Results 141 to 150 of about 4,046,080 (225)

Systems biology of proteins expressed during the Moniliophthora perniciosa necrotrophic phase : S01P12 [PDF]

, 2013
The fungus Moniliophthora perniciosa, the etiologic agent of witches' broom disease of cacao (Theobroma cacao L.) has a hemibiotrophic life cycle, with a biotrophic and a necrotrophic phase.
Bonatto, Diego, Feltes, B.C., Gomes, Dayane Santos, Micheli, Fabienne, Silva, F.R.   +4 more
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The emerging role of CAMK1D in diabetes, metabolism and feeding behaviours: A mechanistic systematic review

Clinical and Translational Discovery, Volume 6, Issue 1, February 2026.
This systematic review synthesizes evidence from published studies, GWAS and grey literature (patents) to show that CAMK1D is implicated in diabetes, obesity, insulin resistance and altered feeding behaviours, with diagnostic potential and mechanistic relevance through regulatory binding and tissue‐specific effects.
Livio Tarchi, Annalisa Di Giacomo, Lorenzo Bonacchi, Andrea Di Santo, Paolo Rovero, Chiara Sassoli, Rachele Garella, Roberta Squecco, Gianluca Villa, Romina Nassini, Francesco De Logu, Tiziana Pisano, Valdo Ricca, Giovanni Castellini   +13 more
wiley   +1 more source

Chronic Granulomatous Disease: Clinical and Molecular Characterization of Brazilian Patients

The Journal of Gene Medicine, Volume 28, Issue 2, February 2026.
Chronic granulomatous disease is a rare inborn error of immunity characterized by the deficient production of reactive oxygen species in phagocytes, which are used in pathogen elimination. Affected individuals become susceptible to severe infections.
Leonardo Martinello da Rosa, Martha Braun da Rosa, Mariana de Sampaio Leite Jobim Wilson, Ida Vanessa Doederlein Schwartz, Fernanda Sperb‐Ludwig   +4 more
wiley   +1 more source

Análise comparativa entre as metodologias de PCR metilação-específica (MSP), Southern blot (SB) e FISH utilizadas no diagnóstico genético molecular de pacientes com suspeita clínica das síndromes de Prader-Willi ou Angelman

Clinical and Biomedical Research, 2016
Introdução: Prader-Willi (SPW) e Angelman (SA) são síndromes clinicamente distintas, causadas pela perda de expressão de genes na região cromossômica 15q11.2-q13, de origem paterna ou materna, respectivamente.
Bruna Oliveira, Letícia da Cunha Veber, Têmis Maria Félix, Mariluce Riegel, Isabel Cristina Bandeira da Silva, Carla Streit, Sandra Leistner-Segal   +6 more
doaj   +2 more sources

Variabilidade genética molecular em híbridos de Panicum maximum Jacq. avaliada por marcadores RAPD [PDF]

, 2011
Este trabalho foi realizado com o objetivo de caracterizar a diversidade genética molecular em híbridos de P. maximum Jacq.
BLUMA-MARQUES, A. C., CHIARI, L., JANK, L., LEGUIZAMON, G. O. de C.   +3 more
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Molecular diagnosis of haemophilia A: four novel variants identified in five patients [PDF]

, 2020
Aims/Context: Haemophilia A (HMA) is an X-linked bleeding disorder caused by reduced levels of the coagulation factor VIII (FVIII) due to alterations in the F8 gene. Decreased levels of FVIII activity leads to a loss of clotting activity and to bleeding (
Antunes, Ema, Certã, Rita, Cruz, Eugénia, Diniz, Maria João, Gonçalves, João, Kjollerstrom, Paula, Morais, Sara, Moreira, Isabel   +7 more
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Metabolomic Analysis of Phytophthora parasitica Growth in the Presence of β‐sitosterol Indicates Adaptive Mechanisms Modulated by Sterols

Journal of Basic Microbiology, Volume 66, Issue 2, February 2026.
ABSTRACT Phytophthora parasitica is a generalist phytopathogenic oomycete that infects a series of crops with great economic interest, including tomato, tobacco, and citrus species. Sterols are essential lipids in eukaryotic organisms, playing a fundamental role in the structure and function of the cell membrane.
Pâmela Ponce Martins, Evandro Silva, Marcus Vinicius Fernandes Prior, João Marcos Martins Ferreira, Marina Erê Pimenta Santos, Flavia Rodrigues Alves Patrício, Taicia Pacheco Fill, Jorge Maurício Costa Mondego   +7 more
wiley   +1 more source

Climatic Variables and Virulence May Contribute to the Population Dynamics of Pyricularia oryzae at Local Scale

MicrobiologyOpen, Volume 15, Issue 1, February 2026.
The Italian population structure of P. oryzae was analyzed using SSR genotyping to identify possible determinants shaping its local genetic diversity, including spatial, temporal, environmental, and biological factors. ABSTRACT Rice blast disease, caused by Pyricularia oryzae Cavara, is the most threatening rice pathogen in Italy.
Simone Bosco, Fabiano Sillo, Paola Ruffa, Lisa Bergonzi, Daniele Tenni, Pamela Abbruscato, Daniela Torello Marinoni, Marco Romani, Davide Spadaro   +8 more
wiley   +1 more source

Presumed TP53 mosaicism: variants detected using a NGS hereditary cancer multigene panel [PDF]

, 2019
Aims/Context: NGS multigene panels are routinely used to identify germline pathogenic variants in cancer susceptibility genes. In addition, NGS allows the identification of low-level mosaicism events that may not be detectable by conventional Sanger ...
Gonçalves, João, Rodrigues, Márcia, Rodrigues, Pedro, Silva, Catarina, Theisen, Patrícia, Vieira, Luís   +5 more
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Integrative Single‐Cell Analysis Reveals Targetable Vacuole Membrane Protein 1‐Mediated Mechanism of Tumor Angiogenesis in Glioblastoma

MedComm, Volume 7, Issue 2, February 2026.
VMP1 promotes angiogenesis in glioblastoma (GBM) through VEGFA‐VEGFR2 signaling and activation of endothelial cells. The FDA‐approved anti‐VEGFA antibody, bevacizumab (BEV), can counteract VMP1's tumor‐promoting effect in GBM. Targeting VMP1 or its associated pathways could be a new therapeutic strategy, either alone or in combination with BEV.
Lei Jin, Bo Chen, Junbo Liao, Wenlong Guo, Zhiyuan Zhu, Salida Ali, Gilberto Ka‐Kit Leung, Peng Wang, Karrie M. Kiang   +8 more
wiley   +1 more source