Transforming malaria prevention and control: the prospects and challenges of gene drive technology for mosquito management [PDF]
Annals of Medicine, 2023 Background: In the era of insecticides and anti-malarial drug resistance, gene drive technology holds considerable promise for malaria control. Gene drive technology deploys genetic modifications into mosquito populations to impede their ability to ...
Yusuf Amuda Tajudeen +7 more
doaj +5 more sources
A Framework for the Risk Assessment and Management of Gene Drive Technology in Contained Use [PDF]
Applied Biosafety, 2018 The utilisation of the CRISPR/Cas9 technology has sparked a renewed interest in gene drive mechanisms.
van der Vlugt, Cécile J. B. +4 more
exaly +5 more sources
Conservation demands safe gene drive. [PDF]
PLoS Biology, 2017 Interest in developing gene drive systems to control invasive species is growing, with New Zealand reportedly considering the nascent technology as a way to locally eliminate the mammalian pests that threaten its unique flora and fauna.
Kevin M Esvelt, Neil J Gemmell
doaj +2 more sources
CRISPR/Cas9 Gene Drive: Growing Pains for a New Technology [PDF]
Genetics, 2017 In this commentary, Floyd Reed discusses [Unckless et al. (2017)][1], “[Evolution of resistance against CRISPR/Cas9 gene drive][2],” which was published in the February issue of GENETICS.
Floyd Reed
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Gene drives as a new quality in GMO releases—a comparative technology characterization [PDF]
PeerJ, 2019 Compared to previous releases of genetically modified organisms (GMOs) which were primarily plants, gene drives represent a paradigm shift in the handling of GMOs: Current regulation of the release of GMOs assumes that for specific periods of time a ...
Johannes L. Frieß +2 more
doaj +4 more sources
Environmental Science and Policy, 2021 Abstract Co-production is an increasingly popular framework for knowledge generation, evaluation and decision making. Despite its potential to open up decisions and practices to the input of others, co-production regularly falls short of its transformative ambitions.
Sarah Hartley, Katie Ledingham
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A Culturally Grounded Method for Dialogue Between Indigenous Peoples and Researchers on Emerging Technologies: Lessons from the Gene Drive Context [version 1; peer review: awaiting peer review] [PDF]
Gates Open ResearchThis paper presents a participatory method for conducing a collaborative and culturally appropriate dialogue process between gene drive researchers and Indigenous Peoples and local communities.
Carolina Torres +17 more
doaj +2 more sources
Governing Gene Drive Technologies: A Qualitative Interview Study [PDF]
AJOB Empirical Bioethics, 2021 Gene drive technologies (GDTs) bias the inheritance of a genetic element within a population of non-human organisms, promoting its progressive spread across this population. If successful, GDTs may be used to counter intractable problems such as vector-borne diseases. A key issue in the debate on GDTs relates to what governance is appropriate for these
N. de Graeff +3 more
openaire +3 more sources
Experts’ moral views on gene drive technologies: a qualitative interview study [PDF]
BMC Medical Ethics, 2021 Abstract Background Gene drive technologies (GDTs) promote the rapid spread of a particular genetic element within a population of non-human organisms. Potential applications of GDTs include the control of insect vectors, invasive species and agricultural pests.
N. de Graeff +2 more
openaire +3 more sources