Results 1 to 10 of about 15,674 (182)

Colorectal cancer biomarkers and their impact on the clinical practice

Brazilian Journal of Oncology, 2021
Colorectal cancer (CRC) holds third place in the global ranking of malignancies worldwide. Patients with CRC commonly show distinct outcomes and treatment responses due to their biological features and tumoral biomarkers.
James Crespo, Ana Paula Victorino, Kelly Araujo, Luiz Henrique Araujo, Fernando Meton de Alencar Camara Vieira   +4 more
doaj   +1 more source

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

Downregulation of FeSOD-A expression in Leishmania infantum alters trivalent antimony and miltefosine susceptibility

Parasites & Vectors, 2021
Background Superoxide dismutase (SOD), a central component of the antioxidant defence system of most organisms, removes excess superoxide anions by converting them to oxygen and hydrogen peroxide. As iron (Fe) SOD is absent in the human host, this enzyme
Ana Maria Murta Santi, Paula Alves Silva, Isabella Fernandes Martins Santos, Silvane Maria Fonseca Murta   +3 more
doaj   +1 more source

Transcriptomic analysis of benznidazole-resistant and susceptible Trypanosoma cruzi populations

Parasites & Vectors, 2023
Background Chagas disease (CD), caused by the parasite Trypanosoma cruzi, is a serious public health concern in Latin America. Nifurtimox and benznidazole (BZ), the only two drugs currently approved for the treatment of CD, have very low efficacies in ...
Davi Alvarenga Lima, Leilane Oliveira Gonçalves, João Luís Reis-Cunha, Paul Anderson Souza Guimarães, Jeronimo Conceição Ruiz, Daniel Barbosa Liarte, Silvane Maria Fonseca Murta   +6 more
doaj   +1 more source

M. bovis BCG Moreau N-Terminal Loss Leads to a Less Stable Dodecin With Lower Flavin Binding Capacity

Frontiers in Cellular and Infection Microbiology, 2021
Tuberculosis still remains a concerning health problem worldwide. Its etiologic agent, Mycobacterium tuberculosis, continues to be the focus of research to unravel new prophylactic and therapeutic strategies against this disease.
Marcos Gustavo Araujo Schwarz, Bianca Gallart Cinelli Luzes, Paloma Rezende Correa, Antônio José da Silva-Gonçalves, Lucas de Almeida Machado, Ana Carolina Ramos Guimarães, Leila Mendonça-Lima   +6 more
doaj   +1 more source

Biorrevelações: testes de ancestralidade genética em perspectiva antropológica comparada

Horizontes Antropológicos, 2011
É cada vez maior o número de empresas que comercializam testes de ancestralidade genética a partir do DNA, sobretudo, na América do Norte. Tal fenômeno tem atraído a atenção das ciências sociais, em particular da antropologia.
Verlan Valle Gaspar Neto, Ricardo Ventura Santos   +1 more
doaj   +1 more source

Brief history of Eucalyptus breeding in Brazil under perspective of biometric advances

Ciência Rural, 2016
: Forest breeding is a science that has been developing in Brazil since 1941 being the Eucalyptus a highlighted genus in this scenario. In a global scene, Brazil is displayed prominently in productivity of Eucalyptus planting, due to favorable ...
Carla Aparecida de Oliveira Castro, Rafael Tassinari Resende, Leonardo Lopes Bhering, Cosme Damião Cruz   +3 more
doaj   +1 more source

Resistome in Lake Bolonha, Brazilian Amazon: Identification of Genes Related to Resistance to Broad-Spectrum Antibiotics

Frontiers in Microbiology, 2020
Resistance to antibiotics is one of the most relevant public health concerns in the world. Aquatic environments play an important role because they are reservoirs for antibiotic resistance genes and antibiotic-resistant strains, contributing to the ...
Jorianne Alves, Larissa Dias, Jackeline Mateus, Joana Marques, Diego Graças, Rommel Ramos, Lucy Seldin, Isabel Henriques, Isabel Henriques, Artur Silva, Adriana Folador   +10 more
doaj   +1 more source

Functionomics: the analysis of a postgenomic concept on the basis of pregenomic pharmacological studies in smooth muscle

Anais da Academia Brasileira de Ciências, 2009
The term functionomics (Amin 2003, Neumann et al. 2004) refers to a postgenomic integrated Systems Biology (Attur et al. 2002) using a multidimensional approach for cells, tissues and organs.
Aron Jurkiewicz, Afonso Caricati-Neto, Neide H. Jurkiewicz   +2 more
doaj   +1 more source

Progresso científico em melhoramento animal no Brasil na primeira década do século XXI Scientific progress in animal breeding during the first decade of XXI century

Revista Brasileira de Zootecnia, 2010
O Brasil é um dos lideres mundiais em produção de animais de interesse zootécnico. Porém, para manter este status, precisa investir grandemente em pesquisas que visem aumentar a produtividade animal.
Raysildo Barbosa Lôbo, Thereza Cristina Bório dos Santos Calmon de Bittnecourt, Luís Fernando Batista Pinto   +2 more
doaj   +1 more source