Results 31 to 40 of about 11,418,435 (287)

Driven to extinction? The ethics of eradicating mosquitoes with gene-drive technologies [PDF]

Journal of Medical Ethics, 2016
Mosquito-borne diseases represent a significant global disease burden, and recent outbreaks of such diseases have led to calls to reduce mosquito populations. Furthermore, advances in 'gene-drive' technology have raised the prospect of eradicating certain species of mosquito via genetic modification.
openaire   +3 more sources

The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito. [PDF]

PLoS Genetics, 2017
Gene drives have enormous potential for the control of insect populations of medical and agricultural relevance. By preferentially biasing their own inheritance, gene drives can rapidly introduce genetic traits even if these confer a negative fitness ...
Andrew M Hammond, Kyros Kyrou, Marco Bruttini, Ace North, Roberto Galizi, Xenia Karlsson, Nace Kranjc, Francesco M Carpi, Romina D'Aurizio, Andrea Crisanti, Tony Nolan   +10 more
doaj   +1 more source

Providing a policy framework for responsible gene drive research: an analysis of the existing governance landscape and priority areas for further research [version 1; peer review: 2 approved, 1 approved with reservations]

Wellcome Open Research, 2020
The progress in gene drive research has made the possibility of a future release in the environment probable. This prospect is raising new questions related to the adequacy of the policy frameworks in place to manage and regulate the research and its ...
Delphine Thizy, Isabelle Coche, Jantina de Vries   +2 more
doaj   +1 more source

MGDrivE 2: A simulation framework for gene drive systems incorporating seasonality and epidemiological dynamics.

PLoS Computational Biology, 2021
Interest in gene drive technology has continued to grow as promising new drive systems have been developed in the lab and discussions are moving towards implementing field trials.
Sean L Wu, Jared B Bennett, Héctor M Sánchez C, Andrew J Dolgert, Tomás M León, John M Marshall   +5 more
doaj   +1 more source

Nuclease-based gene drives, an innovative tool for insect vector control: advantages and challenges of the technology [PDF]

Current Opinion in Insect Science, 2020
Genetic control of insects involves the release of modified insects that contain altered genetic traits and are competent to mate with target populations to introduce the traits therein. Since it relies on mating, this type of control is species-specific, non-toxic, and has the advantage that the released insects can do the difficult task of reaching ...
Quinn, Charlotte, Nolan, Tony
openaire   +2 more sources

Association of the CCR5 gene with juvenile idiopathic arthritis [PDF]

, 2010
The CC chemokine receptor 5 (CCR5) has been shown to be important in the recruitment of T-helper cells to the synovium, where they accumulate, drive the inflammatory process and the consequent synovitis and joint destruction.
Martin, P., BSPAR Study Group, Barton, A., UKRAG Consortium, Worthington, J., Gardner-Medwin, J. [CAPS and BSPAR Study Groups], Thomson, W., W Thomson, Flynn, E., A Hinks, E Flynn, J Packham, Packham, J., Hinks, A., S Eyre, J Worthington, Eyre, S.; id_orcid, Eyre, S., Barton, A.; id_orcid, P Martin, Childhood Arthritis Prospective Study (CAPS), Martin, P.; id_orcid, A Barton   +22 more
core   +1 more source

Benefits and risks of gene drives for invasive plant management - the case for common tansy

Frontiers in Agronomy, 2023
Invasive plants cause significant environmental and economic damage, but land managers have few control options. Common tansy (Tanacetum vulgare) is prevalent in many US states and is one of the most reported invasive plants in Minnesota.
Lori Croghan, Alan G. Smith, Matthew A. Tancos, Neil O. Anderson, Roger L. Becker   +4 more
doaj   +1 more source

Gene Drive Technologies for the Control of Invasive Species

Integrative Plant Biotechnology
Pests and disease cause a loss in agronomic output every year, making it more difficult to eradicate hunger and poverty. The arrival of invasive animals has been associated with the disappearances of local wildlife and with major losses in agriculture.
Amna Saghir Aasi, Laiba Ashfaq, Aleena Jaffar, Muhammad Moazzam Bin Rasheed, Waqar Ahmad Khan, Rao Sohail Ahmad Khan   +5 more
openaire   +1 more source

Taking stock: Is gene drive research delivering on its principles? [version 1; peer review: 1 approved, 2 approved with reservations]

Gates Open Research
Gene drive technology has been recognized for its potential to provide durable and cost-effective solutions for previously intractable problems in public health, conservation, and agriculture.
Kristy Hackett, Stephanie L. James, Isabelle Coche, Aaron J. Roberts, Michael Santos, Katherine Littler, Claudia I. Emerson   +6 more
doaj   +1 more source

Digital droplet PCR and IDAA for the detection of CRISPR indel edits in the malaria species Anopheles stephensi

BioTechniques, 2020
CRISPR/Cas9 technology is a powerful tool for the design of gene-drive systems to control and/or modify mosquito vector populations; however, CRISPR/Cas9-mediated nonhomologous end joining mutations can have an important impact on generating alleles ...
Rebeca Carballar-Lejarazú, Adam Kelsey, Thai Binh Pham, Eric P Bennett, Anthony A James   +4 more
doaj   +1 more source