that lacks effective treatment, and gemcitabine-based chemoresistance occurs frequently. Therefore, new therapeutic strategies for PC are urgently needed.
Shiyu Chen +8 more
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Cell Death and Disease, 2021 Exosomes are carriers of intercellular information that regulate the tumor microenvironment, and they have an essential role in drug resistance through various mechanisms such as transporting RNA molecules and proteins.
Ting Li +9 more
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cNEK6 induces gemcitabine resistance by promoting glycolysis in pancreatic ductal adenocarcinoma via the SNRPA/PPA2c/mTORC1 axis [PDF]
Cell Death and DiseaseResistance to gemcitabine in pancreatic ductal adenocarcinoma (PDAC) leads to ineffective chemotherapy and, consequently, delayed treatment, thereby contributing to poor prognosis. Glycolysis is an important intrinsic reason for gemcitabine resistance as
Ge Li +14 more
doaj +2 more sources
Mathematical strategies for predicting resistant subpopulations from scRNAseq data of a PANC-1 3D tissue model: Insight into gemcitabine resistance and TGFB1-induced invasion and EMT. [PDF]
Comput Struct Biotechnol JCaliskan A +5 more
europepmc +2 more sources
APOBEC3 upregulation drives gemcitabine resistance. [PDF]
Nat CancerMaciejowski J, Mohamed T.
europepmc +2 more sources