Gene-environment interaction in the pathophysiology of type 1 diabetes [PDF]
Frontiers in EndocrinologyType 1 diabetes (T1D) is a complex metabolic autoimmune disorder that affects millions of individuals worldwide and often leads to significant comorbidities.
Rahul Mittal +4 more
doaj +3 more sources
Gene-environment interaction in molar-incisor hypomineralization.
PLoS ONE, 2021 Molar incisor hypomineralization (MIH) is an enamel condition characterized by lesions ranging in color from white to brown which present rapid caries progression, and mainly affects permanent first molars and incisors. These enamel defects usually occur
Mariana Bezamat +22 more
doaj +2 more sources
Many roads to a gene-environment interaction. [PDF]
Am J Hum GenetDespite the importance of gene-environment interactions (GxEs) in improving and operationalizing genetic discovery, interpretation of any GxEs that are discovered can be surprisingly difficult.
Westerman KE, Sofer T.
europepmc +2 more sources
Gene-environment interaction in functional hypothalamic amenorrhea [PDF]
Frontiers in EndocrinologyFunctional hypothalamic amenorrhea (FHA) is a common cause of amenorrhea and chronic anovulation in adolescent girls and young women, diagnosed after excluding other organic causes.
Federica Barbagallo +11 more
doaj +2 more sources
Gene-Environment Interaction Loci Associated with Refractive Error: SCAMPI Analysis [PDF]
Ophthalmology SciencePurpose: To compare the performance of a novel method for identifying candidate gene-environment interaction loci, Scalable Cauchy Aggregate test using Multiple Phenotypes to test Interactions (SCAMPI) (doi:10.1101/2024.09.10.612314v1), to widely used ...
Xi He, MSc, MD +82 more
doaj +2 more sources
Genetic susceptibility shaped by biological state: beyond gene-environment interaction [PDF]
Frontiers in GeneticsThis mini-review proposes a state-aware approach for interpreting gene-environment interaction (G × E). Biological state is the internal condition in which genetic susceptibility becomes functional. A measured exposure may precede that state, reflect it,
Hui-Qi Qu +5 more
doaj +2 more sources
Genotype by environment interaction for gene expression in Drosophila melanogaster
Nature Communications, 2020 Huang et al. show that developing under different temperatures changes the genetic architecture of regulatory variation in Drosophila melanogaster gene expression yet the co-expression network remains robust.
Wen Huang +4 more
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Exploring the influence of the DRD2 gene on mathematical ability: perspectives of gene association and gene-environment interaction [PDF]
BMC PsychologyMathematical ability is influenced by genes and environment. This study focused on the effect of DRD2, a candidate gene for working memory, on mathematical ability.
Qing Yang +4 more
doaj +2 more sources
Gene-environment interaction analysis of school quality and educational inequality [PDF]
npj Science of LearningWe study to what extent schools increase or decrease environmental and genetic influences on educational performance. Building on behavioral genetics literature on gene-environment interactions and sociological literature on the compensating and ...
Kim Stienstra +2 more
doaj +2 more sources
Gene-Environment Interaction: A Variable Selection Perspective. [PDF]
Methods in molecular biology, 2020 Gene-environment interactions have important implications for elucidating the genetic basis of complex diseases beyond the joint function of multiple genetic factors and their interactions (or epistasis).
Fei Zhou +4 more
semanticscholar +1 more source