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Gene Delivery to the Corneal Endothelium [PDF]
American Journal of Respiratory and Critical Care Medicine, 2000 Gene transfer to the corneal endothelium has potential for modulating rejection of corneal grafts. It can also serve as a convenient and useful model for gene therapy of other organs. In this article we review the work carried out in our laboratory using both viral and nonviral vectors to obtain gene expression in the cornea.
ORAL, HALUK BARBAROS +14 more
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Peptide-based gene delivery vectors.
Journal of materials chemistry. B, 2019Gene therapy as a strategy for disease treatment requires safe and efficient gene delivery systems that encapsulate nucleic acids and deliver them to effective sites in the cell. Due to the insecurity of viral vectors, non-viral vectors have gained great
Ziyao Kang, Qingbin Meng, Keliang Liu
semanticscholar +1 more source
Expert Opinion on Investigational Drugs, 1999
Experimental studies of viral gene delivery generally support the principle that virus-mediated gene transfer is indeed possible. However, the field of gene therapy has not yet been realised as a practicable clinical intervention. The delay in translation of laboratory work to clinical utility largely reflects the inability of gene delivery vectors to ...
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Experimental studies of viral gene delivery generally support the principle that virus-mediated gene transfer is indeed possible. However, the field of gene therapy has not yet been realised as a practicable clinical intervention. The delay in translation of laboratory work to clinical utility largely reflects the inability of gene delivery vectors to ...
openaire +2 more sources
2014
In the previous chapter, we learned how to engineer genes, but we have not yet discussed what to do with them. In this chapter, we will see many different ways of delivering genes into cells. Gene delivery is in itself a powerful biotechnology, but, as we will see in later chapters, it is also a technology that has been built upon for widespread and ...
openaire +2 more sources
In the previous chapter, we learned how to engineer genes, but we have not yet discussed what to do with them. In this chapter, we will see many different ways of delivering genes into cells. Gene delivery is in itself a powerful biotechnology, but, as we will see in later chapters, it is also a technology that has been built upon for widespread and ...
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Advanced Drug Delivery Reviews, 2001
Efficient non-viral gene delivery based on cationic polymers as DNA-condensing agents is dependent on a variety of factors, e.g. complex size, complex stability, toxicity, immunogenicity, protection against DNase degradation, and intracellular trafficking and processing of the DNA.
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Efficient non-viral gene delivery based on cationic polymers as DNA-condensing agents is dependent on a variety of factors, e.g. complex size, complex stability, toxicity, immunogenicity, protection against DNase degradation, and intracellular trafficking and processing of the DNA.
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Current Protocols in Human Genetics, 1999
AbstractThis unit describes generation of and gene transfer to several commonly used airway models. Isolation and transduction of primary airway epithelial cells are first described. Next, the preparation of polarized airway epithelial monolayers is outlined. Transduction of these polarized cells is also described.
D, Duan, Y, Zhang, J F, Engelhardt
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AbstractThis unit describes generation of and gene transfer to several commonly used airway models. Isolation and transduction of primary airway epithelial cells are first described. Next, the preparation of polarized airway epithelial monolayers is outlined. Transduction of these polarized cells is also described.
D, Duan, Y, Zhang, J F, Engelhardt
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Photoresponsive Drug/Gene Delivery Systems.
Biomacromolecules, 2018Light as an external stimulus can be precisely manipulated in terms of irradiation time, site, wavelength, and density. As such, photoresponsive drug/gene delivery systems have been increasingly pursued and utilized for the spatiotemporal control of drug/
Yang Zhou +4 more
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Expert Opinion on Drug Delivery, 2019
Introduction Despite the great therapeutic potential of gene therapy for treating critical diseases, the clinical application is limited by lack of safe and effective gene delivery vectors. Nonviral gene vectors have attracted tremendous attention due to
Cuiping Jiang +5 more
semanticscholar +1 more source
Introduction Despite the great therapeutic potential of gene therapy for treating critical diseases, the clinical application is limited by lack of safe and effective gene delivery vectors. Nonviral gene vectors have attracted tremendous attention due to
Cuiping Jiang +5 more
semanticscholar +1 more source
Synthesis of Lipopolyhydroxyalkyleneamines for Gene Delivery.
ChemInform, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Guisheng Zhang +4 more
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Polycations for Gene Delivery: Dilemmas and Solutions.
Bioconjugate chemistry, 2018Gene therapy has been a promising strategy for treating numerous gene-associated human diseases by altering specific gene expressions in pathological cells.
Jie Chen +4 more
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