Results 341 to 350 of about 8,013,600 (393)
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Gene Amplification and Insecticide Resistance
Annual Review of Entomology, 1991Recapitulation des travaux portant sur le mecanisme de resistance des insectes face aux substances toxiques, base sur l'amplification des genes de resistance.
Alan L. Devonshire, Linda M. Field
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Induction of Gene Amplification by Arsenic
Science, 1988Arsenic is a well-established carcinogen in humans, but there is little evidence for its carcinogenicity in animals and it is inactive as an initiator or tumor promoter in two-stage models of carcinogenicity in mice. Two arsenic salts (sodium arsenite and sodium arsenate) induced a high frequency of methotrexate-resistant 3T6 cells, which were shown to
Patricia W. Lamb +4 more
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Is Gene Amplification RNA-directed?
Nature New Biology, 1973Gene amplification in oocytes has been thought to involve a “reverse transcriptase” like that found in the RNA tumour viruses. Neither the template RNA nor the hybrid intermediates required by this theory can be detected in amplifying ovaries.
Max L. Birnstiel +2 more
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2001
Double minutes (DMs) and homogeneously stained regions (HSRs) provide good examples of phenomena that were originally regarded as cytological oddities but have turned out to be expressions of a fundamental process, called DNA or gene amplification. They arise almost exclusively in transformed and malignant cells.
Orlando J. Miller, Eeva Therman
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Double minutes (DMs) and homogeneously stained regions (HSRs) provide good examples of phenomena that were originally regarded as cytological oddities but have turned out to be expressions of a fundamental process, called DNA or gene amplification. They arise almost exclusively in transformed and malignant cells.
Orlando J. Miller, Eeva Therman
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2006
Since the approval of trastuzumab for the treatment of HER2-positive breast cancer (1), there has been an active debate as to the reproducibility and validity of the FDA-approved assays that detect HER2 abnormalities in the tumor tissue. In this chapter, various clinical assays are compared focusing on practical issues.
Yong-kuk Song +2 more
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Since the approval of trastuzumab for the treatment of HER2-positive breast cancer (1), there has been an active debate as to the reproducibility and validity of the FDA-approved assays that detect HER2 abnormalities in the tumor tissue. In this chapter, various clinical assays are compared focusing on practical issues.
Yong-kuk Song +2 more
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Gene Amplification in Rhizobium
1993Rhizobium species have stimulated the scientific interest due to their ability to interact with plants establishing nitrogen-fixing symbioses. During the symbiotic process, an intimate exchange of chemical signals between the partners results in the expression of specific sets of genes from both bacteria and plant cells.
Ma. Lourdes Girard +6 more
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Gene Amplification and qRT-PCR
2014This chapter includes methods for the use of the polymerase chain reaction (PCR) with Pseudomonas, and several specific tips for their successful application in this organism. The first part of the chapter includes methods for purifying genomic DNA from, and amplifying genes from, Pseudomonas, in addition to methods which describe how to prepare a cell
Alain Filloux, Cerith Jones
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Esterase gene amplification in Culex pipiens
Insect Molecular Biology, 1997In the mosquito Culex pipiens one of the major resistance mechanisms to organophosphorous pesticides (OPs) is increased detoxification of insecticide. This resistance is the consequence of overproduction of two types of esterases, esterases A and B, coded at two loci, Est-3 (A esterase) and Est-2 (B esterase).
Guillemaud, Thomas +4 more
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Gene amplification and tumor progression
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1993Proto-oncogenes are the genes which are most frequently found amplified in human tumor cells. Acquisition of a drug-resistant phenotype by gene amplification is frequent for in-vitro cultured cells but is very rare in human tumors. Proto-oncogenes amplified in human tumors belong essentially to one of three families (erbB, ras, myc) or to the 11q13 ...
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Gene amplification and gene correction in somatic cells
Cell, 1982We used gene transfer to identify frequent genetic rearrangements responsible for activating mutant genes in mammalian cells. We transformed an aprt- tk- cell with a plasmid containing a wild-type aprt gene and a truncated, promoterless tk gene. Transformants that integrate a single copy of this plasmid exhibit the aprt+ phenotype but remain tk-.
Richard Axel, James M. Roberts
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