Results 31 to 40 of about 15,130,803 (334)

Regulation of Pancreatic β-Cell Mass by Gene-Environment Interaction [PDF]

Diabetes & Metabolism Journal, 2022
The main pathogenic mechanism of diabetes consists of an increase in insulin resistance and a decrease in insulin secretion from pancreatic β-cells. The number of diabetic patients has been increasing dramatically worldwide, especially in Asian people ...
Shun-ichiro Asahara, Hiroyuki Inoue, Yoshiaki Kido   +2 more
doaj   +1 more source

Myopia: Gene-environment Interaction

Annals of the Academy of Medicine Singapore, 2000
Introduction: Myopia has reached epidemic proportions in Japan, Hong Kong, Taiwan and Singapore. This review summarises the evidence for environmental and genetic factors as well as gene-environment interaction for myopia for both epidemiologic studies as well as animal models.
Yap, E., Saw, S.M., Chua, W.H., Wu, H.M., Chia, K.S., Stone, R.A.   +5 more
openaire   +2 more sources

Candidate gene-environment interactions in substance abuse: A systematic review.

PLoS ONE, 2023
BackgroundThe abuse of psychogenic drugs can lead to multiple health-related problems. Genetic and environmental vulnerabilities are factors in the emergence of substance use disorders.
Zheng Jiang, Zidong Chen, Xi Chen
doaj   +1 more source

Gene-Environment Interaction in the Era of Precision Medicine

Cell, 2019
Innovative analytical frameworks are required to capture the complex gene-environment interactions. We investigate the insufficiency of commonly used models for disease genome analysis and suggest considering genetic interactions in complex diseases. For
Jing-Jing Li, Xiao Li, Sai Zhang, M. Snyder   +3 more
semanticscholar   +1 more source

Artificial neural networks modeling gene-environment interaction

BMC Genetics, 2012
Background Gene-environment interactions play an important role in the etiological pathway of complex diseases. An appropriate statistical method for handling a wide variety of complex situations involving interactions between variables is still lacking,
Günther Frauke, Pigeot Iris, Bammann Karin   +2 more
doaj   +1 more source

Gene-Environment Interaction in Childhood Asthma [PDF]

International Journal of Immunopathology and Pharmacology, 2011
The importance of early life environmental influences on the etiology of asthma is implied by the observed geographic and temporal variation in the prevalence of the disease among children. There is evidence pointing to the role of exposure to allergen, various aspects of diet and hygiene-related factors in the etiology of asthma.
RIGOLI, Luciana Concetta, BRIUGLIA, Silvana, Caimmi S, Ferraú V, GALLIZZI, Romina, Leonardi S, La Rosa M, SALPIETRO DAMIANO, Carmelo   +7 more
openaire   +3 more sources

Gene-environment interaction between body mass index and transforming growth factor beta 1 (TGFβ1) gene in knee and hip osteoarthritis [PDF]

, 2013
Introduction: The objective was to investigate potential gene-environment interaction between body mass index (BMI) and each of eight TGFβ1 polymorphisms in knee and hip osteoarthritis (OA).
Muthuri, Stella G., Sally Doherty, Weiya Zhang, Zhang, W, Rose A Maciewicz, Maciewicz, Rose A., Muir, Kenneth, Doherty, M, Doherty, S, Muir, K; id_orcid, Stella G Muthuri, Muir, Kenneth R., Doherty, Sally A., Muthuri, S G, Doherty, Sally, Maciewicz, R A, Kenneth R Muir, Michael Doherty, Zhang, Weiya, Doherty, Michael   +19 more
core   +1 more source

Finding gene-environment interactions for phobias [PDF]

European Archives of Psychiatry and Clinical Neuroscience, 2008
Phobias are common disorders causing a great deal of suffering. Studies of gene-environment interaction (G x E) have revealed much about the complex processes underlying the development of various psychiatric disorders but have told us little about phobias.
Gregory, Alice M, Lau, Jennifer Y F, Eley, Thalia C   +2 more
openaire   +4 more sources

Genetic interactions affecting human gene expression identified by variance association mapping

eLife, 2014
Non-additive interaction between genetic variants, or epistasis, is a possible explanation for the gap between heritability of complex traits and the variation explained by identified genetic loci.
Andrew Anand Brown, Alfonso Buil, Ana Viñuela, Tuuli Lappalainen, Hou-Feng Zheng, J Brent Richards, Kerrin S Small, Timothy D Spector, Emmanouil T Dermitzakis, Richard Durbin   +9 more
doaj   +1 more source

Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases.

American Journal of Epidemiology, 2017
Recently, many new approaches, study designs, and statistical and analytical methods have emerged for studying gene-environment interactions (G×Es) in large-scale studies of human populations.
K. McAllister, Leah E. Mechanic, C. Amos, H. Aschard, I. Blair, N. Chatterjee, D. Conti, W. Gauderman, L. Hsu, Carolyn M. Hutter, Marta M. Jankowska, J. Kerr, P. Kraft, S. Montgomery, B. Mukherjee, G. Papanicolaou, C. Patel, Marylyn D. Ritchie, B. Ritz, Duncan C. Thomas, P. Wei, J. Witte   +21 more
semanticscholar   +1 more source