Results 291 to 300 of about 8,692,782 (389)

Biomaterials for gene delivery.

, 2000
Tsutomu Ishihara, Toshihiro Akaike, Atsushi Maruyama   +2 more
openalex   +2 more sources

Strategies to Design and Optimize Artificial Antigen‐Presenting Cells for T Cell Expansion in Cancer Immunotherapy

Advanced Functional Materials, EarlyView.
This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley   +1 more source

Theoretical Models and Simulations of Gene Delivery with Polyurethane: The Importance of Polyurethane as a Vector in Personalized Therapy. [PDF]

Biomedicines
Jeleriu RM, Hajaj RK, Trăilă IA, Zaharie M, Puiu M.   +4 more
europepmc   +1 more source

Flow‐Induced Vascular Remodeling on‐Chip: Implications for Anti‐VEGF Therapy

Advanced Functional Materials, EarlyView.
Flow‐induced vascular remodeling plays a critical role in network stabilization and function. Using a vasculature‐on‐chip system, this study reveals how physiological VEGF levels and flow affect vascular remodeling and provides insights into tumor vessel normalization.
Fatemeh Mirzapour‐Shafiyi, Elias Huber, Leonie Karr, Johnny Tong, Andreas Richard Bausch, Friedrich Christian Simmel, Karen Alim   +6 more
wiley   +1 more source

Hypoxia and HIF-1 inhibition enhance lentiviral transduction efficiency: a novel strategy for gene delivery optimization. [PDF]

BMC Biotechnol
Huo Q, Wang W, Dai J, Yuan X, Yu D, Xu B, Chi Y, Li H, Pei XL, Zhu G, Zhang L.   +10 more
europepmc   +1 more source

Bacteria‐Derived Extracellular Vesicle as A “Trojan Horse” for Selective M1 Macrophage‐Targeting in A Multi‐Cellular Entanglement Environment

Advanced Functional Materials, EarlyView.
The temporary transition of macrophages from a pro‐inflammatory phenotype of macrophages (M1) to an anti‐inflammatory phenotype of macrophages (M2) is crucial for tissue repair and regeneration processes. Bacterial outer membrane vesicles (OMVs) are utilized as a “trojan horse” for specific M1 macrophage‐targeting and anti‐inflammatory drug delivery ...
Donglin Cai, Zhelun Li, Wendong Gao, Yuqing Mu, Jiaying Liu, Yufeng Zhang, Xiaohan Mei, Jingjing Quan, Lan Xiao, Yin Xiao   +9 more
wiley   +1 more source

Human tissue kallikrein gene delivery attenuates hypertension, renal injury, and cardiac remodeling in chronic renal failure

, 2000
William C. De Wolf, Hideaki Yoshida, Jun Agata, Lee Chao, Julie Chao   +4 more
openalex   +1 more source

Biomimetic Nanomedicines Deliver Naringin for Enhanced Acute Liver Failure Therapy via Balanced Regulation of Hepatocyte Oxidative Stress and Kupffer Cell Inflammation

Advanced Functional Materials, EarlyView.
A biomimetic nanomedicine (RBLN) constructed by loading natural antioxidants to clinically used layered double hydroxide nanoparticles is surface coated with fresh or senescent red blood cell membrane for balanced drug delivery to hepatocytes and KCs, thereby simultaneously alleviating liver oxidant stress and inflammation for effective drug‐induced ...
Jiahui Shao, Maoze Wang, Jinling Huang, Yu Wang, Jing Zhao, Ran Wang, Zhi Ping Xu, Jianping Jiang, Lingxiao Zhang   +8 more
wiley   +1 more source

Engineered Stem Cell Clusters for Extracellular Vesicles-Mediated Gene Delivery to Rejuvenate Chondrocytes and Facilitate Chondrogenesis in Osteoarthritis Therapy. [PDF]

Adv Sci (Weinh)
Wu Y, Feng Y, Hu F, Zheng X, Ding Y, Liu X, Huo S, Lyu Z.   +7 more
europepmc   +1 more source

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

Advanced Functional Materials, EarlyView.
This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer, Min Jiang, Adrian Kromer, Anny Nguyen, Müge Molbay, Simone Pinto Carneiro, David Jürgens, Gerald Burgstaller, Bastian Popper, Benjamin Winkeljann, Olivia Monika Merkel   +10 more
wiley   +1 more source