Results 21 to 30 of about 15,130,803 (334)
Gene–environment interactions in asthma [PDF]
Occupational and Environmental Medicine, 2006 Asthma is a complex disease with a diverse genetic and environmental component.1 Asthma shows a high level of phenotypic heterogeneity characterised by obstruction of the airways of the lung and is related with atopy, bronchial hyperresponsiveness (BHR), and increased IgE levels.
F, Castro-Giner +3 more
openaire +2 more sources
GEM: scalable and flexible gene–environment interaction analysis in millions of samples
bioRxiv, 2020 Gene-environment interaction (GEI) studies are a general framework that can be used to identify genetic variants that modify environmental, physiological, lifestyle, or treatment effects, as well as those contributing to age, sex, racial or ethnic ...
K. Westerman +9 more
semanticscholar +1 more source
Gene environment interactions in asthma [PDF]
Archives of Disease in Childhood, 2007 The underlying pathogenesis of asthma, one of the most common chronic diseases of childhood, is not fully understood. There is a well-documented heritable component to this disease and environmental factors associated with a Westernised lifestyle have also been implicated; recent studies suggest gene-environment interactions are important in the ...
S, McLeish, S W, Turner
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How ambient temperature affects the heading date of foxtail millet (Setaria italica)
Frontiers in Plant Science, 2023 Foxtail millet (Setaria italica), a short-day plant, is one of the important crops for food security encountering climate change, particularly in regions where it is a staple food.
Ya-Chen Huang +8 more
doaj +1 more source
Efficient gene–environment interaction testing through bootstrap aggregating
Scientific Reports, 2023 Gene–environment (GxE) interactions are an important and sophisticated component in the manifestation of complex phenotypes. Simple univariate tests lack statistical power due to the need for multiple testing adjustment and not incorporating potential ...
Michael Lau +3 more
doaj +1 more source
Signatures of adaptation in myopia-related genes on the sunlight exposure hypothesis
Journal of Physiological Anthropology, 2023 Background Myopia is a common eye disorder that results from gene-environment interactions. The prevalence of myopia varies across populations, and exposure to bright sunlight may prevent its development.
Tian Xia, Kazuhiro Nakayama
doaj +1 more source
BMC Bioinformatics, 2012 Background The analysis of complex diseases is an important problem in human genetics. Because multifactoriality is expected to play a pivotal role, many studies are currently focused on collecting information on the genetic and environmental factors ...
Pinelli Michele +4 more
doaj +1 more source
Gene–Environment Interactions for Parkinson's Disease
Annals of Neurology, 2023 Objective Parkinson's disease (PD) is a neurodegenerative disorder with complex etiology. Multiple genetic and environmental factors have been associated with PD, but most PD risk remains unexplained. The aim of this study was to test for statistical interactions between PD‐related genetic and environmental ...
Alexandra Reynoso +7 more
openaire +3 more sources
Boosting for detection of gene–environment interactions [PDF]
Statistics in Medicine, 2012 In genetic association studies, it is typically thought that genetic variants and environmental variables jointly will explain more of the inheritance of a phenotype than either of these two components separately. Traditional methods to identify gene–environment interactions typically consider only one measured environmental variable at a time. However,
Pashova, H., LeBlanc, M., Kooperberg, C.
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Interactions between Polygenic Scores and Environments: Methodological and Conceptual Challenges
Sociological Science, 2020 Interest in the study of gene–environment interaction has recently grown due to the sudden availability of molecular genetic data—in particular, polygenic scores—in many long-running longitudinal studies.
Benjamin W. Domingue +3 more
doaj +1 more source