Results 221 to 230 of about 1,959,870 (301)

The hidden cost of fitting in: social camouflage in adolescents with social communication disorder. [PDF]

Front Psychol
Azizpour A, Hemati Alamdarloo G, Shojaei S, Moradi S.   +3 more
europepmc   +1 more source

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source

Identifying Themes in the Knowledge and Attitudes of UK Healthcare Professionals Towards Transgender and Nonbinary Patients: An Evidence Review. [PDF]

Clin Teach
Martin A, Preston L.
europepmc   +1 more source

Trophic Diversity in Duckweed: Mixotrophy, More Than the Sum of its Extremes

Advanced Science, EarlyView.
In the context of rising DOC in aquatic environments, mixotrophic duckweed may impact carbon cycling by acting as either a carbon sink, as they absorb CO2 through photosynthesis, or a carbon source, as they release CO2 through respiration of absorbed DOC, which depends on DOC concentration, light availability, temperature, and other environmental ...
Zuoliang Sun, Yan Chen, Fajun Li, Xuyao Zhao, Qingxiang Han, Hongwei Hou   +5 more
wiley   +1 more source

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

The effect of gender role stress on psychological distress in women with breast cancer after mastectomy. [PDF]

Support Care Cancer
Yılmaz S, Açıkgöz S, Erdem OÇ.
europepmc   +1 more source

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

Data gaps for symptoms of myocardial infarction in transgender and gender diverse patients: a brief literature review and call to action. [PDF]

Front Public Health
Schoenike D, Yoakum CB, Peterson JL.
europepmc   +1 more source

NFYB Integrates Hormonal Signals into Tissue Allometry by Promoting Protein Biosynthesis

Advanced Science, EarlyView.
In the American cockroach, NFYB acts as a spatiotemporin that translates distinct hormonal cues into tissue‐specific allometry. Juvenile hormone activates NFYB in the early fat body, while 20‐hydroxyecdysone induces it in late wing pads. NFYB then promotes protein biosynthesis via core translational machinery, driving differential growth across the ...
Fangfang Liu, Shiming Zhu, Sishi Xia, Xiaoshuai Zhang, Qin Li, Zhanquan Zeng, Yuqing Liu, Wanyin Liang, Guanyu Zhou, Erxia Du, Suning Liu, Sheng Li   +11 more
wiley   +1 more source