Results 111 to 120 of about 1,093,414 (290)

An epidemiologic approach to gene‐environment interaction [PDF]

, 1990
Ruth Ottman, D. C. Rao
openalex   +1 more source

Expanding the modern synthesis II: Formal perspectives on the inherent role of niche construction in fitness [PDF]

, 2010
Expanding the modern synthesis requires elevating the role of interaction within and across various biological scales to the status of an evolutionary principle.
Rodrick Wallace
core   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Differential Misclassification and the Assessment of Gene-Environment Interactions in Case-Control Studies [PDF]

, 1998
Montserrat García‐Closas, W. Douglas Thompson, James M. Robins   +2 more
openalex   +1 more source

A biomarker based on gene expression indicates plant water status in controlled and natural environments

, 2013
Plant or soil water status are required in many scientific fields to understand plant responses to drought. Because the transcriptomic response to abiotic conditions, such as water deficit, reflects plant water status, genomic tools could be used to ...
Blanchet, Nicolas, Boniface, Marie-Claude, Burger, Philippe, Casadebaig, Pierre, Debaeke, Philippe, Langlade, Nicolas B., Marchand, Gwenaëlle, Maury, Pierre, Mayjonade, Baptiste, Nambinina, Fety Andrianasolo, Varès, Didier, Vincourt, Patrick   +11 more
core   +2 more sources

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

Gene-environment interaction in hereditary nonpolyposis colorectal cancer with implications for diagnosis and genetic testing [PDF]

, 1999
Jae-Gahb Park, Young Jin Park, Juul Wijnen, Hans F. A. Vasen   +3 more
openalex   +1 more source

An agent-based simulation framework for complex systems [PDF]

, 2012
In this abstract we present a new approach to the simulation of complex systems as biological interaction networks, chemical reactions, ecosystems, etc.
Benso, Alfredo, Di Carlo, Stefano, Politano, Gianfranco Michele Maria, Savino, Alessandro, Ur Rehman, Hafeez   +4 more
core  

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source