Results 41 to 50 of about 922,149 (303)

Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function [PDF]

open access: yes, 2012
Genome-wide association studies have identified numerous genetic loci for spirometic measures of pulmonary function, forced expiratory volume in one second (FEV1), and its ratio to forced vital capacity (FEV1/FVC).
Wenbo Tang (110161)   +678 more
core   +1 more source

The lipoprotein lipase S447X polymorphism and plasma lipids

open access: yesJournal of Lipid Research, 2004
We studied 4,058 subjects from a representative sample of the Singapore population 1) to determine the association between the S447X polymorphism at the LPL locus and serum lipid concentration in Chinese, Malays, and Asian Indians living in Singapore and
J. Lee   +6 more
doaj   +1 more source

Gene-Gene Interaction between APOA5 and USF1: Two Candidate Genes for the Metabolic Syndrome [PDF]

open access: yes, 2009
Objective: The metabolic syndrome, a major cluster of risk factors for cardiovascular diseases, shows increasing prevalence worldwide. Several studies have established associations of both apolipoprotein A5 (APOA5) gene variants and upstream stimulatory ...
Wichmann, Heinz-Erich   +21 more
core   +1 more source

IPRS: Leveraging Gene-Environment Interaction to Reconstruct Polygenic Risk Score

open access: yesFrontiers in Genetics, 2022
Background: Polygenic risk score (PRS) is widely regarded as a predictor of genetic susceptibility to disease, applied to individuals to predict the risk of disease occurrence.
Yingdan Tang   +6 more
doaj   +1 more source

Gene-environment interactions in atherosclerosis

open access: yesMolecular and Cellular Biochemistry, 1992
It is becoming clear that genetic and environmental factors can interact to varying degrees in a given individual. In some cases, genetically determined resistance to CAD (eg, genetic hyperalpha- or hypobetalipoproteinemia), or genetically determined susceptibility to CAD (eg, high Lp[a] levels) may not be significantly modulated by a prudent lifestyle.
openaire   +4 more sources

Use of spermatozoal mRNA profiles to study gene-environment interactions in human germ cells

open access: yes, 2009
Paternal exposure to genotoxic compounds is thought to contribute to diseases in their offspring. Therefore, it is of importance to develop biomarkers of male germ cell exposure to genotoxins.
Cemeli, E.   +6 more
core   +1 more source

Gene-environment interactions and the response to exercise

open access: yesInternational Journal of Experimental Pathology, 2000
Many of the symptoms of heart failure (breathlessness and fatigue) are not primarily due to reduced cardiac output, but relate to an impairment of peripheral muscle performance and metabolic efficiency. With regular training it is possible to increase skeletal muscle performance through improvements in muscle efficiency.
H, Montgomery, D, Brull
openaire   +3 more sources

Gene-Environment Interactions in Stress Response Contribute Additively to a Genotype-Environment Interaction.

open access: yesPLoS Genetics, 2016
How combinations of gene-environment interactions collectively give rise to genotype-environment interactions is not fully understood. To shed light on this problem, we genetically dissected an environment-specific poor growth phenotype in a cross of two
Takeshi Matsui, Ian M Ehrenreich
doaj   +1 more source

Gene-environment interaction models identified by the GMDR method with adjustment for age and gender.

open access: yes, 2017
Gene-environment interaction models identified by the GMDR method with adjustment for age and gender.
Chung-Feng Kao (104445)   +5 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

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