Results 101 to 110 of about 3,568,884 (345)

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

Gender Differences in the Association Between Obstructive Sleep Apnea and Diabetes

, 2021
Ye Tao, Xiaoli Li, Guang Yang, Lingling Wang, Junsong Lian, Zheng Chang   +5 more
openalex   +2 more sources

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Gender differences in the impact of population-level alcohol policy interventions: evidence synthesis of systematic reviews [PDF]

, 2016
Background: Consistent review-level evidence supports the effectiveness of population-level alcohol policies in reducing alcohol-related harms. Such policies interact with well-established social, cultural and biological differences in how men and women ...
Amos, Annandale, Babor, Bambra, Beaglehole, Bergen, Bolier, Bonell, Booth, Borsari, Brennan, Brown, Bryden, Campbell, Cashman, Champion, D'Onise, Daly, Daykin, Derzon, Ditter, Doyal, Elder, Elder, Elder, Elder, Emslie, Emslie, Emslie, Emslie, Erke, Erol, European Association of Science Editors, Fletcher, Foxcroft, Foxcroft, Foxcroft, Goss, Greaves, Hahn, Hahn, Hale, Himmelweit, Holmes, Holmes, Holmila, Hughes, Jackson, Janer, Janssen, Jones, Kazemi, Ker, Keyes, Killoran, Kuntsche, Lachenmeier, Langford, Lemstra, Leon, Loveland-cherry, Lyons, Martens, Martineau, McCartney, Middleton, Moreira, Nolen-Hoeksema, Ostlin, Ostlin, Payne, Petrie, Phillips, Plant, Pollack, Pollack, Popova, Popova, Probst, Rammohan, Reavley, Rodriguez, Runnels, Russell, Schmidt, Scholes-Balog, Scott-Sheldon, Sen, Sen, Shipton, Shults, Smith, Snyder, Stead, Teesson, True, Visser, Visser, Wagenaar, Wagenaar, Webb, Welch, Wilsnack, Wilsnack, Wilsnack, Wilsnack, Wood   +106 more
core   +3 more sources

Prediction Model for Etiologic Differentiation of Isolated Vestibular Syndrome in Emergency Settings

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to develop and validate a predictive model for differentiating central from peripheral etiologies in patients with isolated vestibular syndrome (VS). Methods In this multicenter retrospective cohort study, 506 patients with isolated VS from five hospitals were divided into derivation (n = 301) and validation (n = 205)
Guo Wenting, Du Liping, Yang Yi, Hu Jin, Ye Bijun, Wang Jianer, Liu Shuangsi, Guo Shunyuan, Cai Xiaofeng, Wang Huiyuan, Wu Bin, Yu Xiang, Shi Tianming   +12 more
wiley   +1 more source

Clinical Characteristics and Outcomes of Early‐Onset Versus Late‐Onset LGI1‐Antibody Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Leucine‐rich glioma‐inactivated 1 antibody (LGI1‐Ab) encephalitis predominantly affected older individuals, but has also been reported in younger patients. However, the demographic, clinical, and prognostic characteristics of early‐onset LGI1‐Ab encephalitis have yet to be systematically elucidated. This study aims to systematically
Yu Kong, Shasha Yu, Jing Zhang, Yu Zu, Yujing Zhang, Jing Lv, Xuyang Cao, Xuedan Feng   +7 more
wiley   +1 more source

Gender Differences in Smoking Among an Urban Emergency Department Sample. [PDF]

, 2019
BackgroundUrban emergency department (ED) patients have elevated smoking and substance use compared with the general population. We analyzed gender differences in smoking among an urban ED sample and assessed the contribution of substance use ...
Alter, Harrison J, Caetano, Raul, Cunradi, Carol B, Lee, Juliet, Pagano, Anna   +4 more
core  

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source

Trends in gender differences in accidents mortality [PDF]

This study tests five hypotheses concerning trends in gender differences in accidents mortality and accident-related behavior, using data for the US, UK, France, Italy, and Japan, 1950-98.
Christopher McCloskey, Inga Earle, Ingrid Waldron   +2 more
core  

The Relationship Between Inflammation and Central Nervous System in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aim Multiple sclerosis is an autoimmune demyelination disease that is seen especially in the young population and has a progressive course, causing motor, sensory, and cognitive deficits. In the literature, the pathogenesis of MS disease and the interconnection between the immune and central nervous system in the disease have not been fully ...
Gamze Ansen, Ali Behram Salar, Abdulkadir Ermis, Erkingul Birday, Lutfu Hanoglu, Bayram Ufuk Sakul   +5 more
wiley   +1 more source