Results 201 to 210 of about 9,738,594 (396)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Haplotypes in the APOA1-C3-A4-A5 gene cluster affect plasma lipids in both humans and baboons [PDF]

, 2004
Qian‐Fei Wang
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

CAGEcleaner: reducing genomic redundancy in gene cluster mining. [PDF]

Bioinformatics
De Vrieze L, Biltjes M, Lukashevich S, Tsurumi K, Masschelein J.   +4 more
europepmc   +2 more sources

Cluster analysis and display of genome-wide expression patterns.

Proceedings of the National Academy of Sciences of the United States of America, 1998
M. Eisen, P. Spellman, P. Brown, D. Botstein   +3 more
semanticscholar   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Benchmarking methods for measuring biosynthetic gene cluster similarity and determination of gene cluster families. [PDF]

Bioinformatics
Oyedele AS, Walker AS.
europepmc   +1 more source

RedEx: a method for seamless DNA insertion and deletion in large multimodular polyketide synthase gene clusters [PDF]

, 2020
Chaoyi Song, Ji Luan, Ruijuan Li, Chanjuan Jiang, Yu Hou, Qingwen Cui, Tianqi Cui, Tan Long, Zai-Chao Ma, Ya‐Jie Tang, A. Francis Stewart, Jun Fu, Youming Zhang, Hailong Wang   +13 more
openalex   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source