Silk Fibroin as a Functional Biomaterial for Drug and Gene Delivery
Pharmaceutics, 2019 Silk is a natural polymer with unique physicochemical and mechanical properties which makes it a desirable biomaterial for biomedical and pharmaceutical applications.
Mhd Anas Tomeh +2 more
semanticscholar +1 more source
Magnetofection potentiates gene delivery to cultured endothelial cells [PDF]
, 2003 Modification of cellular functions by overexpression of genes is increasingly practised for research of signalling pathways, but restricted by limitations of low efficiency. We investigated whether the novel technique of magnetofection (MF) could enhance
Gloe, Torsten +4 more
core +1 more source
Nonviral Gene Delivery with Cationic Glycopolymers.
Accounts of Chemical Research, 2019 The field of gene therapy, which aims to treat patients by modulating gene expression, has come to fruition and has landed several landmark FDA approvals.
Craig Van Bruggen +4 more
semanticscholar +1 more source
The Synergism of Platinum-Gold Bimetallic Nanoconjugates Enhances 5-Fluorouracil Delivery In Vitro
Pharmaceutics, 2019 Nanoparticle application has significantly impacted the field of medicine. The need to develop novel drugs with higher therapeutic potential has stimulated the development of innovative delivery strategies to mitigate the potent side effects associated ...
Vareessh Maney, Moganavelli Singh
doaj +1 more source
Inhibition of miR-96-5p in the mouse brain increases glutathione levels by altering NOVA1 expression
Communications Biology, 2021 Chisato Kinoshita et al. use a microbubble and ultrasound delivery system to inhibit miR-96-5p in the mouse brain. They demonstrate that miR96-5p regulates glutathione levels through the NOVA1 RNA binding protein, suggesting that this microRNA could be a
Chisato Kinoshita +8 more
doaj +1 more source
Liver-specific knockout of arginase-1 leads to a profound phenotype similar to inducible whole body arginase-1 deficiency [PDF]
, 2016 Arginase-1 (Arg1) converts arginine to urea and ornithine in the distal step of the urea cycle in liver. We previously generated a tamoxifen-inducible Arg1 deficient mouse model (Arg1-Cre) that disrupts Arg1 expression throughout the whole body and leads
Al-Dirbashi, Osama Y. +5 more
core +1 more source
Bimetallic nanoparticles as suitable nanocarriers in cancer therapy
Scientific African, 2023 Cancer is a widespread disease which has been prevalent for decades and for which a cure is yet to be discovered. Current treatments are fraught with severe side effects to patients and with no certainty of remission.
Haseena Makada +2 more
doaj
Molecules, 2020 The fruition, commercialisation and clinical application combining nano-engineering, nanomedicine and material science for utilisation in drug delivery is becoming a reality.
Thashini Moodley, Moganavelli Singh
doaj +1 more source
Adenovirus-mediated gene transfer to liver grafts: An improved method to maximize infectivity [PDF]
, 1998 Background. Adenoviral gene therapy in liver transplantation has many potential applications, but current vector delivery methods to grafts lack efficiency and require high titers. In this study, we attempted to improve gene delivery efficacy using three
Chia, SH +6 more
core +1 more source
Dendritic cells steering antigen and leukocyte traffic in lymph nodes
FEBS Letters, EarlyView.Dendritic cells are key players in the activation of T cells and their commitment to effector function. In this In a Nutshell Review, we will discuss how dendritic cells guide the trafficking of antigen and leukocytes in the lymph node, thus influencing T‐cell activation processes. Dendritic cells (DCs) play a central role in initiating and shaping the
Enrico Dotta +3 more
wiley +1 more source