Results 61 to 70 of about 2,188,158 (345)

The influence of ROS1 fusion partners and resistance mechanisms in ROS1‐TKI‐treated non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the
Fenneke Zwierenga, Christa Dijkhuizen, Patrick Korthuis, Wim Timens, Harry Groen, Jeroen Hiltermann, Anke van den Berg, Lyndsay Drayer, Anthonie van der Wekken   +8 more
wiley   +1 more source

Healthcare for migrant workers in destination countries: a comparative qualitative study of China and Malaysia

BMJ Open, 2020
Objectives This paper explores policies addressing migrant worker’s health and barriers to healthcare access in two middle-income, destination countries in Asia with cross-border migration to Yunnan province, China and international migration to Malaysia.
Tharani Loganathan, Deng Rui, Nicola Suyin Pocock   +2 more
doaj   +1 more source

Stigma Experienced by Transgender Women of Color in Their Dating and Romantic Relationships: Implications for Gender-based Violence Prevention Programs

Journal of Interpersonal Violence, 2020
Although transgender women of color, specifically Black and Latina experience gender-based violence in a variety of contexts, one of the most consistently reported is from a dating or romantic partner.
K. Gamarel, Laura Jadwin-Cakmak, Wesley M. King, A. Lacombe-Duncan, Racquelle Trammell, Lilianna A Reyes, Cierra Burks, Bré Rivera, Emily A. Arnold, G. Harper   +9 more
semanticscholar   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

The ethics of knowledge sharing: a feminist examination of intellectual property rights and open-source materials in gender transformative methodologies

Frontiers in Research Metrics and Analytics
Debates on intellectual property rights and open source frequently stem from the business sector and higher education, where goals are typically oriented toward profit, academic status, credit, and/or reputation.
Leah Goldmann, Alice Welbourn, Diane Gillespie, Nastnet Ghebrebhran, Lufuno Barro, Sara Siebert, Hawa Kagoya, Lori Michau, Anjalee Kohli, Tina Musuya, Sonia Rebecca Kusiima   +10 more
doaj   +1 more source

Reconstruction of Autobiographical Memories of Violent Sexual-Affective Relationships Through Scientific Reading on Love: A Psycho-Educational Intervention to Prevent Gender Violence

Frontiers in Psychology, 2018
Violence in sexual-affective relationships among teens and young people is recognized as a social, educational, and health problem that has increased worldwide in recent years.
Sandra Racionero-Plaza, Leire Ugalde-Lujambio, Lídia Puigvert, Emilia Aiello   +3 more
semanticscholar   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

From Gender Regimes to Violence Regimes: Re-thinking the Position of Violence

Social Politics: International Studies in Gender, State and Society, 2020
:What happens when we focus primarily on violence as a central question—either within the gender regime approach or by making violence regime an approach in itself?
J. Hearn, Sofia Strid, A. Humbert, Dag Balkmar, Marine Delaunay   +4 more
semanticscholar   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Using Social Media to Recruit Seldom-Heard Groups: Reaching Women and Girls with Experience of Violence in Iran

Social Sciences
Social media recruitment and online surveys are valuable tools in social science research, but their effectiveness in reaching seldom-heard victims of gender violence in low-middle income (LMI) countries is under-explored.
Ladan Hashemi, Fateme Babakhani, Nadia Aghtaie, Sally McManus   +3 more
doaj   +1 more source