Results 271 to 280 of about 4,262,907 (402)

Gender identity and mental health inequalities 2001-2022: population-level evidence from an Australian cohort study. [PDF]

open access: yesBMJ Ment Health
Saxby K   +6 more
europepmc   +1 more source

NAT10 Increases Lysosomal Acidification to Promote Esophageal Cancer Metastasis via ac4C Acetylation of ATP6V0E1 mRNA

open access: yesAdvanced Science, EarlyView.
Zhan et al. demonstrate the vital role of NAT10‐catalyzed ac4C modification in regulating autophagy‐associated lysosomal acidification. They uncover the clinical and biological significance of ATP6V0E1, an important v‐ATPase assembly subunit, in tumor metastasis, particularly in the malignant progression of ESCC.
Yu‐Juan Zhan   +23 more
wiley   +1 more source

LIMK1 as a Novel Kinase of β‐Catenin Promotes Esophageal Cancer Metastasis by Cooperating With CDK5

open access: yesAdvanced Science, EarlyView.
Li et al. innovatively map the kinase‐substrate network in esophageal cancer metastasis. Their study demonstrates that LIM domain kinase 1 (LIMK1) and Cyclin‐dependent kinase 5 (CDK5) synergistically increase the phosphorylation of β‐catenin, thereby activating the Wnt/β‐catenin signaling pathway to promote esophageal cancer metastasis.
Shu‐Jun Li   +27 more
wiley   +1 more source

AI‐Driven Defecation Analysis by Smart Healthcare Toilet: Exploring Biometric Patterns and Eu‐Tenesmus

open access: yesAdvanced Science, EarlyView.
A healthcare toilet system is introduced to passively measure defecation behavior. Real‐time data on stool dropping duration, thickness, and a newly defined “eu‐tenesmus” interval show correlations with stool form and gender differences. Results from 45 defecation events reveal a promising method for comprehensive defecation analysis.
Zhiquan Song   +16 more
wiley   +1 more source

A Human Immuno‐Lung Organoid Model to Study Macrophage‐Mediated Lung Cell Senescence Upon SARS‐CoV‐2 Infection

open access: yesAdvanced Science, EarlyView.
Immuno‐lung organoids are developed and used spatial transcriptomics to uncover how proinflammatory macrophages drive lung cell senescence via the THBS1–(ITGA3+ITGB1) axis in COVID‐19. To ensure broad accessibility, LungSpatialDB is created, an AI‐powered data portal, enabling intuitive exploration of spatial data and biological insights through ...
Yuling Han   +24 more
wiley   +1 more source

Research priorities for gender nonconforming/transgender youth: gender identity development and biopsychosocial outcomes

open access: yesCurrent Opinion in Endocrinology, Diabetes & Obesity, 2016
Johanna Olson-Kennedy   +6 more
semanticscholar   +1 more source

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