Results 251 to 260 of about 8,013,600 (393)

Frequent and Focal FGFR1 Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer

Science Translational Medicine, 2010
J. Weiss, M. Sos, D. Seidel, M. Peifer, T. Zander, J. Heuckmann, R. Ullrich, R. Menon, Sebastian Maier, A. Soltermann, H. Moch, P. Wagener, Florian Fischer, Stefanie Heynck, Mirjam Koker, Jakob Schöttle, F. Leenders, F. Gabler, I. Dabow, S. Querings, L. Heukamp, H. Balke-Want, S. Ansén, D. Rauh, Ingelore Baessmann, J. Altmüller, Z. Wainer, M. Conron, Gavin Wright, P. Russell, B. Solomon, E. Brambilla, C. Brambilla, P. Lorimier, S. Sollberg, O. Brustugun, W. Engel‐Riedel, C. Ludwig, I. Petersen, J. Sänger, J. Clement, H. Groen, W. Timens, H. Sietsma, E. Thunnissen, E. Smit, D. Heideman, F. Cappuzzo, C. Ligorio, S. Damiani, M. Hallek, R. Beroukhim, W. Pao, B. Klebl, M. Baumann, R. Buettner, K. Ernestus, E. Stoelben, J. Wolf, P. Nürnberg, S. Perner, Roman K. Thomas   +61 more
semanticscholar   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Copper-Induced In Vivo Gene Amplification in Budding Yeast. [PDF]

Biodes Res
Wang J, Song J, Fan C, Duan J, He K, Yuan J.   +5 more
europepmc   +1 more source

MDM2 Gene Amplification and Expression of MDM2 and CDK4 are Rare in Ossifying Fibroma of Craniofacial Bones. [PDF]

Head Neck Pathol, 2022
Bahceci DH, Jordan RCK, Horvai AE.
europepmc   +1 more source

Characterization of DNA rearrangements of N‐myc gene amplification in three neuroblastoma cell lines by pulsed‐field gel electrophoresis [PDF]

, 1989
Hiroshi Kato, Kazuhiko Okamura, Yoshikazu Kurosawa, Teruaki Kishikawa, Keiichiro Hashimoto   +4 more
openalex   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Nucleic Acid Lateral Flow Assay Implemented with Isothermal Gene Amplification of SARS-CoV-2 RNA. [PDF]

Biosensors (Basel)
Kyung K, Lee H, Kim SK, Kim DE.
europepmc   +1 more source

A rare radiotherapy-sensitive primitive neuroectodermal tumor with APC gene amplification in an adult: a case report and literature review. [PDF]

J Int Med Res, 2022
He X, Song S, Yang P, Cao F, Li W, Liang P.   +5 more
europepmc   +1 more source

Molecular amplification and purification of theE. colt recCgene product [PDF]

, 1984
Ian D. Hickson, Karen E. Atkinson, L Hutton, Alan E. Tomkinson, Peter T. Emmerson   +4 more
openalex   +1 more source

CINs of the cytoplasm: dissecting dsRNA signaling in chromosomal instability

Molecular Oncology, EarlyView.
Micronuclei, formed during cell division in chromosomal instability settings, rupture and lead to the accumulation of immunogenic double‐stranded RNA in the cytoplasm, activating MAVS‐dependent interferon signaling and innate antitumor immunity.
Aglaia Skolariki, Rose L. Jady‐Clark, Eileen E. Parkes   +2 more
wiley   +1 more source