Results 21 to 30 of about 11,702,420 (293)

Gene–Environment Interactions for Parkinson's Disease

Annals of Neurology, 2023
Objective Parkinson's disease (PD) is a neurodegenerative disorder with complex etiology. Multiple genetic and environmental factors have been associated with PD, but most PD risk remains unexplained. The aim of this study was to test for statistical interactions between PD‐related genetic and environmental ...
Alexandra Reynoso, Roberta Torricelli, Benjamin Meir Jacobs, Jingchunzi Shi, Stella Aslibekyan, Lucy Norcliffe‐Kaufmann, Alastair J Noyce, Karl Heilbron   +7 more
openaire   +3 more sources

A novel approach to simulate gene-environment interactions in complex diseases [PDF]

, 2010
Background: Complex diseases are multifactorial traits caused by both genetic and environmental factors. They represent the major part of human diseases and include those with largest prevalence and mortality (cancer, heart disease, obesity, etc ...
Amato, Roberto, G. Raiconi, ROBERTO AMATO, Miele, Gennaro, Nicodemi Mario, D. D'Andrea, Amato Roberto, AND SERGIO COCOZZA, MARIO NICODEMI, MICHELE PINELLI, Nicodemi, Mario, D'Andrea Daniel, Pinelli, Michele, Sergio Cocozza, Raiconi, Giancarlo, GENNARO MIELE, Amato, R. (Roberto), Cocozza Sergio, Raiconi Giancarlo, Miele Gennaro, Giancarlo Raiconi, D’Andrea, Daniel, Cocozza, Sergio, Pinelli Michele, DANIEL D'ANDREA, D'Andrea, Daniel   +25 more
core   +1 more source

Simulating gene-gene and gene-environment interactions in complex diseases: Gene-Environment iNteraction Simulator 2

BMC Bioinformatics, 2012
Background The analysis of complex diseases is an important problem in human genetics. Because multifactoriality is expected to play a pivotal role, many studies are currently focused on collecting information on the genetic and environmental factors ...
Pinelli Michele, Scala Giovanni, Amato Roberto, Cocozza Sergio, Miele Gennaro   +4 more
doaj   +1 more source

Regulation of Pancreatic β-Cell Mass by Gene-Environment Interaction [PDF]

Diabetes & Metabolism Journal, 2022
The main pathogenic mechanism of diabetes consists of an increase in insulin resistance and a decrease in insulin secretion from pancreatic β-cells. The number of diabetic patients has been increasing dramatically worldwide, especially in Asian people ...
Shun-ichiro Asahara, Hiroyuki Inoue, Yoshiaki Kido   +2 more
doaj   +1 more source

Boosting for detection of gene–environment interactions [PDF]

Statistics in Medicine, 2012
In genetic association studies, it is typically thought that genetic variants and environmental variables jointly will explain more of the inheritance of a phenotype than either of these two components separately. Traditional methods to identify gene–environment interactions typically consider only one measured environmental variable at a time. However,
Pashova, H., LeBlanc, M., Kooperberg, C.
openaire   +2 more sources

Knockout of the Bcmo1 gene results in an inflammatory response in female lung, which is suppressed by dietary beta-carotene [PDF]

, 2010
Beta-carotene 15,15'-monooxygenase 1 knockout (Bcmo1 (-/-)) mice accumulate beta-carotene (BC) similarly to humans, whereas wild-type (Bcmo1 (+/+)) mice efficiently cleave BC.
Yvonne G. J. van Helden, Georg Lietz, Roger W. L. Godschalk, Jaap Keijer, Teerds, K., Hessel, S., Keijer, J., Schooten, F.J., van, Adrian Wyss, von Lintig, J., Sandra G. Heil, Heil, S.G., Kramer, E., Lietz, G., van Schooten, F.J., Lintig, J., von, Amengual, J., Wyss, A., Ribot, J., Katja Teerds, Frederik J. van Schooten, Helden, Y.G.J., Johannes von Lintig, Godschalk, R.W.L., M. Luisa Bonet, van Helden, Y.G., Evelien Kramer, Joan Ribot, Susanne Hessel, Teerds, K.J., Bonet, M.L., Jaume Amengual   +31 more
core   +1 more source

A flexible Bayesian model for studying gene-environment interaction. [PDF]

PLoS Genetics, 2012
An important follow-up step after genetic markers are found to be associated with a disease outcome is a more detailed analysis investigating how the implicated gene or chromosomal region and an established environment risk factor interact to influence ...
Kai Yu, Sholom Wacholder, William Wheeler, Zhaoming Wang, Neil Caporaso, Maria Teresa Landi, Faming Liang   +6 more
doaj   +1 more source

Gene-environment interaction between body mass index and transforming growth factor beta 1 (TGFβ1) gene in knee and hip osteoarthritis [PDF]

, 2013
Introduction: The objective was to investigate potential gene-environment interaction between body mass index (BMI) and each of eight TGFβ1 polymorphisms in knee and hip osteoarthritis (OA).
Muthuri, Stella G., Sally Doherty, Weiya Zhang, Zhang, W, Rose A Maciewicz, Maciewicz, Rose A., Muir, Kenneth, Doherty, M, Doherty, S, Muir, K; id_orcid, Stella G Muthuri, Muir, Kenneth R., Doherty, Sally A., Muthuri, S G, Doherty, Sally, Maciewicz, R A, Kenneth R Muir, Michael Doherty, Zhang, Weiya, Doherty, Michael   +19 more
core   +1 more source

Interactions between Polygenic Scores and Environments: Methodological and Conceptual Challenges

Sociological Science, 2020
Interest in the study of gene–environment interaction has recently grown due to the sudden availability of molecular genetic data—in particular, polygenic scores—in many long-running longitudinal studies.
Benjamin W. Domingue, Sam Trejo, Emma Armstrong-Carter, Elliot M. Tucker-Drob   +3 more
doaj   +1 more source

Myopia: Gene-environment Interaction

Annals of the Academy of Medicine Singapore, 2000
Introduction: Myopia has reached epidemic proportions in Japan, Hong Kong, Taiwan and Singapore. This review summarises the evidence for environmental and genetic factors as well as gene-environment interaction for myopia for both epidemiologic studies as well as animal models.
Yap, E., Saw, S.M., Chua, W.H., Wu, H.M., Chia, K.S., Stone, R.A.   +5 more
openaire   +2 more sources