Results 351 to 360 of about 8,692,782 (389)
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Journal of Dermatological Science, 2008
Over the past decade, many approaches to transferring genes into the skin have been investigated. However, most such approaches have been specifically aimed against genodermatosis, and have not produced sufficient results. The goal of such research is to develop a method in which genes are transferred easily, efficiently and stably into keratinocytes ...
Yasufumi Kaneda +2 more
openaire +3 more sources
Over the past decade, many approaches to transferring genes into the skin have been investigated. However, most such approaches have been specifically aimed against genodermatosis, and have not produced sufficient results. The goal of such research is to develop a method in which genes are transferred easily, efficiently and stably into keratinocytes ...
Yasufumi Kaneda +2 more
openaire +3 more sources
Lipid-Based DNA Therapeutics: Hallmarks of Non-Viral Gene Delivery.
ACS Nano, 2019Gene therapy is a promising strategy for the treatment of monogenic disorders. Non-viral gene delivery systems including lipid-based DNA therapeutics offer the opportunity to deliver an encoding gene sequence specifically to the target tissue and thus ...
Jonas Buck +4 more
semanticscholar +1 more source
2008
Gene delivery by retroviruses is an easy and safe tool to stably over express a gene of interest and determine its role in a cell model. The gene of interest is cloned into the multiple cloning site of a retroviral vector that also contains a packaging signal and an antibiotic resistance marker for selection.
Ernesto Canalis +2 more
openaire +3 more sources
Gene delivery by retroviruses is an easy and safe tool to stably over express a gene of interest and determine its role in a cell model. The gene of interest is cloned into the multiple cloning site of a retroviral vector that also contains a packaging signal and an antibiotic resistance marker for selection.
Ernesto Canalis +2 more
openaire +3 more sources
, 2008 Gene and RNA interference therapies are promising cures for intractable renal failure. However, low delivery efficiency of the therapeutic nucleic acid into the nucleus of the target cell is a significant obstacle in the clinical application of nonviral gene therapy.
Hidetaka Akita, Hideyoshi Harashima
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Current Protocols in Human Genetics, 2001
AbstractThe delivery of genes to skeletal muscle by myoblast implantation, DNA injection, or viral transduction has therapeutic applications for human neuromuscular and systemic disorders, many of which are now represented by transgenic or “knockout” mouse models.
Matthew L. Springer +2 more
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AbstractThe delivery of genes to skeletal muscle by myoblast implantation, DNA injection, or viral transduction has therapeutic applications for human neuromuscular and systemic disorders, many of which are now represented by transgenic or “knockout” mouse models.
Matthew L. Springer +2 more
openaire +3 more sources
2008
Adenoviruses have a number advantages as gene delivery vectors, including ability to transduce a wide variety of non-dividing and dividing cells with high efficiency, relative ease of construction, and ability to be purified as high-titer viral stocks. These characteristics make adenoviruses particularly attractive for over-expressing specific genes in
Renny T. Franceschi, Chunxi Ge
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Adenoviruses have a number advantages as gene delivery vectors, including ability to transduce a wide variety of non-dividing and dividing cells with high efficiency, relative ease of construction, and ability to be purified as high-titer viral stocks. These characteristics make adenoviruses particularly attractive for over-expressing specific genes in
Renny T. Franceschi, Chunxi Ge
openaire +3 more sources
An update on calcium carbonate nanoparticles as cancer drug/gene delivery system
Expert Opinion on Drug Delivery, 2019Introduction In recent years, the applications of calcium carbonate (CaCO3) nanoparticles (NPs) have gained extensive interest as targeted drug/gene delivery systems to cancerous tissues and cells due to their accessibility, low cost, safety ...
Solmaz Maleki Dizaj +5 more
semanticscholar +1 more source
Angewandte Chemie, 2019
Gene therapy has immense potential as a therapeutic approach to serious diseases. However, efficient delivery and real-time tracking of gene therapeutic agents have not been solved well for successful gene-based therapeutics.
Yong Cheng +7 more
semanticscholar +1 more source
Gene therapy has immense potential as a therapeutic approach to serious diseases. However, efficient delivery and real-time tracking of gene therapeutic agents have not been solved well for successful gene-based therapeutics.
Yong Cheng +7 more
semanticscholar +1 more source
A DNA-Based Nanocarrier for Efficient Gene Delivery and Combined Cancer Therapy.
Nano letters (Print), 2018The efficient delivery of a therapeutic gene into target tissues has remained a major obstacle in realizing a viable gene-based medicine. Herein, we introduce a facile and universal strategy to construct a DNA nanostructure-based codelivery system ...
Jianbing Liu +7 more
semanticscholar +1 more source
Current Protocols in Human Genetics, 1999
AbstractViral gene transfer to the liver has proven extremely effective in animal models and is currently being evaluated in clinical trials for a variety of metabolic disorders. In rodents, a single tail vein injection of an adenoviral vector can transduce most hepatocytes in vivo.
openaire +3 more sources
AbstractViral gene transfer to the liver has proven extremely effective in animal models and is currently being evaluated in clinical trials for a variety of metabolic disorders. In rodents, a single tail vein injection of an adenoviral vector can transduce most hepatocytes in vivo.
openaire +3 more sources