Results 361 to 370 of about 9,198,934 (404)
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2018
Although viral vectors comprise the majority of gene delivery vectors, their various safety, production, and other practical concerns have left a research gap to be addressed. The non-viral vector space encompasses a growing variety of physical and chemical methods capable of gene delivery into the nuclei of target cells.
Chi Hong, Sum +3 more
openaire +2 more sources
Although viral vectors comprise the majority of gene delivery vectors, their various safety, production, and other practical concerns have left a research gap to be addressed. The non-viral vector space encompasses a growing variety of physical and chemical methods capable of gene delivery into the nuclei of target cells.
Chi Hong, Sum +3 more
openaire +2 more sources
Advanced Drug Delivery Reviews, 2001
Efficient non-viral gene delivery based on cationic polymers as DNA-condensing agents is dependent on a variety of factors, e.g. complex size, complex stability, toxicity, immunogenicity, protection against DNase degradation, and intracellular trafficking and processing of the DNA.
openaire +2 more sources
Efficient non-viral gene delivery based on cationic polymers as DNA-condensing agents is dependent on a variety of factors, e.g. complex size, complex stability, toxicity, immunogenicity, protection against DNase degradation, and intracellular trafficking and processing of the DNA.
openaire +2 more sources
Gene and Oligonucleotide Delivery
Drug Metabolism and Pharmacokinetics, 2022Shigeru, Kawakami, Hidetoshi, Arima
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In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector
Science, 1996L. Naldini +7 more
semanticscholar +1 more source
1999
Gene therapy became a clinical reality when Rosenberg et al. (1) treated two young patients with adenine deaminase (ADA) deficiency with a retroviral vector that had been biotechnologic ally manipulated to encode for human ADA. Since 1990, approx 300 clinical trials, with a total of over 2000 volunteers or patients participating, have been conducted ...
Frank L. Sorgi, Hans Schreier
openaire +1 more source
Gene therapy became a clinical reality when Rosenberg et al. (1) treated two young patients with adenine deaminase (ADA) deficiency with a retroviral vector that had been biotechnologic ally manipulated to encode for human ADA. Since 1990, approx 300 clinical trials, with a total of over 2000 volunteers or patients participating, have been conducted ...
Frank L. Sorgi, Hans Schreier
openaire +1 more source
Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies
Ca-A Cancer Journal for Clinicians, 2022Paolo Tarantino +2 more
exaly
Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
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Cancer epigenetics in clinical practice
Ca-A Cancer Journal for Clinicians, 2023Veronica Davalos, Manel Esteller
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