Results 301 to 310 of about 8,692,782 (389)

A brief guide for gene delivery to the brain using adeno-associated viral vectors. [PDF]

Mol Cells
Han S, Yang EM, Hur EM.
europepmc   +1 more source

Double Cross‐Linked Hydrogel for Intra‐articular Injection as Modality for Macrophages Metabolic Reprogramming and Therapy of Rheumatoid Arthritis

Advanced Functional Materials, EarlyView.
A hydrogel for intra‐articular injection for the treatment of rheumatoid arthritis (RA) is formulated and comprehensively studied. After administration, the hydrogel induces a metabolic reprogramming of immunometabolism of macrophages to trigger fatty acid oxidation subsequently inducing polarization of anti‐inflammatory M2 macrophages. This results in
Yutong Song, Valentin A. Milichko, Ziqiao Ding, Wen Li, Bei Kang, Yunsheng Dou, Sona Krizkova, Zbynek Heger, Nan Li   +8 more
wiley   +1 more source

High Aspect Ratio Polymer Nanocarriers for Gene Delivery and Expression in Plants. [PDF]

Nano Lett
Zhang Y, Shin J, Sun H, Chang HF, Martinez MR, Perkins LA, Yan J, Cao Y, Wang H, Giraldo JP, Matyjaszewski K, Sheen J, Tilton RD, Marelli B, Lowry GV.   +14 more
europepmc   +1 more source

Magnetically Guided Mechanoactive Mineralization Scaffolds for Enhanced Bone Regeneration

Advanced Functional Materials, EarlyView.
A 3D‐printed ‘rebar‐concrete’ inspired scaffold (PGS‐P@MGel) synergizes spontaneous biomineralization with magneto‐mechanical stimulation through PDA@Fe3O4‐embedded hydrogel. This dual biointerface activates Piezo1/β‐catenin/YAP mechanotransduction axis, enhancing BMSCs osteogenesis and angiogenesis simultaneously.
Xuran Guo, Zaijin Tao, Zhenzhen Dai, Yinghua Gao, Chengzhen Chu, Cunyi Fan, Shen Liu, Xin Ma, Fangchun Jin, Zhengwei You, Jia Jiang   +10 more
wiley   +1 more source

A Penetrable AAV2 Capsid Variant for Efficient Intravitreal Gene Delivery to the Retina. [PDF]

Invest Ophthalmol Vis Sci
He X, Fu Y, Xu Y, Ma L, Chai P, Shi H, Yao Y, Ge S, Jia R, Wen X, Yang Z, Fan X.   +11 more
europepmc   +1 more source

Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks

Advanced Functional Materials, EarlyView.
This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson, Huy Hoang Nguyen, Keng‐Jung Lee, Nattarat Wongsuwan, Ayesha Tupe, Mengrou Lu, Mariah Lynn Arral, Anne Behre, Zihan Ling, Kathryn Ann Whitehead, Adam Walter Feinberg, Xi Ren, Si‐Yang Zheng   +12 more
wiley   +1 more source

Polypiperazine-Based Micelles of Mixed Composition for Gene Delivery. [PDF]

Polymers (Basel)
Stancheva R, Haladjova E, Petrova M, Ugrinova I, Dimitrov I, Rangelov S.   +5 more
europepmc   +1 more source

Targeted cytotoxic gene delivery to malignant gliomas via the fibroblast growth factor receptor

, 2000
Nian‐Ling Zhu, Barbara A. Sosnowski, Berislav V. Zloković, Michael Ong, Thomas C. Chen   +4 more
openalex   +1 more source

A Vertically‐Stacked Optoelectronic Sensor for Localized Hemodynamics Monitoring

Advanced Functional Materials, EarlyView.
This work introduces a hemodynamics monitoring sensor that features vertically stacked microLEDs and a heterogeneously integrated photodetector. The vertically stacked microLEDs enable localized measurements, and by designing the interoptode distance according to the depth of the target region, this vertically stacked optoelectronic sensor is ...
Taeyeon Lee, Jieun Jung, Hyeongoh Park, Dongwuk Jung, Doyune Kim, Changeui Hong, Seungbeom Kang, Hyunsoo Kim, Tae Kim, Jongho Lee   +9 more
wiley   +1 more source

AAV-based gene delivery of antimicrobial peptides to combat drug-resistant pathogens. [PDF]

Appl Environ Microbiol
Baindara P, Roy D, Boosani CS, Mandal SM, Green JA.   +4 more
europepmc   +1 more source