Results 51 to 60 of about 8,668,830 (261)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

A realistic assessment of methods for extracting gene/protein interactions from free text [PDF]

, 2009
Background: The automated extraction of gene and/or protein interactions from the literature is one of the most important targets of biomedical text mining research.
Kabiljo, R., Clegg, AB, Renata Kabiljo, Shepherd, AJ, Kabiljo Renata, Clegg Andrew B, Andrew B Clegg, Shepherd Adrian J, Shepherd, Adrian J., Kabiljo, R, Clegg, A.B., Adrian J Shepherd   +11 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Gene-gene interaction network.

The identified miR target genes were analysed by means of a gene-gene interaction network using functional protein association networks software (String and Cytoscape software). The nodes in the networks are sized by their node degree. (TIF)
Marzia Rossato (3424763), Cristina Beltrami (2634700), Marco Tomasetti (293754), Federica Monaco (826196), Lory Santarelli (293775), Monica Amati (353759), Giacomo Sollini (17781413), Ernesto Pasquini (5754995), Massimo Re (5754986), Gaia Goteri (590527), Corrado Rubini (10527), Concetta De Quattro (17781410)   +11 more
core   +1 more source

Gene-environment interaction models identified by the GMDR method with adjustment for age and gender.

, 2017
Gene-environment interaction models identified by the GMDR method with adjustment for age and gender.
Chung-Feng Kao (104445), Po-Hsiu Kuo (104448), Yu-Li Liu (175348), Shih-Jen Tsai (160992), Albert C. Yang (222158), Eugene Lin (759907)   +5 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Gene-Drug Interaction in Stroke

Stroke Research and Treatment, 2011
Stroke is the third cause of mortality and one of most frequent causes of long-term neurological disability, as well as a complex disease that results from the interaction of environmental and genetic factors.
Serena Amici, Maurizio Paciaroni, Giancarlo Agnelli, Valeria Caso   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Gene-gene and gene-environment interactions of CYP19A1, ESR1, IL6, IL6R, IL1β, RANK, and RANKL variants in relation to osteoporosis and hip fracture risk in Mexican women

Frontiers in Aging
BackgroundOsteoporosis is a complex disease influenced by genetic variants, environmental factors, and comorbidities. While individual single-nucleotide variants (SNVs) have been associated with disease risk, limited data are available on how gene–gene ...
Antonio Miranda-Duarte, Valeria Ponce de León-Suárez, Alberto Hidalgo-Bravo, Rafael Velázquez-Cruz, Esperanza Ramírez-Pérez, O. Celeste Martínez-Ramírez, Clementina Castro-Hernández, Blanca Barredo-Prieto, Leonora Casas-Avila   +8 more
doaj   +1 more source