Results 91 to 100 of about 45,888 (262)

Outcomes and Experience of Gender-Confirming Vulvoplasty: A Systematic Review

Genital gender-affirming surgery, or bottom surgery, is a medically necessary treatment for some transgender and gender diverse (TGD) individuals. Techniques and outcomes of penile inversion vaginoplasty are the most well-documented type of feminizing ...
Kesmodel, Ulrik Schiøler, Aaen, Emma Krogsgaard, Pop, Maria Lucia, Højgaard, Astrid Ditte   +3 more
core   +1 more source

Development of the BODY-Q Chest Module Evaluating Outcomes Following Chest Contouring Surgery

, 2018
BACKGROUND: Plastic surgery to improve chest appearance is becoming increasingly popular. The BODY-Q is a patient-reported outcome (PRO) instrument designed for weight loss and/or body contouring.
Kaur, Manraj, Maarten Hoogbergen, René Klinkby Støving, Juhl, Claus Bogh, Panchapakesan, Vivek, Tim C. van de Grift, Andrea L. Pusic, Craig Fielding, Margriet G. Mullender, Poulsen, Lotte, Lotte Poulsen, McLean, Hugh, Mullender, Margriet G, Hoogbergen, Maarten, Moliver, Clayton, Jens Ahm Sørensen, Giancarlo McEvenue, Geerards, Daan, Anne F. Klassen, Michael Rose, Sørensen, Jens Ahm; id_orcid, Pusic, Andrea L, Vivek Panchapakesan, Hugh McLean, Rose, Michael, Lorenzen, Mike Mikkelsen, Mike Mikkelsen Lorenzen, Jussi P. Repo, Støving, René Klinkby, Claus Bogh Juhl, Støving, René Klinkby; id_orcid, Repo, Jussi P, Klassen, Anne F, Fielding, Craig, Sørensen, Jens Ahm, Clayton Moliver, Daan Geerards, van de Grift, Tim C, Manraj Kaur, McEvenue, Giancarlo   +39 more
core   +1 more source

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

Assessing Gender: An Exploration of Transgender Individuals' Experiences of Assessments for Hormone Therapy or Surgery in Nova Scotia

, 2019
Transgender individuals living in Nova Scotia and wishing to undergo gender-confirming hormone therapy or surgery must participate in a mandatory mental health assessment to determine whether they meet the diagnostic criteria for gender dysphoria.
Long, Brittany
core  

Options for Fertility Treatments for Trans Women in Germany

, 2019
Fertility preservation in trans women is a crucial but thus far neglected component in the gender confirming treatment in Germany. It is difficult for trans women to access reproductive health care because centers offering treatment, psychological ...
Florian Schneider, Sabine Kliesch, Stefan Schlatt, Nina Neuhaus, Laura Heckmann, Bettina Scheffer, Jennifer Dabel   +6 more
core   +1 more source

Gender Identity, Hormone Therapy, and Cardiovascular Disease Risk

, 2020
Transgender individuals represent a medically underserved and under researched population. There is a growing number of studies illustrating the importance of hormone therapy treatments in transgender men and women to assist ameliorating gender dysphoria
Martinez, Claudia, Haque, Tahir, Kolber, Michael, Schneiderman, Neil, Rikhi, Rishi, Hurwitz, Barry E, Brown, Todd T, Fazal, Amara   +7 more
core   +1 more source

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

Pedicled flaps versus free radial forearm flap for phalloplasty in female to male gender-confirming surgery: a systematic review

Background: The field of gender-affirming surgery is rapidly evolving, with plastic surgery units worldwide increasingly offering these services. Phalloplasty is a critical component of female-to-male (FTM) transition, providing significant psychological
Kathiravelupillai, Senthooran, Mitchell, Sebastian, Khajuria, Ankur, Zien, Ming, Netshiongolwe, Thendo, Subbiah, Praveen   +5 more
core   +1 more source

NFYB Integrates Hormonal Signals into Tissue Allometry by Promoting Protein Biosynthesis

Advanced Science, EarlyView.
In the American cockroach, NFYB acts as a spatiotemporin that translates distinct hormonal cues into tissue‐specific allometry. Juvenile hormone activates NFYB in the early fat body, while 20‐hydroxyecdysone induces it in late wing pads. NFYB then promotes protein biosynthesis via core translational machinery, driving differential growth across the ...
Fangfang Liu, Shiming Zhu, Sishi Xia, Xiaoshuai Zhang, Qin Li, Zhanquan Zeng, Yuqing Liu, Wanyin Liang, Guanyu Zhou, Erxia Du, Suning Liu, Sheng Li   +11 more
wiley   +1 more source

Noninvasive Characterization of Tumor Heterogeneity in HNSCC: From Clinical Utility to Biological Correlates

Advanced Science, EarlyView.
This study establishes a CT‐based radiomics framework to quantify intratumoral heterogeneity (ITH) in HNSCC. Using unsupervised clustering, tumor ROIs and VOIs are analyzed to calculate 2D/3D ITH scores. The score shows strong predictive value for prognosis and immunotherapy response, and is associated with tumor metabolism and immune microenvironment,
Xinwei Chen, Rui Liu, Yuan Zhou, Yin Xiao, Chengmin Feng, Lin Chen, Yanshi Li, Mengna Wang, Zhaobo Cheng, Yuxi Luo, Long Liu, Lijing Niu, Yue Xiang, Juan Peng, Guohua Hu, Min Pan   +15 more
wiley   +1 more source