Results 281 to 290 of about 15,130,803 (334)

Gene-Environment Interaction and Cancer

2020
It is widely recognized that cancer is an epigenetic disease. Hypomethylation of cytosine residues of CpG dinucleotides, site-specific CpG promoter hypermethylation, altered histone methylation and acetylation and dysregulation of miRNAs have been shown in several types of cancers.
D'Esposito V., Ambrosio M. R., Perruolo G., Libutti M., Formisano P.   +4 more
openaire   +2 more sources

Gene-environment interactions in hypertension

Current Hypertension Reports, 1999
Environmental factors such as stress, diet, and physical activity have long been recognized as playing an important role in the pathogenesis of essential hypertension. Individuals may vary in their response to these factors depending on differences in genes determining physiologic systems that mediate the response.
Z, Pausova, J, Tremblay, P, Hamet
openaire   +2 more sources

Gene-environment interaction impacts on heart development and embryo survival

Development, 2019
Congenital heart disease (CHD) is the most common type of birth defect. In recent years, research has focussed on identifying the genetic causes of CHD. However, only a minority of CHD cases can be attributed to single gene mutations.
Julie L. M. Moreau, S. Kesteven, Ella M. M. A. Martin, Kin Lau, Michelle X. Yam, Victoria C. O'Reilly, G. del Monte-Nieto, A. Baldini, M. Feneley, A. Moon, R. Harvey, D. Sparrow, G. Chapman, S. Dunwoodie   +13 more
semanticscholar   +1 more source

Gene-Environment Interaction and Suicidal Behavior

Journal of Psychiatric Practice, 2009
Studies have increasingly shown that gene-environment interactions are important in psychiatry. Suicidal behavior is a major public health problem. Suicide is generally considered to be a multi-determined act involving various areas of proximal and distal risk.
ROY A, SARCHIAPONE, Marco, CARLI V.
openaire   +3 more sources

Gene-Environment Interactions in Obesity

2009
Obesity is a global and growing problem. The detrimental health consequences of obesity are significant and include co-morbidities such as diabetes, cancer and coronary heart disease. The marked rise in obesity observed over the last three decades suggests that behavioural and environmental factors underpin the chronic mismatch between energy intake ...
Marion M, Hetherington, Joanne E, Cecil
openaire   +2 more sources

Socioeconomic Deprivation Index Is Associated With Psychiatric Disorders: An Observational and Genome-wide Gene-by-Environment Interaction Analysis in the UK Biobank Cohort.

Biological Psychiatry, 2020
BACKGROUND Psychiatric disorders are among the largest and fastest-growing categories of the global disease burden. However, limited effort has been made to further elucidate associations between socioeconomic factors and psychiatric disorders from a ...
J. Ye, Y. Wen, Xi-Fang Sun, X. Chu, P. Li, B. Cheng, Shi-Qiang Cheng, L. Liu, Lu Zhang, Mei Ma, X. Qi, Chu-Jun Liang, O. Kafle, Yu-Meng Jia, C. Wu, S. Wang, X. Wang, Y. Ning, Shiquan Sun, F. Zhang   +19 more
semanticscholar   +1 more source

Gene–environment interactions in ocular diseases

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2009
Degenerative ocular diseases are widespread in the population and represent a major cause of reversible and irreversible blindness. Scientific evidences have been accumulating supporting the role of genotoxic damage and gene environment interactions in the pathogenesis of these diseases mainly including glaucoma, age-related macular degeneration, and ...
SACCA' SC, BOLOGNESI C, BATTISTELLA A, BAGNIS A, IZZOTTI, ALBERTO   +4 more
openaire   +3 more sources

Flavors in Gene–Environment Interactions

Epidemiology, 2007
In this issue, Noel Weiss (Epidemiology. 2007;18:429-430) presents the argument that gene-environment interaction should be approached through analysis of genetic effects within strata of environmental exposure, rather than the analysis of environmental effects within strata of genetic variants. Both approaches depend on a pair of 2-by-2 tables.
openaire   +2 more sources

Gene-environment interactions in asthma

Journal of Allergy and Clinical Immunology, 2009
Asthma is a complex disease, and its incidence is determined by an intricate interplay of genetic and environmental factors. The identification of novel genes for asthma suggests that many genes with small effects rather than few genes with strong effects contribute to the development of asthma.
openaire   +2 more sources

Gene-Environment Interactions in Pancreatic Cancer

Pancreatology, 2001
Exocrine pancreatic cancer remains a major cause of cancer death in Western populations. Despite many efforts, little is known about its etiology. Tobacco is the only established cause, although the proportion of cases of exocrine pancreatic cancer attributed to it is only 30%. A family history of pancreatic cancer accounts for 10% of the cases of this
openaire   +2 more sources