Results 61 to 70 of about 15,130,803 (334)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Gene-gene interaction indifferent GC tissue samples.
, 2018 (a). Edges represents jointly contribute gene-gene interaction, illustrates TP73 gene-gene network upper show the first 25 genes that interact with TP73 gene. (b) down figure show four genes that interact with TP73.
Sana Akhtar Alvi (5745980) +8 more
core +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
IPRS: Leveraging Gene-Environment Interaction to Reconstruct Polygenic Risk Score
Frontiers in Genetics, 2022 Background: Polygenic risk score (PRS) is widely regarded as a predictor of genetic susceptibility to disease, applied to individuals to predict the risk of disease occurrence.
Yingdan Tang +6 more
doaj +1 more source
GENOME-WIDE GENE-ENVIRONMENT INTERACTION IN DEPRESSION: A SYSTEMATIC EVALUATION OF CANDIDATE GENES
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2017 Gene by environment (GxE) interaction studies have investigated the influence of a number of candidate genes and variants for major depressive disorder (MDD) on the association between childhood trauma and MDD. Most of these studies are hypothesis driven
Sandra Van der Auwera +25 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Minimum detectable hazard ratio for gene-environment interaction.
, 2016 Minimum detectable hazard ratio for gene-environment interaction.
Parminder Raina (2272063) +3 more
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Review of the Gene-Environment Interaction Literature in Cancer: What do we know?
Genetic Epidemiology, 2016 Risk of cancer is determined by a complex interplay of genetic and environmental factors. Although the study of gene‐environment interactions (G×E) has been an active area of research, little is reported about the known findings in the literature.
N. I. Simonds +6 more
semanticscholar +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source