Results 41 to 50 of about 2,490,455 (287)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Collaborating for Gender Equity in Christian Education

open access: yes, 2020
This essay addresses the importance of teachers promoting gender equity. It explores potential causes for gender discrimination in Christian institutions including double standards, unequal representation, organizational culture and similarity attraction.
Castellon, Adrienne R., Sowerby, Stacy
core  

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Public Priorities: Deficit Rising, Terrorism Slipping [PDF]

open access: yes, 2012
Presents - by age, gender, political affiliation, and income - survey findings about Americans' priorities with respect to domestic and foreign policy issues as well as economic, fiscal, social, national security, and environmental ...

core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Developing an index for measuring gender lens investing in organizations: the GLIMETRICS framework

open access: yesFrontiers in Psychology
IntroductionThe objective of this article is to develop and validate a metric for assessing gender lens investing (GLI) practices within organizations. The validation of these measurement items constitutes a methodological innovation, responding to calls
Maite Palomo-Vadillo   +3 more
doaj   +1 more source

SOCIO-CULTURAL AND PHILOSOPHICAL-LEGAL DIMENSIONS OF THE GENDER IDENTITY PROBLEM

open access: yesAntropologìčnì Vimìri Fìlosofsʹkih Doslìdžen', 2019
Purpose. Based on the comparative analysis of the European and post-Soviet countries, the purpose of the article is to study one of the manifestations of gender discrimination, namely the problem of gender equality in the sphere of labor. It involves the
V. S. Blikhar   +2 more
doaj   +1 more source

Sustainable Mobility Issues of Physically Active University Students: The Case of Serres, Greece

open access: yesFuture Transportation, 2021
The mobility practices of students are largely dictated by their respective educational obligations. Students of physical education are an ostensibly physically active population, whose active lifestyle may include active travel.
Foteini Mikiki   +2 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Chamanisme féminin « contre nature » ? Menstruation, gestation et femmes chamanes parmi les Shipibo-Conibo de l’Amazonie occidentale

open access: yesJournal de la Société des Américanistes, 2006
« Counter-natural » female shamanism? Menstruation, gestation and female shamans among the Shipibo-Conibo of Western Amazonia. Amazonian shamanism is often described as a male social role from which women are ‘naturally’ excluded because of taboos ...
Anne-Marie Colpron
doaj   +1 more source

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