Results 21 to 30 of about 11,477 (124)

A Non‐Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development

Advanced Science, EarlyView.
SMAD4 is identified as a guardian of 3D genome architecture in lung squamous cell carcinoma. Loss of SMAD4 unleashes EP300 at chromatin loop anchors, strengthening enhancer–promoter looping and H3K27ac at the SOX2 locus to drive aberrant SOX2 activation and tumor cell proliferation.
Qian Tang, Chen Lian, Xinyan Han, Xuhan Zhang, Zihan Wang, Boyu Wang, Taoyu Zhu, Xinrui Lin, Xiaolei Wang, Yaping Xu, Manyu Xiao, Zijin Wang, Junming Li, Silin Chen, Yunze Wang, Yufei Liu, Songsong Li, Zuolin Shen, Xi Lu, Xueqi Han, Yilu Zhou, Mingyang Xiao, Jiayi Ran, Xiaoran Cao, Xinyi Xu, Hugo Sámano‐Sánchez, Alfredo Rodríguez, Lian Wang, Shuifang Chen, Zhanyu Xu, Shirong Zhang, Nuo Yang, Yong Tang, Jian Liu   +33 more
wiley   +1 more source

Genetic Risk and High Burden of Depression and Suicide in the Maya‐Mestizo Population of Yucatán, México

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Major depression and suicide are critical public health concerns, particularly in underrepresented populations with unique genetic and sociocultural contexts. The Maya‐mestizo population presents the highest suicide rates in the country but remains understudied in psychiatric genetics. This study evaluated the association between three genetic
Marta Menjivar, Erandi Bravo, Margarita Rivera‐Balancan, Barbara Itzel Pena Espinoza   +3 more
wiley   +1 more source

A cost‐effective DNA extraction protocol for long‐read sequencing in non‐model plants

Applications in Plant Sciences, EarlyView.
Abstract Premise Third‐generation sequencing has revolutionized genomics, enabling in‐depth analysis of genome sequence, structure, and epigenetic features. Yet, extracting high‐quality DNA for long‐read sequencing remains a bottleneck—particularly in non‐model plants, such as mature trees growing in natural environments, which often contain abundant ...
Sofia Gaischuk, Cintia F. Marchetti, Ezequiel Petrillo, Fernando A. Rabanal, Detlef Weigel, Nicolás Bellora, M. Verónica Arana   +6 more
wiley   +1 more source

Assessment of the adjuvant activity of mesoporous silica nanoparticles in recombinant Mycoplasma hyopneumoniae antigen vaccines

Heliyon, 2017
The adjuvant potential of two mesoporous silica nanoparticles (MSNs), SBa-15 and SBa-16, was assessed in combination with a recombinant HSP70 surface polypeptide domain from Mycoplasma hyopneumoniae, the etiological agent of porcine enzootic pneumonia ...
Veridiana Gomes Virginio, Natalia Costantin Bandeira, Fernanda Munhoz dos Anjos Leal, Marcelo Lancellotti, Arnaldo Zaha, Henrique Bunselmeyer Ferreira   +5 more
doaj   +1 more source

The Global Parkinson's Disease Genetics (GP2) Genome Browser

Movement Disorders, EarlyView.
Abstract Background Large‐scale sequencing initiatives have generated extensive genomic resources essential for variant interpretation, yet their effective use often requires bioinformatics expertise. To support identification of Parkinson's disease (PD) risk and disease‐causing variants, we developed an open‐access, summary‐level genomic data browser.
Zih‐Hua Fang, Riley H. Grant, Dan Vitale, Carlos F. Hernandez, Samantha Hong, Hampton L. Leonard, Mary B. Makarious, Lara M. Lange, Matthew Solomonson, Peter Heutink, Allison A. Dilliott, Kamalini Ghosh Galvelis, Mike A. Nalls, Andrew B. Singleton, Cornelis Blauwendraat, the Global Parkinson's Genetics Program (GP2)   +15 more
wiley   +1 more source

Past, present and future of local crop evolution

PLANTS, PEOPLE, PLANET, EarlyView.
Promoting agrobiodiversity is a promising strategy for mitigating the negative effects of climate change on global food security. We highlight the central role evolutionary processes play in harnessing the potential of local crops by integrating genomics, archaeology, ethnobotany and traditional ecological knowledge (TEK).
Nataly Allasi Canales, Philippa Ryan, Amy Jackson, Hong Phuong Le, James Borrell, Aaron Davis, Rafal M. Gutaker   +6 more
wiley   +1 more source

Modulation of miR-429 during osmotic stress in the silverside Odontesthes humensis

Frontiers in Genetics, 2022
Silverside fish inhabit marine coastal waters, coastal lagoons, and estuarine regions in southern South America. Although silversides are not fully adapted to freshwater, they can tolerate a wide range of salinity variations.
Antônio D. Pagano, Bruna F. Barreto, William B. Domingues, Tony L. R. Silveira, Leandro S. Nunes, Eduardo B. Blodorn, Eduardo N. Dellagostin, Mariana H. Remião, Ricardo B. Robaldo, Vinicius F. Campos   +9 more
doaj   +1 more source

Endophytic fungi from two isolated Bethencourtia palmensis populations: metabolomic and bioactivity fingerprinting

Pest Management Science, EarlyView.
We compared two island populations of Bethencourtia palmensis and their culturable endophytic fungi, revealing distinct plant chemistries and a higher biopesticidal potential in the endophytic fungi from La Palma population along with high potential for the discovery of novel compounds.
Jorge Rojas López‐Menchero, Juan Imperial, Carmen Elisa Díaz, María Fe Andrés, Azucena González‐Coloma   +4 more
wiley   +1 more source

Genomics‐informed management of ex situ populations

Conservation Biology, EarlyView.
Abstract The European Association of Zoos and Aquariums (EAZA) manages insurance populations for hundreds of species through its EAZA ex situ programs (EEPs). EEPs help safeguard against extinction in the wild and provide source populations for genetic rescue programs.
Cock van Oosterhout, Philippe Helsen, Elmar Fienieg, Claudia Fontsere, Linett Rasmussen, Mirte Bosse, Zjef Pereboom, Christina Hvilsom, Hernán E. Morales   +8 more
wiley   +1 more source

Pest‐preservation paradox among insects

Conservation Biology, EarlyView.
The pest‐preservation paradox is a non‐binary perspective that insects range from those that are harmful and requiring management on the one side, to those requiring conservation intervention on the opposite end of the spectrum. Importantly, the vast majority of insects occur somewhere in the center of the two extremes, and their position along the ...
Michael J. Samways, Charl Deacon, René Gaigher, James S. Pryke   +3 more
wiley   +1 more source