Results 141 to 150 of about 8,793,913 (366)

A CLUSTER OF GENES CONTROLLING THREE ENZYMES IN HISTIDINE BIOSYNTHESIS IN SACCHAROMYCES CEREVISIAE

, 1966
Gerald R. Fink
openalex   +2 more sources

Molecular organization of the cytokine gene cluster, involving the human IL-3, IL-4, IL-5, and GM-CSF genes, on human chromosome 5 [PDF]

, 1989
BH van Leeuwen, ME Martinson, GC Webb, IG Young   +3 more
openalex   +1 more source

A differentially regulated AP2/ERF transcription factor gene cluster acts downstream of a MAP kinase cascade to modulate terpenoid indole alkaloid biosynthesis in Catharanthus roseus

New Phytologist, 2017
P. Paul, S. K. Singh, Barunava Patra, X. Sui, Sitakanta Pattanaik, Ling Yuan   +5 more
semanticscholar   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Clonal rearrangement and expression of the T cell receptor beta gene and involvement of the breakpoint cluster region in blast crisis of CGL [PDF]

, 1986
Luen Chow Chan, Andrew J. Furley, AM Ford, DA Yardumian, MF Greaves   +4 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

The product of the his4 gene cluster in Saccharomyces cerevisiae. A trifunctional polypeptide.

, 1979
Joseph Keesey, Ramunas Bigelis, Gerald R. Fink   +2 more
openalex   +1 more source

VRprofile: gene‐cluster‐detection‐based profiling of virulence and antibiotic resistance traits encoded within genome sequences of pathogenic bacteria

Briefings Bioinform., 2017
Jun Li, Cui Tai, Z. Deng, Weihong Zhong, Y. He, Hong-Yu Ou   +5 more
semanticscholar   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Linker-specific monoclonal antibodies present a simple and reliable detection method for scFv-based CARNK cells

Molecular Therapy: Methods & Clinical Development
Chimeric antigen receptor (CAR) T cell therapies have demonstrated significant successes in treating cancer. Currently, there are six approved CAR T cell products available on the market that target different malignancies of the B cell lineage.
Katharina Schindler, Katharina Eva Ruppel, Claudia Müller, Ulrike Koehl, Stephan Fricke, Dominik Schmiedel   +5 more
doaj   +1 more source