Results 1 to 10 of about 18,963,221 (356)
Sex Differences in Immunity to Viral Infections
Frontiers in Immunology, 2021 The ongoing COVID-19 pandemic has increased awareness about sex-specific differences in immunity and outcomes following SARS-CoV-2 infection. Strong evidence of a male bias in COVID-19 disease severity is hypothesized to be mediated by sex differential ...
H. Jacobsen, S. Klein
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Biology of Sex Differences, 2023 Background Mammalian gonadal sex is determined by the presence or absence of a Y chromosome and the subsequent production of sex hormones contributes to secondary sexual differentiation.
Victorya Richardson +2 more
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Uncovering sex differences of rodent microglia
Journal of Neuroinflammation, 2021 There are inherent structural and functional differences in the central nervous systems (CNS) of females and males. It has been gradually established that these sex-specific differences are due to a spectrum of genetic, epigenetic, and hormonal factors ...
Jinming Han +4 more
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Biology of Sex Differences, 2023 Background Damage to the cerebral vasculature can lead to vascular contributions to cognitive impairment and dementia (VCID). A reduction in blood flow to the brain leads to neuropathology, including neuroinflammation and white matter lesions that are a ...
Charly Abi-Ghanem +14 more
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Biology of Sex Differences, 2023 Background and aim Sex differences in atherosclerosis have been described with female plaques being mostly perceived as stable and fibrous. Sex-specific mechanisms such as mosaic loss of the Y chromosome in men have been linked to cardiovascular health ...
Michele F. Buono +11 more
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Sex at the interface: the origin and impact of sex differences in the developing human placenta
Biology of Sex Differences, 2022 The fetal placenta is a source of hormones and immune factors that play a vital role in maintaining pregnancy and facilitating fetal growth. Cells in this extraembryonic compartment match the chromosomal sex of the embryo itself.
Amy E. Braun +6 more
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Sex differences in type 2 diabetes: an opportunity for personalized medicine
Biology of Sex Differences, 2023 Over the past several decades, substantial ground has been gained in understanding the biology of sex differences. With new mandates to include sex as a biological variable in NIH-funded research, greater knowledge is forthcoming on how sex chromosomes ...
Meredith L. Johnson +4 more
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Sex Differences in Circadian Rhythms
Cold Spring Harbor Perspectives in Biology, 2022 Sex as a biological variable is the focus of much literature and has been emphasized by the National Institutes of Health, in part, to remedy a long history of male-dominated studies in preclinical and clinical research.
J. Walton +2 more
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Sex differences in mouse infralimbic cortex projections to the nucleus accumbens shell
Biology of Sex Differences, 2023 Background The nucleus accumbens (NAc) is an important region in motivation and reward. Glutamatergic inputs from the infralimbic cortex (ILC) to the shell region of the NAc (NAcSh) have been implicated in driving the motivation to seek reward through ...
Caroline S. Johnson +4 more
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Sex differences in pharmacokinetics predict adverse drug reactions in women
Biology of Sex Differences, 2020 Women experience adverse drug reactions, ADRs, nearly twice as often as men, yet the role of sex as a biological factor in the generation of ADRs is poorly understood.
I. Zucker, Brian J. Prendergast
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