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Therapeutic Delivery Using gene-delivery Methods
Therapeutic Delivery, 2011"With the introduction of the sophisticated tools of molecular biology, gene therapy has evolved as a new therapeutic option for different malignancies".
Ylä-Herttuala Seppo, Wirth Thomas
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2023
To address different diseases, gene therapy is considered to be a powerful tool and, so far, it has been applied in various organs and tissues. However, less attention has been paid to gene delivery to skin despite the fact that skin is an easy-to-access tissue compared with others. One of the main restrictions is the skin barriers prevent diffusion of
Yasaman Esmaeili +3 more
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To address different diseases, gene therapy is considered to be a powerful tool and, so far, it has been applied in various organs and tissues. However, less attention has been paid to gene delivery to skin despite the fact that skin is an easy-to-access tissue compared with others. One of the main restrictions is the skin barriers prevent diffusion of
Yasaman Esmaeili +3 more
openaire +1 more source
Lipid-Based DNA Therapeutics: Hallmarks of Non-Viral Gene Delivery.
ACS Nano, 2019Gene therapy is a promising strategy for the treatment of monogenic disorders. Non-viral gene delivery systems including lipid-based DNA therapeutics offer the opportunity to deliver an encoding gene sequence specifically to the target tissue and thus ...
Jonas Buck +4 more
semanticscholar +1 more source
2008
Gene and RNA interference therapies are promising cures for intractable renal failure. However, low delivery efficiency of the therapeutic nucleic acid into the nucleus of the target cell is a significant obstacle in the clinical application of nonviral gene therapy.
Hidetaka, Akita, Hideyoshi, Harashima
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Gene and RNA interference therapies are promising cures for intractable renal failure. However, low delivery efficiency of the therapeutic nucleic acid into the nucleus of the target cell is a significant obstacle in the clinical application of nonviral gene therapy.
Hidetaka, Akita, Hideyoshi, Harashima
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Expert Opinion on Investigational Drugs, 1999
Experimental studies of viral gene delivery generally support the principle that virus-mediated gene transfer is indeed possible. However, the field of gene therapy has not yet been realised as a practicable clinical intervention. The delay in translation of laboratory work to clinical utility largely reflects the inability of gene delivery vectors to ...
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Experimental studies of viral gene delivery generally support the principle that virus-mediated gene transfer is indeed possible. However, the field of gene therapy has not yet been realised as a practicable clinical intervention. The delay in translation of laboratory work to clinical utility largely reflects the inability of gene delivery vectors to ...
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Ultrasound-mediated gene delivery
Expert Opinion on Drug Delivery, 2010The use of ultrasound with microbubbles raises the possibility of an efficient and safe gene delivery.This review summarizes the current state of the art of gene delivery by sonoporation under the following topics. First, the basic ultrasound parameters and the characteristics of microbubble in biological systems are discussed.
Chang S, Yoon, Jeong H, Park
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An update on calcium carbonate nanoparticles as cancer drug/gene delivery system
Expert Opinion on Drug Delivery, 2019Introduction In recent years, the applications of calcium carbonate (CaCO3) nanoparticles (NPs) have gained extensive interest as targeted drug/gene delivery systems to cancerous tissues and cells due to their accessibility, low cost, safety ...
Solmaz Maleki Dizaj +5 more
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Angewandte Chemie, 2019
Gene therapy has immense potential as a therapeutic approach to serious diseases. However, efficient delivery and real-time tracking of gene therapeutic agents have not been solved well for successful gene-based therapeutics.
Yong Cheng +7 more
semanticscholar +1 more source
Gene therapy has immense potential as a therapeutic approach to serious diseases. However, efficient delivery and real-time tracking of gene therapeutic agents have not been solved well for successful gene-based therapeutics.
Yong Cheng +7 more
semanticscholar +1 more source
Nanoparticles for Gene Delivery
Small, 2013AbstractNanocarriers are a new type of nonviral gene carriers, many of which have demonstrated a broad range of pharmacological and biological properties, such as being biodegradable in the body, stimulusâresponsive towards the surrounding environment, and an abiltiy to specifically targeting certain disease sites.
Huayu, Tian, Jie, Chen, Xuesi, Chen
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Peptide-based gene delivery vectors.
Journal of materials chemistry. B, 2019Gene therapy as a strategy for disease treatment requires safe and efficient gene delivery systems that encapsulate nucleic acids and deliver them to effective sites in the cell. Due to the insecurity of viral vectors, non-viral vectors have gained great
Ziyao Kang, Qingbin Meng, Keliang Liu
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