Results 171 to 180 of about 1,021,897 (307)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Modeling Control of Invasive Fire Ants by Gene Drive. [PDF]

Adv Sci (Weinh)
Liu Y, Champer SE, Haller BC, Champer J.
europepmc   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Gene-drive-capable mosquitoes suppress patient-derived malaria in Tanzania. [PDF]

Nature
Habtewold T, Lwetoijera DW, Hoermann A, Mashauri R, Matwewe F, Mwanga R, Kweyamba P, Maganga G, Magani BP, Mtama R, Mahonje MA, Tambwe MM, Tarimo F, Chennuri PR, Cai JA, Del Corsano G, Capriotti P, Sasse P, Moore J, Hudson D, Manjurano A, Tarimo B, Vlachou D, Moore S, Windbichler N, Christophides GK.   +25 more
europepmc   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

A conjugal gene drive-like system efficiently suppresses antibiotic resistance in a bacterial population. [PDF]

NPJ Antimicrob Resist
Kaduwal S, Stuart EC, Auradkar A, Washabaugh S, Meyer JR, Bier E.   +5 more
europepmc   +1 more source

Transformative Approaches for Sustainable Weed Management: The Power of Gene Drive and CRISPR-Cas9. [PDF]

Genes (Basel), 2023
Kumam Y, Trick HN, Vara Prasad PV, Jugulam M.   +3 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Engineering gene drive docking sites in a haplolethal locus in Anopheles gambiae. [PDF]

Sci Rep
Smidler AL, Marrogi EA, Scott S, Mameli E, Abernathy D, Akbari OS, Church GM, Catteruccia F, Esvelt K.   +8 more
europepmc   +1 more source

Next-generation CRISPR gene-drive systems using Cas12a nuclease. [PDF]

Nat Commun, 2023
Sanz Juste S, Okamoto EM, Nguyen C, Feng X, López Del Amo V.   +4 more
europepmc   +1 more source