Results 341 to 350 of about 9,738,594 (396)

Plant Gene Clusters and Opiates

Science, 2012
A variety of poppy that produces high amounts of an alkaloid opiate requires a cluster of genes that encode key biosynthetic enzymes.
DellaPenna, D., O'Connor, S.
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tRNA2Lys gene clusters in Drosophila

Journal of Molecular Biology, 1981
Abstract We have isolated segments of Drosophila melanogaster DNA that contain two clusters of tRNA 2 Lys genes. In one segment, pPW511, there is a cluster of three of these genes surrounded by other tRNA genes. Two other segments, pPW516 and pPW541. share a 3 × 10 3 base-pair region that has a cluster of four tRNA 2 Lys genes. This cluster is
J P, Gergen, J Y, Loewenberg, P C, Wensink   +2 more
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Polyene antibiotic biosynthesis gene clusters

Applied Microbiology and Biotechnology, 2002
Over the past 15 years the biosynthetic gene clusters for numerous bioactive polyketides have been intensively studied and recently this work has been extended to the antifungal polyene macrolides. These compounds consist of large macrolactone rings that have a characteristic series of conjugated double bonds, as well as an exocyclic carboxyl group and
Aparicio, JF, Caffrey, P, Gil, JA, Zotchev, SB   +3 more
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Computation of Median Gene Clusters

Journal of Computational Biology, 2008
Whole genome comparison based on gene order has become a popular approach in comparative genomics. An important task in this field is the detection of gene clusters, i.e., sets of genes that occur co-localized in several genomes. For most applications, it is preferable to extend this definition to allow for small deviations in the gene content of the ...
Böcker, Sebastian, Jahn, Katharina, Mixtacki, Julia, Stoye, Jens   +3 more
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Zinc finger gene clusters and tandem gene duplication

Proceedings of the fifth annual international conference on Computational biology, 2001
Zinc finger genes in mammalian genomes are frequently found to occur in clusters with cluster members appearing in a tandem array on the chromosome. It has been suggested that in situ gene duplication events are primarily responsible for the evolution of such clusters.
Mengxiang, Tang, Michael, Waterman, Shibu, Yooseph   +2 more
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Hox genes, clusters and collinearity

The International Journal of Developmental Biology, 2018
This year marks the 40th anniversary of the discovery by Ed Lewis of the property of collinearity in the bithorax gene complex in Drosophila. This landmark work illustrated the need to understand regulatory mechanisms that coordinate expression of homeotic gene clusters.
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Consensus Clustering in Gene Expression

2015
In data analysis, clustering is the process of finding groups in unlabelled data according to similarities among them in such a way that data items belonging to the same group are more similar between each other than items in different groups. Consensus clustering is a methodology for combining different clustering solutions from the same data set in a
GALDI, PAOLA, NAPOLITANO, FRANCESCO, TAGLIAFERRI, Roberto   +2 more
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Consistency of Sequence-Based Gene Clusters

Journal of Computational Biology, 2010
In comparative genomics, differences or similarities of gene orders are determined to predict functional relations of genes or phylogenetic relations of genomes. For this purpose, various combinatorial models can be used to specify gene clusters--groups of genes that are co-located in a set of genomes.
Wittler, Roland, Maňuch, Ján, Patterson, Murray, Stoye, Jens   +3 more
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Microarray and Gene-Clustering Analysis

2005
Human mast cells are capable of secreting a plethora of inflammatory mediators and cytokines that may play a pivotal role in innate immune and inflammatory responses. Activation of mast cells by antigen and immunoglobulin E (IgE) results in signaling, gene expression, and expression of inflammatory mediators.
Tsung-Hsien, Tsai, Denise M, Milhorn, Shau-Ku, Huang   +2 more
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Antimicrobials: Expressing antibiotic gene clusters

Nature Microbiology, 2017
Bacterial specialized metabolites are bioactive molecules with antibacterial or other activities that are of tremendous clinical use. New work has revealed that transcript elongation is a distinct and widespread point of secondary metabolic gene regulation, which has implications for expanding drug discovery.
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