Results 51 to 60 of about 11,418,435 (287)
Embracing Dynamic Models for Gene Drive Management [PDF]
, 2021 Robust methods of predicting how gene drive systems will interact with ecosystems is essential for safe deployment of gene drive technology. We describe how quantitative tools can reduce risk uncertainty, streamline empirical research, guide risk ...
Ruell, Emily W. +3 more
core
Journal of Hematology & OncologyCD19 CAR T-cells have shown promise in treating systemic lupus erythematosus (SLE), however, relapses demonstrate persistently elevated autoantibodies characteristic of CD19-negative long-lived plasma cells (LLPCs).
Ming Hong +20 more
doaj +1 more source
A New Approach to Develop Resistant Cultivars Against the Plant Pathogens: CRISPR Drives
Frontiers in Plant Science, 2022 CRISPR drive is a recent and robust tool that allows durable genetic manipulation of the pest population like human disease vectors such as malaria vector mosquitos.
Mumin Ibrahim Tek, Kubra Budak
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
A Y-chromosome shredding gene drive for controlling pest vertebrate populations
eLife, 2019 Self-replicating gene drives that modify sex ratios or infer a fitness cost could be used to control populations of invasive alien species. The targeted deletion of Y sex chromosomes using CRISPR technology offers a new approach for sex bias that could ...
Thomas AA Prowse +4 more
doaj +1 more source
Scientifically framed gene drive communication perceived as credible but riskier
People and Nature, 2021 Humans have caused a catastrophic decline to animal species and look to emerging technologies to stop the decline. Gene drive is a potential tool that may eradicate invasive rodents known for their devastating impact on native animals.
Edith A. MacDonald +3 more
doaj +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
In Our Image: The Ethics of CRISPR Genome Editing
Biomolecular Concepts, 2021 The advent of genome editing technology promises to transform human health, livestock and agriculture, and to eradicate pest species. This transformative power demands urgent scrutiny and resolution of the ethical conflicts attached to the creation and ...
Eissenberg Joel C.
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Research Advances and Challenges of Gene Drive Technology in Mosquito-Borne Disease Control
Shiyan dongwu yu bijiao yixueMosquito-borne diseases (such as malaria, dengue fever, Zika virus disease, and Chikungunya) pose major threats to global public health, while traditional control methods based on chemical pesticides face severe challenges including enhanced drug ...
YUN Jiaqi +5 more
doaj +1 more source