Results 251 to 260 of about 8,130,594 (350)

FGFR2 Gene Amplification in Gastric Cancer Predicts Sensitivity to the Selective FGFR Inhibitor AZD4547

Clinical Cancer Research, 2013
Liang Xie, Xinying Su, Lin Zhang, Xiaolu Yin, Li‐Chuan Tang, Xiuhua Zhang, Yanping Xu, Zeren Gao, Kunji Liu, Minhua Zhou, Beirong Gao, D. Shen, Lianhai Zhang, J. Ji, P. Gavine, Jingchuan Zhang, E. Kilgour, Xiaolin Zhang, Q. Ji   +18 more
semanticscholar   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

EGFR, HER2, and MET gene amplification and protein expression profiles in biliary tract cancer and their prognostic significance. [PDF]

Oncologist
Kim Y, Jee S, Kim H, Paik SS, Choi D, Yoo SH, Shin SJ.   +6 more
europepmc   +1 more source

Primer sequences used to amplify the genes of interest in this study.

Jing Fan (149601), Qiujin Zhang (472724), Liu Zheng (1880860), Binbin Yang (2259313), He Jin (12261804), Tingyu Meng (22560141), Zhixiang Ding (15349443)   +6 more
openalex   +1 more source

KRAS gene amplification in colorectal cancer and impact on response to EGFR‐targeted therapy

International Journal of Cancer, 2013
E. Valtorta, S. Misale, A. Sartore-Bianchi, I. Nagtegaal, F. Paraf, C. Lauricella, V. Dimartino, S. Hobor, B. Jacobs, Cristiana Ercolani, S. Lamba, E. Scala, S. Veronese, P. Laurent-Puig, S. Siena, S. Tejpar, M. Mottolese, C. Punt, M. Gambacorta, A. Bardelli, F. Nicolantonio   +20 more
semanticscholar   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Durable partial response to pembrolizumab, lenvatinib, and letrozole in a case of recurrent uterine carcinosarcoma with ESR1 gene amplification. [PDF]

Gynecol Oncol Rep
Soiffer JL, Fife AJ, Gadad SS, Laurini JA, Elvin JA, Isani SS, Lin KY.   +6 more
europepmc   +1 more source

Intratumoral heterogeneity of HER2 gene amplification in breast cancer: its clinicopathological significance

Modern Pathology, 2012
H. Seol, H. Lee, Yoomi Choi, H. Lee, Y. J. Kim, J. Kim, E. Kang, Sung-Won Kim, S. Y. Park   +8 more
semanticscholar   +1 more source

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source

EMSY Gene Amplification [PDF]

, 2020
openaire   +1 more source