Results 121 to 130 of about 9,198,934 (404)

Hydrogels and Wound Healing: Current and Future Prospects

Gels
The care and rehabilitation of acute and chronic wounds have a significant social and economic impact on patients and global health. This burden is primarily due to the adverse effects of infections, prolonged recovery, and the associated treatment costs.
Varshan Gounden, Moganavelli Singh
doaj   +1 more source

Adenovirus-mediated gene transfer to liver grafts: An improved method to maximize infectivity [PDF]

, 1998
Background. Adenoviral gene therapy in liver transplantation has many potential applications, but current vector delivery methods to grafts lack efficiency and require high titers. In this study, we attempted to improve gene delivery efficacy using three
Chia, SH, Fung, JJ, Geller, DA, Kibbe, MR, Murase, N, Starzl, TE, Watkins, SC   +6 more
core   +1 more source

Gene delivery to bone [PDF]

Advanced Drug Delivery Reviews, 2012
Gene delivery to bone is useful both as an experimental tool and as a potential therapeutic strategy. Among its advantages over protein delivery are the potential for directed, sustained and regulated expression of authentically processed, nascent proteins.
openaire   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Design of double-walled carbon nanotubes for biomedical applications [PDF]

, 2012
Double-walled carbon nanotubes (DWNTs) prepared by catalytic chemical vapour deposition were functionalized in such a way that they were optimally designed as a nano-vector for the delivery of small interfering RNA (siRNA), which is of great interest for
Coley, Helen M., Costa, Sara, Flahaut, Emmanuel, Heister, Elena, McFadden, Johnjoe, Neves, Vera, Silva, S. Ravi P., Soula, Brigitte, Tîlmaciu, Carmen   +8 more
core   +2 more sources

Advanced physical techniques for gene delivery based on membrane perforation

Drug Delivery, 2018
Gene delivery as a promising and valid tool has been used for treating many serious diseases that conventional drug therapies cannot cure. Due to the advancement of physical technology and nanotechnology, advanced physical gene delivery methods such as ...
Xiaofan Du, Jing Wang, Quan Zhou, Luwei Zhang, Sijia Wang, Zhen-xi Zhang, C. Yao   +6 more
semanticscholar   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Phosphonium polymers for gene delivery [PDF]

, 2016
Phosphonium salt-containing polymers have very recently started to emerge as attractive materials for the engineering non-viral gene delivery systems.
Abdallah, Bansal, Borguet, Boyer, Carvalho, Chen, Cheng, Cheng, Chu, Cotanda, Floch, Francesca Mastrotto, Ghassemi, Giuseppe Mantovani, Guénin, Heath, Hemp, Hemp, Jangu, Jangu, Jones, Kanazawa, Kanazawa, Kanazawa, Kenawy, Kenawy, Kenawy, Loczenski Rose, Loczenski Rose, Lowe, Matyjaszewski, Moad, Nicolas, Ornelas-Megiatto, Pack, Qian, Semsarilar, Siegwart, Sizovs, Smith, Song, Stekar, Stokes, Tennyson, Vanessa Loczenski Rose, Wang, Wang, Xu, Xue, Xue, Ye, Yim, Yin, Yue, Zeng   +54 more
core   +2 more sources

Macrophage‐targeted delivery of siRNA to silence Mecp2 gene expression attenuates pulmonary fibrosis

, 2021
Yong Mou, Guorao Wu, Qi Wang, Ting Pan, Lei Zhang, Yongjian Xu, Weining Xiong, Qing Zhou, Yi Wang   +8 more
openalex   +1 more source