Results 81 to 90 of about 770,818 (335)

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

Advanced Science, EarlyView.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen   +5 more
wiley   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Gender based Violence in Rural Areas in South Africa Impacts on Home based Learning during the Coronavirus Disease 2019 Pandemic

, 2022
Urmilla Bob, Suveshnee Munien, Amanda Gumede   +2 more
openalex   +1 more source

Press coverage of same-sex domestic violence cases in Spain [PDF]

, 2016
Introduction. Spanish media have covered several cases of violence in same-sex couples in recent years. Reporting on this phenomenon raises questions about how to approach a reality that had remained hidden until recently. Method. The aim of this article
Carratalá Simón, Adolfo
core   +2 more sources

The Tumor‐to‐Endothelial Transfer of FTO Promotes Vascular Remodeling and Metastasis in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
Integrated omics analysis of matched primary and liver metastatic NPC tumors reveals a unique NOTCH1+ CSC subpopulation exhibiting enhanced stemness properties and tumorigenic capacity. With in vitro and in vivo assays, exosomal transfer of tumor‐derived FTO from NOTCH1+ cells to the endothelium promotes vascular permeability and metastatic potential ...
Chun Wu, Xuefei Liu, Liwen Gu, Jingru Lian, Yuting Wang, Yixin Cheng, Lianhui Duan, Guanyin Huang, Siqi Chen, Boxi Zhao, Sailan Liu, Yufan Yang, Shuqian Zheng, Zijian Lu, Wanping Guo, Jianyang Hu, Wenjing Wang, Zhixiang Zuo, Haiqiang Mai, LinQuan Tang, Songfa Zhang, Feiqiu Wen, Xin Hong, Ling Guo   +23 more
wiley   +1 more source

Understanding the nature and etiology of intimate partner violence and [PDF]

, 2011
Theoretical perspectives underlying hypotheses about the nature and etiology of intimate partner violence are important as they inform professionals how they should best respond to reduce or eliminate this social problem.
Dixon, Louise
core  

The SASA Study: A community mobilisation intervention to prevent violence against women and reduce HIV risk in Kampala, Uganda [PDF]

, 2015
Gender based violence, including violence by an intimate partner, is a major global human rights and public health problem, with important connections with HIV risk.
Abramsky, Tanya, Devries, Karen
core   +2 more sources

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

Advanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng, Zongbi Yi, Jing Hu, Jiali Li, Yu Xu, Xiuli Guo, Qian Ji, Kaixiang Feng, Ying Zhang, Sirui Bai, Yushuang Tan, Yufei Yan, Linzhi Han, Jing Jiang, Tengfei Wang, Xiang Wang, Ziqing Zhan, Ruiying Huang, Jinfang Zhang, Conghua Xie, Binghe Xu   +20 more
wiley   +1 more source

PRO-Mueve Relaciones Sanas – A Gender-Based Violence Prevention Program for Adolescents: Assessment of Its Efficacy in the First Year of Intervention [PDF]

, 2022
Lilián Velasco Furlong, Helena Thomas-Currás, Yolanda Pastor Ruiz, Aroa Arcos-Rodríguez   +3 more
openalex   +1 more source

Gender-based violence and efforts to address the phenomenon: Towards a church public pastoral care intervention proposition for community development in Zimbabwe

HTS Teologiese Studies/Theological Studies, 2019
Gender-based Violence (GBV) is a huge concern in many African countries such as Zimbabwe despite the preventative and mitigatory interventions that have been proposed and implemented by various stakeholders.
Vhumani Magezi, Peter Manzanga
doaj   +1 more source