TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo+11 more
wiley +1 more source
Identification of Novel Gene Cluster Potentially Associated with Insecticide Resistance in <i>Anopheles gambiae</i> s.l. [PDF]
Ki HD+7 more
europepmc +1 more source
Clustering of multiallele DNA markers near the Huntington's disease gene. [PDF]
Marcy E. MacDonald+9 more
openalex +1 more source
Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu+12 more
wiley +1 more source
A Sucrose-Utilisation Gene Cluster Contributes to Colonisation of Horse Chestnut by Pseudomonas syringae pv. aesculi. [PDF]
Dhaouadi S+8 more
europepmc +1 more source
Complete physical map of the rfb gene cluster encoding biosynthetic enzymes for the O antigen of Salmonella typhimurium LT2 [PDF]
Himanshu Brahmbhatt+3 more
openalex +1 more source
The cochaperone BAG3 promotes the stabilization of p53 under heat stress conditions
Under heat stress, BAG3 translocates to the nucleus and forms a complex with Hsp70 and p53, thereby promoting p53 stabilization and enhancing its transcriptional activity. These findings suggest that BAG3 functions as a cochaperone that supports p53‐mediated stress responses in cooperation with Hsp70.
Ngoc Nguyen Thi Minh+2 more
wiley +1 more source
Study and Modification of the Polycyclic Aromatic Hydrocarbon Degradation Gene Cluster in <i>Burkholderia</i> sp. FM-2. [PDF]
Ma J+8 more
europepmc +1 more source
This study presents a novel approach to teaching Python and bioinformatics using team‐based learning and cloud‐hosted notebooks. By integrating interactive coding into biomedical education, the method improves accessibility, student engagement, and confidence—especially for those without a computing background.
Nuno S. Osório, Leonardo D. Garma
wiley +1 more source
A novel rearrangement of the human βlike globin gene cluster [PDF]
Ronald J. Trent+5 more
openalex +1 more source