Results 31 to 40 of about 11,702,420 (293)

Artificial neural networks modeling gene-environment interaction

BMC Genetics, 2012
Background Gene-environment interactions play an important role in the etiological pathway of complex diseases. An appropriate statistical method for handling a wide variety of complex situations involving interactions between variables is still lacking,
Günther Frauke, Pigeot Iris, Bammann Karin   +2 more
doaj   +1 more source

Gene-Environment Interaction in Childhood Asthma [PDF]

International Journal of Immunopathology and Pharmacology, 2011
The importance of early life environmental influences on the etiology of asthma is implied by the observed geographic and temporal variation in the prevalence of the disease among children. There is evidence pointing to the role of exposure to allergen, various aspects of diet and hygiene-related factors in the etiology of asthma.
RIGOLI, Luciana Concetta, BRIUGLIA, Silvana, Caimmi S, Ferraú V, GALLIZZI, Romina, Leonardi S, La Rosa M, SALPIETRO DAMIANO, Carmelo   +7 more
openaire   +3 more sources

Candidate gene-environment interactions in substance abuse: A systematic review.

PLoS ONE, 2023
BackgroundThe abuse of psychogenic drugs can lead to multiple health-related problems. Genetic and environmental vulnerabilities are factors in the emergence of substance use disorders.
Zheng Jiang, Zidong Chen, Xi Chen
doaj   +1 more source

Structured gene‐environment interaction analysis [PDF]

Biometrics, 2019
AbstractFor the etiology, progression, and treatment of complex diseases, gene‐environment (G‐E) interactions have important implications beyond the main G and E effects. G‐E interaction analysis can be more challenging with higher dimensionality and need for accommodating the “main effects, interactions” hierarchy.
Mengyun Wu, Qingzhao Zhang, Shuangge Ma
openaire   +4 more sources

Dependent negative life events and sleep quality: An examination of gene-environment interplay. [PDF]

, 2011
Objectives: Negative life events are associated with sleep disturbances. Further understanding of these associations is beneficial as sleep disturbances are common.
Eley, Thalia C., Rijsdijk, Frühling, Thalia C. Eley, Gregory, Alice M., Nicola L. Barclay, Barclay, Nicola L., Rijsdijk, Fruhling V., Gregory, Alice, Fruhling V. Rijsdijk, Barclay, Nicola, Eley, Thalia, Alice M. Gregory   +11 more
core   +1 more source

Finding gene-environment interactions for phobias [PDF]

European Archives of Psychiatry and Clinical Neuroscience, 2008
Phobias are common disorders causing a great deal of suffering. Studies of gene-environment interaction (G x E) have revealed much about the complex processes underlying the development of various psychiatric disorders but have told us little about phobias.
Gregory, Alice M, Lau, Jennifer Y F, Eley, Thalia C   +2 more
openaire   +4 more sources

Genetic interactions affecting human gene expression identified by variance association mapping

eLife, 2014
Non-additive interaction between genetic variants, or epistasis, is a possible explanation for the gap between heritability of complex traits and the variation explained by identified genetic loci.
Andrew Anand Brown, Alfonso Buil, Ana Viñuela, Tuuli Lappalainen, Hou-Feng Zheng, J Brent Richards, Kerrin S Small, Timothy D Spector, Emmanouil T Dermitzakis, Richard Durbin   +9 more
doaj   +1 more source

Gene–Environment Interactions on Growth Trajectories [PDF]

Genetic Epidemiology, 2012
It has been suggested that children with larger brains tend to perform better on IQ tests or cognitive function tests. Prenatal head growth and head growth in infancy are two crucial periods for subsequent intelligence. Studies have shown that environmental exposure to air pollutants during pregnancy is associated with fetal growth reduction ...
Wang, Shuang, Xiong, Wei, Ma, Weiping, Chanock, Stephen, Jedrychowski, Wieslaw, Wu, Rongling, Perera, Frederica P.   +6 more
openaire   +3 more sources

Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway [PDF]

, 2009
This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2009 Orton et al.BACKGROUND: The Epidermal Growth Factor Receptor (EGFR) activated Extracellular-signal Regulated Kinase (ERK) pathway is a critical cell ...
Gormand, A, Adriaens, M.E., Adriaens, Michiel E., Kolch, W, Amelie Gormand, Adriaens, ME, Gormand, A., Sturm, OE, David R Gilbert, Richard J Orton, Walter Kolch, Orton, RJ, Orton, Richard J., Oliver E Sturm, Gilbert, D, Gilbert, David R., Michiel Adriaens, M.E., Michiel E Adriaens, Orton, R.J., Kolch, Walter, Kolch, W., Gilbert, D.R., Sturm, O.E., Sturm, Oliver E., et al., Gormand, Amelie, Gormand, Amelie,, Lund University.   +27 more
core   +1 more source

Information-theoretic gene-gene and gene-environment interaction analysis of quantitative traits

BMC Genomics, 2009
Background The purpose of this research was to develop a novel information theoretic method and an efficient algorithm for analyzing the gene-gene (GGI) and gene-environmental interactions (GEI) associated with quantitative traits (QT).
Liu Song, Sucheston Lara, Chanda Pritam, Zhang Aidong, Ramanathan Murali   +4 more
doaj   +1 more source