Results 271 to 280 of about 8,013,600 (393)

Stimulation of adaptive gene amplification by origin firing under replication fork constraint. [PDF]

Nucleic Acids Res, 2022
Whale AJ, King M, Hull RM, Krueger F, Houseley J.   +4 more
europepmc   +1 more source

Gene amplification: mechanisms and involvement in cancer

Biomolecular Concepts, 2013
A. Matsui, T. Ihara, H. Suda, H. Mikami, K. Semba   +4 more
semanticscholar   +1 more source

CDK5 interacts with MST2 and modulates the Hippo signalling pathway

FEBS Open Bio, Volume 15, Issue 4, Page 647-660, April 2025.
By using a yeast‐two‐hybrid system, immune precipitation and a proteomics approach, we identify a novel interaction between CDK5 and MST2, which modulates the mechano‐sensitive Hippo signalling pathway in a liver tumour cell line. MST2 (STK3) is a major upstream kinase in the Hippo signalling pathway, an evolutionary conserved pathway in regulation of ...
Mehak Passi, Jan B. Stöckl, Thomas Fröhlich, Simone Moser, Angelika M. Vollmar, Stefan Zahler   +5 more
wiley   +1 more source

Evaluation of immune checkpoint inhibitor efficacy for solid tumors with CD274 (PD-L1 gene) amplification identified by comprehensive genomic profiling: retrospective study based on a nationwide database. [PDF]

J Immunother Cancer
Nakayama T, Takahama T, Chiba Y, Shiraishi N, Kawakami H, Yonesaka K, Nakagawa K, Hayashi H.   +7 more
europepmc   +1 more source

Detection of SARS-CoV-2 RNA through tandem isothermal gene amplification without reverse transcription. [PDF]

Anal Chim Acta, 2022
Lee H, Lee H, Hwang SH, Jeong W, Kim DE.
europepmc   +1 more source

HDAC4 regulates apoptosis in Acan‐CreERT2;HDAC4d/d mice with osteoarthritis by downregulating ATF4

FEBS Open Bio, Volume 15, Issue 5, Page 726-737, May 2025.
Using the AcanCreERT2;HDAC4fl/fl genetic mouse model, we further investigated the role of histone deacetylase 4 (HDAC4) in chondrocyte apoptosis. We found that knocking down HDAC4 may be associated with chondrocyte apoptosis by upregulating the activating transcription factor 4 (ATF4)/CAAT/enhancer binding protein homologous (CHOP) signaling pathway ...
Jingrui Huang, Yukun Xu, Yujia Li, Yiming Pang, Xueting Ding, Raorao Zhou, Dan Liang, Xianda Che, Yuanyu Zhang, Chunfang Wang, Wenjin Li, Pengcui Li   +11 more
wiley   +1 more source

Durable partial response to pembrolizumab, lenvatinib, and letrozole in a case of recurrent uterine carcinosarcoma with ESR1 gene amplification. [PDF]

Gynecol Oncol Rep
Soiffer JL, Fife AJ, Gadad SS, Laurini JA, Elvin JA, Isani SS, Lin KY.   +6 more
europepmc   +1 more source

Gene Amplification as a Mechanism of Yeast Adaptation to Nonsense Mutations in Release Factor Genes. [PDF]

Genes (Basel), 2021
Maksiutenko EM, Barbitoff YA, Matveenko AG, Moskalenko SE, Zhouravleva GA.   +4 more
europepmc   +1 more source

Assignment of Genes Encoding Metallothioneins I and II to Chinese Hamster Chromosome 3: Evidence for the Role of Chromosome Rearrangement in Gene Amplification [PDF]

, 1984
Raymond L. Stallings, A. Christine Munk, Jonathan L. Longmire, C.E. Hildebrand, Brian D. Crawford   +4 more
openalex   +1 more source

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

FEBS Open Bio, Volume 15, Issue 5, Page 836-855, May 2025.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy, Arnaud Vigneron, Xavier Rousset, Jérome Guitton, Emmanuel Grolleau, Margaux Raffin, Julie Balandier, Gaëlle Lescuyer, Mathilde Bardou, Florence Geiguer, Sébastien Couraud, Claire Bardel, Jean Viallet, Nazim Benzerdjeb, Léa Payen   +14 more
wiley   +1 more source