Results 281 to 290 of about 8,013,600 (393)

Portable Electrochemical DNA Sensors Based on Gene Amplification Reactions to Screen and Identify Pathogen and SNPs. [PDF]

Sensors (Basel), 2022
Tamiya E.
europepmc   +1 more source

The gene for a novel protein, a member of the protein disulphide isomerase/form I phosphoinositide-specific phospholipase C family, is amplified in hydroxyurea-resistant cells [PDF]

, 1992
Murari Chaudhuri, Patricia N. Tonin, William H. Lewis, P. Srinivasan   +3 more
openalex   +1 more source

A potential tumor suppressor role of PLK2 in glioblastoma

FEBS Open Bio, Volume 15, Issue 5, Page 856-866, May 2025.
PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia, Peirui Wang, Hua Xiao, Qishan Ran, Yan Li, Shengtao Yao   +5 more
wiley   +1 more source

MDM2 amplification in rod-shaped chromosomes provides clues to early stages of circularized gene amplification in liposarcoma. [PDF]

Commun Biol
Sydow S, Piccinelli P, Mitra S, Tsagkozis P, Hesla A, B R De Mattos C, Köster J, Magnusson L, Nilsson J, Ameur A, Wardenaar R, Foijer F, Spierings D, Mertens F.   +13 more
europepmc   +1 more source

FGFR2 Gene Amplification in Gastric Cancer Predicts Sensitivity to the Selective FGFR Inhibitor AZD4547

Clinical Cancer Research, 2013
Liang Xie, Xinying Su, Lin Zhang, Xiaolu Yin, Li‐Chuan Tang, Xiuhua Zhang, Yanping Xu, Zeren Gao, Kunji Liu, Minhua Zhou, Beirong Gao, D. Shen, Lianhai Zhang, J. Ji, P. Gavine, Jingchuan Zhang, E. Kilgour, Xiaolin Zhang, Q. Ji   +18 more
semanticscholar   +1 more source

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

FEBS Open Bio, Volume 15, Issue 5, Page 773-792, May 2025.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law, Yuan Gao, Sravya Kovvali, Pankajavalli Thirugnanasambantham, Vicki H. Wysocki, Brian M. M. Ahmer, Venkat Gopalan   +6 more
wiley   +1 more source

B-cell ALL with SOX11 gene amplification associates with a worse outcome. [PDF]

Cell Cycle
Angelakakis G, Varkhedi M, Dabkowski TR, Diaz MJ, Yeagley M, Blanck G.   +5 more
europepmc   +1 more source

Genetic diversity of Datisca cannabina-compatible Frankia strains as determined by sequence analysis of the PCR-amplified 16S rRNA gene [PDF]

, 1994
M. S. Mirza, Sohail Hameed, A.D.L. Akkermans   +2 more
openalex   +1 more source

KRAS gene amplification in colorectal cancer and impact on response to EGFR‐targeted therapy

International Journal of Cancer, 2013
E. Valtorta, S. Misale, A. Sartore-Bianchi, I. Nagtegaal, F. Paraf, C. Lauricella, V. Dimartino, S. Hobor, B. Jacobs, Cristiana Ercolani, S. Lamba, E. Scala, S. Veronese, P. Laurent-Puig, S. Siena, S. Tejpar, M. Mottolese, C. Punt, M. Gambacorta, A. Bardelli, F. Nicolantonio   +20 more
semanticscholar   +1 more source

Characterisation of the role played by ELMO1, GPR141 and the intergenic polymorphism rs918980 in Fuchs' dystrophy in the Indian population

FEBS Open Bio, Volume 15, Issue 5, Page 822-835, May 2025.
This study reports the upregulation of ELMO1 and GPR141 in human Fuchs' endothelial corneal dystrophy (FECD) corneal endothelium and ultraviolet A‐induced FECD mice model. A genetic association of an intergenic single nucleotide polymorphism rs918980 present between both genes is observed with FECD in the Indian population.
Susmita Sharma, Samar Kumar Basak, Sujata Das, Debasmita Pankaj Alone   +3 more
wiley   +1 more source