Results 31 to 40 of about 1,927,890 (314)

Female-biased sexual dimorphism of corticotropin-releasing factor neurons in the bed nucleus of the stria terminalis

Biology of Sex Differences, 2019
Background The bed nucleus of the stria terminalis (BNST) contains the highest density of corticotropin-releasing factor (CRF)-producing neurons in the brain.
Katsuya Uchida, Hiroko Otsuka, Masahiro Morishita, Shinji Tsukahara, Tatsuya Sato, Kenji Sakimura, Keiichi Itoi   +6 more
doaj   +1 more source

Twenty years of sex and gender science in health research: a policy statement from the Organization for the Study of Sex Differences

Biology of Sex Differences
Sex and gender are fundamental determinants of health, disease risk, and treatment responses, yet they remain inconsistently and inadequately integrated into biomedical research.
Sofia B. Ahmed, Jill B. Becker, Katelyn A. Bruno, Sandra M. Dumanski, Liisa A. M. Galea, Marija Kundakovic, Armin Raznahan, Natalie C. Tronson, Rebecca L. Cunningham   +8 more
doaj   +1 more source

Carcinomas and Carcinoid Tumors of the Lungs and Bronchi in Children and Adolescents: The EXPeRT Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary lung carcinomas and bronchial carcinoid tumors (BC) are very rare malignancies in childhood. While typical BC and mucoepidermoid carcinomas are mostly low‐grade, localized tumors with a more favorable prognosis than in adults, necessitating avoidance of overtreatment, adenocarcinomas of the lung are often diagnosed at advanced disease ...
Michael Abele, Calogero Virgone, Michaela Kuhlen, Sabine Irtan, Yves Reguerre, Malgorzata Krawczyk, Ewa Bien, Tal Ben‐Ami, Maja Cesen, Ricardo Lopez‐Almaraz, Andrea Ferrari, Gianni Bisogno, Dominik T. Schneider, Abbas Agaimy, Constantin Lapa, Hubert Ducou le Pointe, Rainer Claus, Catherine Daniel, Ines B. Brecht, Daniel Orbach   +19 more
wiley   +1 more source

Sex differences in the medial prefrontal cortical glutamate system

, 2022
Background: Dysregulation in the prefrontal cortex underlies a variety of psychiatric illnesses, including substance use disorder, depression, and anxiety.
Rich, Matthew T., Briand, Lisa, Deutschmann|, Zallar, Lia J., McGrath, Anna G., Briand|, Knouse|, Knouse, Melissa, Rajadhyaksha, Anjali M., Deutschmann, Andre   +9 more
core   +1 more source

Advancing evidence-based regulation: Organization for the Study of Sex Differences and Society for Women’s Health Research support FDA action on menopausal hormone therapy and encourage broader sex-informed drug label updates

Biology of Sex Differences
Menopause is an important life-stage transition with substantial implications for health and quality of life. Menopausal hormone therapy (HT) remains among the most effective treatments for menopausal symptoms, yet clinical uptake has varied markedly ...
Rebecca L. Cunningham, Liisa A.M. Galea, Syreen Goulmamine, Georgios Kararigas, Kathryn G. Schubert, Kristen L. Zuloaga, Sofia B. Ahmed   +6 more
doaj   +1 more source

Roles for androgens in mediating the sex differences of neuroendocrine and behavioral stress responses

Biology of Sex Differences, 2020
Estradiol and testosterone are powerful steroid hormones that impact brain function in numerous ways. During development, these hormones can act to program the adult brain in a male or female direction.
Damian G. Zuloaga, Ashley L. Heck, Rose M. De Guzman, Robert J. Handa   +3 more
doaj   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Sex differences in adenosine deaminase activity associate with disparities in SARS-CoV-2 innate immunity

iScience
Summary: Females demonstrate elevated type-I interferon production and a stronger antiviral immune response; however, the mechanisms underlying sex-based differences in antiviral immunity are incompletely understood.
Priyanka Saminathan, Ian T. Mathews, Ahmad Alimadadi, Kai Fung, Kiyokazu Kakugawa, Leo A.B. Joosten, Mihai G. Netea, Mohit Jain, Susan Cheng, Catherine C. Hedrick, Sonia Sharma   +10 more
doaj   +1 more source

Turning sex inside-out: Peripheral contributions to sexual differentiation of the central nervous system

Biology of Sex Differences, 2012
Sexual differentiation of the nervous system occurs via the interplay of genetics, endocrinology and social experience through development. Much of the research into mechanisms of sexual differentiation has been driven by an implicit theoretical ...
Swift-Gallant Ashlyn, Niel Lee, Monks D
doaj   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source